Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366992985> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4366992985 abstract "Background Radiotherapy-related insufficiency fractures (RRIFs) represent a common, burdensome consequence of pelvic radiotherapy. Their underlying mechanisms remain unclear, and data on the effect of osteoporosis are contradictory, with limited studies assessing bone mineral density (BMD) by dual-energy x-ray absorptiometry (DXA). Methods BMD by DXA (Hologic) scan and fracture risk following pelvic RRIF were retrospectively assessed in 39 patients (median age 68 years) at a tertiary cancer centre. Patient characteristics and treatment history are presented narratively; correlations were explored using univariate regression analyses. Results Additional cancer treatments included chemotherapy ( n = 31), surgery ( n = 20) and brachytherapy ( n = 19). Median interval between initiation of radiotherapy and RRIF was 11 (7.5–20.8) and that between RRIF and DXA 3 was (1–6) months. Three patients had normal BMD, 16 had osteopenia and 16 osteoporosis, following World Health Organization classification. Four patients were <40 years at the time of DXA (all Z -scores > –2). Median 10-year risk for hip and major osteoporotic fracture was 3.1% (1.5–5.7) and 11.5% (7.1–13.8), respectively. Only 33.3% of patients had high fracture risk (hip fracture >4% and/or major osteoporotic >20%), and 31% fell above the intervention threshold per National Osteoporosis Guidelines Group (NOGG) guidance (2017). Higher BMD was predicted by lower pelvic radiotherapy dose (only in L3 and L4), concomitant chemotherapy and higher body mass index. Conclusion At the time of RRIF, most patients did not have osteoporosis, some had normal BMD and overall had low fracture risk. Whilst low BMD is a probable risk factor, it is unlikely to be the main mechanism underlying RRIFs, and further studies are required to understand the predictive value of BMD." @default.
- W4366992985 created "2023-04-27" @default.
- W4366992985 creator A5009764502 @default.
- W4366992985 creator A5011187215 @default.
- W4366992985 creator A5048350074 @default.
- W4366992985 creator A5065025694 @default.
- W4366992985 creator A5076139781 @default.
- W4366992985 creator A5088432162 @default.
- W4366992985 date "2023-04-25" @default.
- W4366992985 modified "2023-10-01" @default.
- W4366992985 title "Radiotherapy-related insufficiency fractures and bone mineral density: what is the connection?" @default.
- W4366992985 cites W1966481454 @default.
- W4366992985 cites W1977179883 @default.
- W4366992985 cites W1988063973 @default.
- W4366992985 cites W1990658356 @default.
- W4366992985 cites W1996449375 @default.
- W4366992985 cites W2000962428 @default.
- W4366992985 cites W2006420179 @default.
- W4366992985 cites W2019250571 @default.
- W4366992985 cites W2027763894 @default.
- W4366992985 cites W2049180403 @default.
- W4366992985 cites W2057580437 @default.
- W4366992985 cites W2099198422 @default.
- W4366992985 cites W2105936312 @default.
- W4366992985 cites W2107490395 @default.
- W4366992985 cites W2136015139 @default.
- W4366992985 cites W2151180223 @default.
- W4366992985 cites W2157647768 @default.
- W4366992985 cites W2165631117 @default.
- W4366992985 cites W2441016394 @default.
- W4366992985 cites W2560287982 @default.
- W4366992985 cites W2565551666 @default.
- W4366992985 cites W2573423141 @default.
- W4366992985 cites W2602377655 @default.
- W4366992985 cites W2772653790 @default.
- W4366992985 cites W2908487134 @default.
- W4366992985 cites W2945223850 @default.
- W4366992985 cites W2978133139 @default.
- W4366992985 cites W3009726399 @default.
- W4366992985 cites W3028467437 @default.
- W4366992985 cites W3084072528 @default.
- W4366992985 cites W3092408120 @default.
- W4366992985 cites W3096033686 @default.
- W4366992985 doi "https://doi.org/10.1530/ec-22-0328" @default.
- W4366992985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37097164" @default.
- W4366992985 hasPublicationYear "2023" @default.
- W4366992985 type Work @default.
- W4366992985 citedByCount "0" @default.
- W4366992985 crossrefType "journal-article" @default.
- W4366992985 hasAuthorship W4366992985A5009764502 @default.
- W4366992985 hasAuthorship W4366992985A5011187215 @default.
- W4366992985 hasAuthorship W4366992985A5048350074 @default.
- W4366992985 hasAuthorship W4366992985A5065025694 @default.
- W4366992985 hasAuthorship W4366992985A5076139781 @default.
- W4366992985 hasAuthorship W4366992985A5088432162 @default.
- W4366992985 hasBestOaLocation W43669929851 @default.
- W4366992985 hasConcept C126322002 @default.
- W4366992985 hasConcept C141071460 @default.
- W4366992985 hasConcept C2776541429 @default.
- W4366992985 hasConcept C2776886416 @default.
- W4366992985 hasConcept C2777083390 @default.
- W4366992985 hasConcept C2778885795 @default.
- W4366992985 hasConcept C2779329777 @default.
- W4366992985 hasConcept C2779384505 @default.
- W4366992985 hasConcept C2780221984 @default.
- W4366992985 hasConcept C2781440623 @default.
- W4366992985 hasConcept C509974204 @default.
- W4366992985 hasConcept C71924100 @default.
- W4366992985 hasConceptScore W4366992985C126322002 @default.
- W4366992985 hasConceptScore W4366992985C141071460 @default.
- W4366992985 hasConceptScore W4366992985C2776541429 @default.
- W4366992985 hasConceptScore W4366992985C2776886416 @default.
- W4366992985 hasConceptScore W4366992985C2777083390 @default.
- W4366992985 hasConceptScore W4366992985C2778885795 @default.
- W4366992985 hasConceptScore W4366992985C2779329777 @default.
- W4366992985 hasConceptScore W4366992985C2779384505 @default.
- W4366992985 hasConceptScore W4366992985C2780221984 @default.
- W4366992985 hasConceptScore W4366992985C2781440623 @default.
- W4366992985 hasConceptScore W4366992985C509974204 @default.
- W4366992985 hasConceptScore W4366992985C71924100 @default.
- W4366992985 hasIssue "7" @default.
- W4366992985 hasLocation W43669929851 @default.
- W4366992985 hasLocation W43669929852 @default.
- W4366992985 hasLocation W43669929853 @default.
- W4366992985 hasOpenAccess W4366992985 @default.
- W4366992985 hasPrimaryLocation W43669929851 @default.
- W4366992985 hasRelatedWork W169277 @default.
- W4366992985 hasRelatedWork W2027977119 @default.
- W4366992985 hasRelatedWork W2088808234 @default.
- W4366992985 hasRelatedWork W2186636613 @default.
- W4366992985 hasRelatedWork W2580835075 @default.
- W4366992985 hasRelatedWork W2598355301 @default.
- W4366992985 hasRelatedWork W2894245327 @default.
- W4366992985 hasRelatedWork W2980887675 @default.
- W4366992985 hasRelatedWork W4214568422 @default.
- W4366992985 hasRelatedWork W4281680585 @default.
- W4366992985 hasVolume "12" @default.
- W4366992985 isParatext "false" @default.
- W4366992985 isRetracted "false" @default.
- W4366992985 workType "article" @default.