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• W4366992289 startingPage "124576" @default.
• W4366992289 abstract "Reliable diagnostic approaches especially those targeting critical Gram-negative bacteria are urgently needed for the prevention of antimicrobial resistance. Polymyxin B (PMB) which specifically targets the outer membrane of Gram-negative bacteria is the last-line antibiotic against life-threatening multidrug-resistant Gram-negative bacteria. However, increasing number of studies have reported the spread of PMB-resistant strains. With the aim to specifically detect Gram-negative bacteria and potentially reduce the irrational use of antibiotics, we herein rationally designed two Gram-negative bacteria specific fluorescent probes based on our previous activity-toxicity optimization of PMB. The in vitro probe PMS-Dns showed fast and selective labeling of Gram-negative pathogens in complex biological cultures. Subsequently, we constructed the caged in vivo fluorescent probe PMS-Cy-NO2 by conjugating bacterial nitroreductase (NTR)-activatable positive charged hydrophobic near-infrared (NIR) fluorophore with polymyxin scaffold. Significantly, PMS-Cy-NO2 exhibited excellent Gram-negative bacterial detection capability with the differentiation between Gram-positive and Gram-negative in a mouse skin infection model." @default.
• W4366992289 created "2023-04-27" @default.
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• W4366992289 date "2023-08-01" @default.
• W4366992289 modified "2023-10-15" @default.
• W4366992289 title "Polymyxin-based fluorescent probes to combat Gram-negative antimicrobial resistance" @default.
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• W4366992289 doi "https://doi.org/10.1016/j.talanta.2023.124576" @default.
• W4366992289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37148689" @default.
• W4366992289 hasPublicationYear "2023" @default.
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