Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366992736> ?p ?o ?g. }
- W4366992736 endingPage "323" @default.
- W4366992736 startingPage "317" @default.
- W4366992736 abstract "Purpose: We investigated whether a clinically used carbonic anhydrase inhibitor (CAIs) can modulate intraocular pressure (IOP) through soluble adenylyl cyclase (sAC) signaling. Methods: IOP was measured 1 h after topical treatment with brinzolamide, a topically applied and clinically used CAIs, using direct cannulation of the anterior chamber in sAC knockout (KO) mice or C57BL/6J mice in the presence or absence of the sAC inhibitor (TDI-10229). Results: Mice treated with the sAC inhibitor TDI-10229 had elevated IOP. CAIs treatment significantly decreased increased intraocular pressure (IOP) in wild-type, sAC KO mice, as well as TDI-10229-treated mice. Conclusions: Inhibiting carbonic anhydrase reduces IOP independently from sAC in mice. Our studies suggest that the signaling cascade by which brinzolamide regulates IOP does not involve sAC." @default.
- W4366992736 created "2023-04-27" @default.
- W4366992736 creator A5012834359 @default.
- W4366992736 creator A5017937304 @default.
- W4366992736 creator A5024790869 @default.
- W4366992736 creator A5028961156 @default.
- W4366992736 creator A5031595067 @default.
- W4366992736 creator A5079648994 @default.
- W4366992736 date "2023-06-01" @default.
- W4366992736 modified "2023-09-26" @default.
- W4366992736 title "Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase" @default.
- W4366992736 cites W171078749 @default.
- W4366992736 cites W176484652 @default.
- W4366992736 cites W1785865236 @default.
- W4366992736 cites W1933463815 @default.
- W4366992736 cites W1968956612 @default.
- W4366992736 cites W1986742807 @default.
- W4366992736 cites W1996761262 @default.
- W4366992736 cites W2006618734 @default.
- W4366992736 cites W2010438530 @default.
- W4366992736 cites W2015876252 @default.
- W4366992736 cites W2021164331 @default.
- W4366992736 cites W2035222385 @default.
- W4366992736 cites W2038523875 @default.
- W4366992736 cites W2059816966 @default.
- W4366992736 cites W2063496837 @default.
- W4366992736 cites W2064304304 @default.
- W4366992736 cites W2067965061 @default.
- W4366992736 cites W2068034718 @default.
- W4366992736 cites W2078683973 @default.
- W4366992736 cites W2083865711 @default.
- W4366992736 cites W2085448595 @default.
- W4366992736 cites W2087233183 @default.
- W4366992736 cites W2090848174 @default.
- W4366992736 cites W2108030954 @default.
- W4366992736 cites W2131216697 @default.
- W4366992736 cites W2144355583 @default.
- W4366992736 cites W2162899067 @default.
- W4366992736 cites W2171679548 @default.
- W4366992736 cites W2174632119 @default.
- W4366992736 cites W2260248099 @default.
- W4366992736 cites W2318042437 @default.
- W4366992736 cites W2411004523 @default.
- W4366992736 cites W2411570094 @default.
- W4366992736 cites W2460512850 @default.
- W4366992736 cites W2471456962 @default.
- W4366992736 cites W2594201108 @default.
- W4366992736 cites W2732180005 @default.
- W4366992736 cites W3163437223 @default.
- W4366992736 cites W3177833247 @default.
- W4366992736 cites W3196727197 @default.
- W4366992736 cites W4293223565 @default.
- W4366992736 cites W4320856717 @default.
- W4366992736 cites W122350447 @default.
- W4366992736 doi "https://doi.org/10.1089/jop.2022.0180" @default.
- W4366992736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37097314" @default.
- W4366992736 hasPublicationYear "2023" @default.
- W4366992736 type Work @default.
- W4366992736 citedByCount "0" @default.
- W4366992736 crossrefType "journal-article" @default.
- W4366992736 hasAuthorship W4366992736A5012834359 @default.
- W4366992736 hasAuthorship W4366992736A5017937304 @default.
- W4366992736 hasAuthorship W4366992736A5024790869 @default.
- W4366992736 hasAuthorship W4366992736A5028961156 @default.
- W4366992736 hasAuthorship W4366992736A5031595067 @default.
- W4366992736 hasAuthorship W4366992736A5079648994 @default.
- W4366992736 hasConcept C118487528 @default.
- W4366992736 hasConcept C126322002 @default.
- W4366992736 hasConcept C134018914 @default.
- W4366992736 hasConcept C170493617 @default.
- W4366992736 hasConcept C181199279 @default.
- W4366992736 hasConcept C182704531 @default.
- W4366992736 hasConcept C185592680 @default.
- W4366992736 hasConcept C2775914622 @default.
- W4366992736 hasConcept C2778076468 @default.
- W4366992736 hasConcept C2779178603 @default.
- W4366992736 hasConcept C2781092963 @default.
- W4366992736 hasConcept C55493867 @default.
- W4366992736 hasConcept C71924100 @default.
- W4366992736 hasConcept C98274493 @default.
- W4366992736 hasConceptScore W4366992736C118487528 @default.
- W4366992736 hasConceptScore W4366992736C126322002 @default.
- W4366992736 hasConceptScore W4366992736C134018914 @default.
- W4366992736 hasConceptScore W4366992736C170493617 @default.
- W4366992736 hasConceptScore W4366992736C181199279 @default.
- W4366992736 hasConceptScore W4366992736C182704531 @default.
- W4366992736 hasConceptScore W4366992736C185592680 @default.
- W4366992736 hasConceptScore W4366992736C2775914622 @default.
- W4366992736 hasConceptScore W4366992736C2778076468 @default.
- W4366992736 hasConceptScore W4366992736C2779178603 @default.
- W4366992736 hasConceptScore W4366992736C2781092963 @default.
- W4366992736 hasConceptScore W4366992736C55493867 @default.
- W4366992736 hasConceptScore W4366992736C71924100 @default.
- W4366992736 hasConceptScore W4366992736C98274493 @default.
- W4366992736 hasIssue "5" @default.
- W4366992736 hasLocation W43669927361 @default.
- W4366992736 hasLocation W43669927362 @default.
- W4366992736 hasOpenAccess W4366992736 @default.