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• W4366992298 abstract "Normalization of body weight is a treatment objective for diabetes. Therefore, anti-diabetic drugs that cause weight loss are widely used in clinics, with the aim of reducing the risk of chronic complications. However, the effect of weight loss on cognition in patients with diabetes is unclear.Embase, the Cochrane Library, PubMed, and the Web of Science were searched systematically, without study type restrictions, from inception to December 18, 2022. Weight loss was defined as a statistically significant decrease in body mass index (BMI) following an observation or intervention. We conducted an analysis of pooled data using a random-effects model.A total of 619 participants in five studies were included. Weight loss was not associated with cognitive changes in patients with diabetes (standardized mean difference 0.50, 95% confidence interval -0.09 to 1.08). Subgroup analyses showed that this was not significantly affected by the duration of intervention or observation, or the size of the reduction in BMI. However, it was challenging to draw definitive conclusions regarding the effects of interventions and baseline BMI, because only one study was included.Weight loss may be neutral to cognitive function in diabetes, but further studies are required to draw more definitive conclusions." @default.
• W4366992298 created "2023-04-27" @default.
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• W4366992298 date "2023-06-01" @default.
• W4366992298 modified "2023-10-16" @default.
• W4366992298 title "Effects of weight loss on cognitive function in patients with diabetes: A systematic review and meta-analysis" @default.
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• W4366992298 doi "https://doi.org/10.1016/j.diabres.2023.110687" @default.
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