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- W4366992451 abstract "In Palestine, Verbascum fruticulosum is one of the most frequently used traditional medicinal plants. The objective of this study was to analyze the contents of the V. fruticulosum extract and evaluate its biological properties. Plant total phenol, flavonoid, and tannin contents were estimated using Folin–Ciocalteu's, aluminum chloride, and vanillin-hydrochloride colorimetric assays, respectively. Reference biomedical assays were performed to evaluate the cytotoxic, antimicrobial, DPPH free radical scavenging, antilipase, α-amylase, and α-glucosidase inhibitory effects of the extracts. The methanol and acetone extracts exhibited the highest antibacterial activity against Pseudomonas aeruginosa with a Minimum Inhibitory Concentration (MIC) value of 1.56 mg/mL for both extracts. The n-hexane extract demonstrated the most potent activity against Epidermophyton floccosum fungi, with a MIC of 3.13 mg/mL. The aqueous extract exhibited excellent antioxidant activity with a Half-maximal Inhibitory Concentration (IC50) of 0.71 ± 0.31 μg/mL. The acetone extract displayed the highest inhibitory activities against lipase and α-amylase, with IC50 values of 129.05 ± 0.48 μg/mL and 9.01 ± 1.76 μg/mL, respectively. The plant methanolic extract presented the highest inhibitory effect against α-glucosidase (IC50 = 75.46 ± 0.66 μg/mL) and the acetone extract exhibited the highest cytotoxic effect (IC50 =3.79 ± 0.01 mg/mL). This study is the first to investigate the phytochemistry and inhibitory activity of V. fruticulosum against lipase, α-amylase, and α-glucosidase. The results indicate that V. fruticulosum extracts exhibit potential biological activities. Further, in vivo trials are necessary to validate these bioactivities." @default.
- W4366992451 created "2023-04-27" @default.
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- W4366992451 date "2023-06-01" @default.
- W4366992451 modified "2023-09-27" @default.
- W4366992451 title "Total phenol, flavonoids, and tannin contents, antimicrobial, antioxidant, vital digestion enzymes inhibitory and cytotoxic activities of Verbascum fruticulosum" @default.
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- W4366992451 doi "https://doi.org/10.1016/j.eujim.2023.102256" @default.
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