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• W4366992652 abstract "Atherosclerotic lower extremity peripheral artery disease affects more than 230 million people worldwide, with prevalence increasing over the past decade. 1 Criqui MH Aboyans V Epidemiology of peripheral artery disease. Circ Res. 2015; 116: 1509-1526 Crossref PubMed Scopus (963) Google Scholar Chronic limb threatening ischaemia is a severe form of peripheral artery disease that affects 11% of patients with peripheral artery disease and is associated with significant cardiovascular morbidity and death. 2 Teraa M Conte MS Moll FL Verhaar MC Critical limb ischemia: current trends and future directions. J Am Heart Assoc. 2016; 5e002938 Crossref PubMed Scopus (155) Google Scholar Furthermore, amputation rates of 10–40% during a 6-month follow-up in patients with non-revascularisable chronic limb threatening ischaemia have been reported, highlighting the severity of atherosclerotic burden and need for improved treatment strategies. 2 Teraa M Conte MS Moll FL Verhaar MC Critical limb ischemia: current trends and future directions. J Am Heart Assoc. 2016; 5e002938 Crossref PubMed Scopus (155) Google Scholar In this disease setting, two randomised clinical trials have compared surgical bypass using vein graft with endovascular treatment: the Bypass versus Angioplasty in Severe Ischaemia of the Leg Trial (BASIL) trial 3 Bradbury AW Adam DJ Bell J et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL) trial: an intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy. J Vasc Surg. 2010; 51: 5S-17 Summary Full Text Full Text PDF PubMed Scopus (417) Google Scholar and the Best Surgical Therapy in Patients with Chronic Limb threatening Ischaemia (BEST-CLI) trial. 4 Farber A Menard MT Conte MS et al. Surgery or endovascular therapy for chronic limb-threatening ischemia. N Engl J Med. 2022; 387: 2305-2316 Crossref PubMed Scopus (45) Google Scholar A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation procedure to restore limb perfusion (BASIL-2): an open-label, randomised, multicentre, phase 3 trialIn the BASIL-2 trial, a best endovascular treatment first revascularisation strategy was associated with a better amputation-free survival, which was largely driven by fewer deaths in the best endovascular treatment group. These data suggest that more patients with chronic limb-threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal, revascularisation procedure to restore limb perfusion should be considered for a best endovascular treatment first revascularisation strategy. Full-Text PDF Open Access" @default.
• W4366992652 created "2023-04-27" @default.
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• W4366992652 date "2023-05-01" @default.
• W4366992652 modified "2023-09-29" @default.
• W4366992652 title "Endovascular reperfusion strategy for infra-popliteal chronic limb threatening ischaemia" @default.
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• W4366992652 doi "https://doi.org/10.1016/s0140-6736(23)00632-3" @default.
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