Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366991858> ?p ?o ?g. }
- W4366991858 endingPage "2065" @default.
- W4366991858 startingPage "2065" @default.
- W4366991858 abstract "Forsythia fruit, edible fruit of Forsythia suspensa (Thunb.) Vahl, which has been found to be effective in treating cholestasis. However, its key component for alleviating cholestasis has not been determined. In this study, four representative active ingredients in forsythia fruit were selected. Through network pharmacology and molecular docking technology, we tried to find the key component for its treatment of cholestasis. Furthermore, the model of cholestasis in mice was established to verify the protective effect of the key component on cholestasis. Network pharmacology and molecular docking showed that forsythoside A (FTA) is the key component of forsythia fruit in the treatment of cholestasis. In vivo experiments revealed that FTA treatment could alleviate liver injury, dysfunction, and collagen deposition induced by cholestasis in mice. At the same time, FTA treatment inhibited inflammatory factor release and fibrosis-related factor expression. In addition, FTA treatment also reduced MMP-2, TLR4, MYD88, NF-κB p65, and p-NF-κB p65 protein expression. In conclusion, FTA, a key component of forsythia fruit, alleviated liver damage and fibrosis caused by cholestasis via inhibiting the TLR4/NF-κB pathway, extracellular matrix accumulation, and inflammatory cytokine expression. The research results could provide a scientific reference for the development of forsythia fruit as a drug or functional food to prevent and treat cholestasis." @default.
- W4366991858 created "2023-04-27" @default.
- W4366991858 creator A5013540955 @default.
- W4366991858 creator A5017076715 @default.
- W4366991858 creator A5056452415 @default.
- W4366991858 creator A5087288951 @default.
- W4366991858 date "2023-04-25" @default.
- W4366991858 modified "2023-10-11" @default.
- W4366991858 title "Exploration of the Molecular Basis of Forsythia Fruit in the Prevention and Treatment of Cholestatic Liver Injury through Network Pharmacology and Molecular Docking" @default.
- W4366991858 cites W1524200184 @default.
- W4366991858 cites W1696748345 @default.
- W4366991858 cites W1726014254 @default.
- W4366991858 cites W1988186345 @default.
- W4366991858 cites W1991550122 @default.
- W4366991858 cites W1994095345 @default.
- W4366991858 cites W1996370046 @default.
- W4366991858 cites W2019525662 @default.
- W4366991858 cites W2032799660 @default.
- W4366991858 cites W2033591223 @default.
- W4366991858 cites W2064208521 @default.
- W4366991858 cites W2079853302 @default.
- W4366991858 cites W2095894499 @default.
- W4366991858 cites W2096021562 @default.
- W4366991858 cites W2109761554 @default.
- W4366991858 cites W2110600904 @default.
- W4366991858 cites W2118926961 @default.
- W4366991858 cites W2133465414 @default.
- W4366991858 cites W2134967712 @default.
- W4366991858 cites W2135919238 @default.
- W4366991858 cites W2144109738 @default.
- W4366991858 cites W2147232946 @default.
- W4366991858 cites W2158217645 @default.
- W4366991858 cites W2159675211 @default.
- W4366991858 cites W2167742884 @default.
- W4366991858 cites W2169678694 @default.
- W4366991858 cites W2207611361 @default.
- W4366991858 cites W2324986020 @default.
- W4366991858 cites W2404355916 @default.
- W4366991858 cites W2518389324 @default.
- W4366991858 cites W2580212801 @default.
- W4366991858 cites W2611608548 @default.
- W4366991858 cites W2613397346 @default.
- W4366991858 cites W2728621008 @default.
- W4366991858 cites W2793218589 @default.
- W4366991858 cites W2884052083 @default.
- W4366991858 cites W2890324251 @default.
- W4366991858 cites W2898515588 @default.
- W4366991858 cites W2903613367 @default.
- W4366991858 cites W2946412700 @default.
- W4366991858 cites W2968582851 @default.
- W4366991858 cites W2972938582 @default.
- W4366991858 cites W2981194593 @default.
- W4366991858 cites W2983597283 @default.
- W4366991858 cites W2988234451 @default.
- W4366991858 cites W3002093296 @default.
- W4366991858 cites W3002911363 @default.
- W4366991858 cites W3049114182 @default.
- W4366991858 cites W3095484986 @default.
- W4366991858 cites W3109233868 @default.
- W4366991858 cites W3119734550 @default.
- W4366991858 cites W3127271349 @default.
- W4366991858 cites W3134421188 @default.
- W4366991858 cites W3163638628 @default.
- W4366991858 cites W3171777789 @default.
- W4366991858 cites W3172673257 @default.
- W4366991858 cites W3193339981 @default.
- W4366991858 cites W3212091672 @default.
- W4366991858 cites W4200045218 @default.
- W4366991858 cites W4200585475 @default.
- W4366991858 cites W4206904645 @default.
- W4366991858 cites W4211123266 @default.
- W4366991858 cites W4214541616 @default.
- W4366991858 cites W4281385414 @default.
- W4366991858 cites W4283261474 @default.
- W4366991858 cites W4283452013 @default.
- W4366991858 cites W4293403469 @default.
- W4366991858 cites W4307062328 @default.
- W4366991858 cites W978308701 @default.
- W4366991858 doi "https://doi.org/10.3390/nu15092065" @default.
- W4366991858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37432229" @default.
- W4366991858 hasPublicationYear "2023" @default.
- W4366991858 type Work @default.
- W4366991858 citedByCount "2" @default.
- W4366991858 countsByYear W43669918582023 @default.
- W4366991858 crossrefType "journal-article" @default.
- W4366991858 hasAuthorship W4366991858A5013540955 @default.
- W4366991858 hasAuthorship W4366991858A5017076715 @default.
- W4366991858 hasAuthorship W4366991858A5056452415 @default.
- W4366991858 hasAuthorship W4366991858A5087288951 @default.
- W4366991858 hasBestOaLocation W43669918581 @default.
- W4366991858 hasConcept C126322002 @default.
- W4366991858 hasConcept C142724271 @default.
- W4366991858 hasConcept C185592680 @default.
- W4366991858 hasConcept C188947578 @default.
- W4366991858 hasConcept C204787440 @default.
- W4366991858 hasConcept C2776409889 @default.
- W4366991858 hasConcept C2776637226 @default.
- W4366991858 hasConcept C2778593092 @default.