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- W4366992528 abstract "Hypertension is a common comorbidity in patients with Type 2 Diabetes Mellitus (T2DM). One of the new anti-diabetic classes is (SGLT2) inhibitor which is still widely tested in clinical trials for indications beyond T2DM. However, the effect of SGLT2 inhibitors on blood pressure in T2DM patients with renal impairment is still not well known. This study wants to find out the effect of SGLT2 inhibitors on blood pressure in patients with T2DM and renal impairment. This study was conducted on 1–7 January 2023. Two independent researchers systematically extracted data from several databases, such as PubMed Central (PMC), Science Direct, and PUBMED by using MeSH terminology of keywords SGLT2 inhibitor and blood pressure. The extracted studies were then analyzed and selected according to our inclusion criteria such as studies in the last 5 years, diabetic patients with renal impairment, cohort studies, and case-control studies. We excluded systematic reviews, meta-analyses, case series, case reports, studies on pregnant women, children, and animals. Research quality was assessed using Newcastle-Ottawa (NOS). From 3 cohort studies (2173 subjects from various countries), all of them showed SGLT2 inhibitors had significantly lowered systolic blood pressure and also improved the blood pressure profile in the population; All studies have proven good quality based on NOS. In conclusion, SGLT2 inhibitors had a blood pressure-lowering effect in T2DM patients with renal impairment. However, further study is needed to confirm these findings." @default.
- W4366992528 created "2023-04-27" @default.
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- W4366992528 date "2023-04-01" @default.
- W4366992528 modified "2023-09-25" @default.
- W4366992528 title "57. Effect of Sodium-Glucose Cotransporter-2 Inhibitor on Blood Pressure in Patient with Type 2 Diabetes Mellitus with Renal Impairment: a Systematic Review" @default.
- W4366992528 doi "https://doi.org/10.1097/01.hjh.0000935608.32755.d1" @default.
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