Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366992063> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4366992063 endingPage "2160" @default.
- W4366992063 startingPage "2155" @default.
- W4366992063 abstract "The therapy of recurrent, previously irradiated, high-grade gliomas is still a major interdisciplinary challenge, and the overall prognosis remains poor. Reirradiation has been established as a major component of the management of relapse, in addition to further debulking surgery and systemic options. Herein, we present a moderately hypofractionated reirradiation concept with simultaneous integrated boost for such recurrent, previously irradiated tumors.From October 2019 to January 2021, 12 patients with recurrent malignant gliomas were re-irradiated. All patients had previously undergone surgery and irradiation with mostly normal fractions at the time of primary therapy. Radiotherapy of relapse was performed in all patients with 33 Gy, with 2.2 Gy single dose with a simultaneously integrated boost of 40.05 Gy with a single dose of 2.67 Gy in 15 fractions. Nine out of the 12 patients underwent debulking surgery before reirradiation, and seven patients received concurrent chemotherapy with temozolomide. The mean follow-up was 15.5 months.The median overall survival after recurrence was 9.3 months. The survival rate after 1 year was 33%. Toxicity during radiotherapy was low. In two patients, small areas of radionecrosis were observed at follow-up magnetic resonance imaging in the target volume; these patients were clinically asymptomatic.Moderate hypofractionation shortens the duration of radiotherapy and thereby improves accessibility for patients with limited mobility and prognosis, and achieves a respectable overall survival rate. Furthermore, the extent of late toxicity is also acceptable in these preirradiated patients." @default.
- W4366992063 created "2023-04-27" @default.
- W4366992063 creator A5003343670 @default.
- W4366992063 creator A5006783014 @default.
- W4366992063 creator A5010436347 @default.
- W4366992063 creator A5057185329 @default.
- W4366992063 creator A5074834134 @default.
- W4366992063 creator A5086704182 @default.
- W4366992063 creator A5091146773 @default.
- W4366992063 date "2023-04-25" @default.
- W4366992063 modified "2023-09-29" @default.
- W4366992063 title "Moderately Hypofractionated Radio(chemo)therapy With Simultaneous Integrated Boost for Recurrent, Previously Irradiated, High-grade Glioma" @default.
- W4366992063 doi "https://doi.org/10.21873/anticanres.16377" @default.
- W4366992063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37097672" @default.
- W4366992063 hasPublicationYear "2023" @default.
- W4366992063 type Work @default.
- W4366992063 citedByCount "0" @default.
- W4366992063 crossrefType "journal-article" @default.
- W4366992063 hasAuthorship W4366992063A5003343670 @default.
- W4366992063 hasAuthorship W4366992063A5006783014 @default.
- W4366992063 hasAuthorship W4366992063A5010436347 @default.
- W4366992063 hasAuthorship W4366992063A5057185329 @default.
- W4366992063 hasAuthorship W4366992063A5074834134 @default.
- W4366992063 hasAuthorship W4366992063A5086704182 @default.
- W4366992063 hasAuthorship W4366992063A5091146773 @default.
- W4366992063 hasConcept C121608353 @default.
- W4366992063 hasConcept C126322002 @default.
- W4366992063 hasConcept C126838900 @default.
- W4366992063 hasConcept C141071460 @default.
- W4366992063 hasConcept C155806632 @default.
- W4366992063 hasConcept C2777389519 @default.
- W4366992063 hasConcept C2777910003 @default.
- W4366992063 hasConcept C2778227246 @default.
- W4366992063 hasConcept C2780427987 @default.
- W4366992063 hasConcept C2781100745 @default.
- W4366992063 hasConcept C29730261 @default.
- W4366992063 hasConcept C502942594 @default.
- W4366992063 hasConcept C509974204 @default.
- W4366992063 hasConcept C71924100 @default.
- W4366992063 hasConceptScore W4366992063C121608353 @default.
- W4366992063 hasConceptScore W4366992063C126322002 @default.
- W4366992063 hasConceptScore W4366992063C126838900 @default.
- W4366992063 hasConceptScore W4366992063C141071460 @default.
- W4366992063 hasConceptScore W4366992063C155806632 @default.
- W4366992063 hasConceptScore W4366992063C2777389519 @default.
- W4366992063 hasConceptScore W4366992063C2777910003 @default.
- W4366992063 hasConceptScore W4366992063C2778227246 @default.
- W4366992063 hasConceptScore W4366992063C2780427987 @default.
- W4366992063 hasConceptScore W4366992063C2781100745 @default.
- W4366992063 hasConceptScore W4366992063C29730261 @default.
- W4366992063 hasConceptScore W4366992063C502942594 @default.
- W4366992063 hasConceptScore W4366992063C509974204 @default.
- W4366992063 hasConceptScore W4366992063C71924100 @default.
- W4366992063 hasIssue "5" @default.
- W4366992063 hasLocation W43669920631 @default.
- W4366992063 hasLocation W43669920632 @default.
- W4366992063 hasOpenAccess W4366992063 @default.
- W4366992063 hasPrimaryLocation W43669920631 @default.
- W4366992063 hasRelatedWork W165245056 @default.
- W4366992063 hasRelatedWork W2002125856 @default.
- W4366992063 hasRelatedWork W2150741177 @default.
- W4366992063 hasRelatedWork W2358125876 @default.
- W4366992063 hasRelatedWork W2360323568 @default.
- W4366992063 hasRelatedWork W3163963294 @default.
- W4366992063 hasRelatedWork W4308785009 @default.
- W4366992063 hasRelatedWork W4322725880 @default.
- W4366992063 hasRelatedWork W4323538044 @default.
- W4366992063 hasRelatedWork W4366992063 @default.
- W4366992063 hasVolume "43" @default.
- W4366992063 isParatext "false" @default.
- W4366992063 isRetracted "false" @default.
- W4366992063 workType "article" @default.