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- W4366992299 startingPage "e15700" @default.
- W4366992299 abstract "Osteoarthritis (OA) is a prevalent progressive disease that frequently coexists with obesity. For several decades, OA was thought to be the result of ageing and mechanical stress on cartilage. Researchers' perspective has been greatly transformed when cumulative findings emphasized the role of adipose tissue in the diseases. Nowadays, the metabolic effect of obesity on cartilage tissue has become an integral part of obesity research; hoping to discover a disease-modifying drug for OA. Recently, several adipokines have been reported to be associated with OA. Particularly, metrnl (meteorin-like) and retinol-binding protein 4 (RBP4) have been recognized as emerging adipokines that can mediate OA pathogenesis. Accordingly, in this review, we will summarize the latest findings concerned with the metabolic contribution of obesity in OA pathogenesis, with particular emphasis on dyslipidemia, insulin resistance and adipokines. Additionally, we will discuss the most recent adipokines that have been reported to play a role in this context. Careful consideration of these molecular mechanisms interrelated with obesity and OA will undoubtedly unveil new avenues for OA treatment." @default.
- W4366992299 created "2023-04-27" @default.
- W4366992299 creator A5038757009 @default.
- W4366992299 creator A5049589570 @default.
- W4366992299 creator A5050856287 @default.
- W4366992299 date "2023-05-01" @default.
- W4366992299 modified "2023-09-25" @default.
- W4366992299 title "Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets" @default.
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