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- W4366993015 abstract "Immune cell trafficking constitutes a fundamental component of immunological response to tissue injury, but the contribution of intrinsic RNA nucleotide modifications to this response remains elusive. We report that RNA editor ADAR2 exerts a tissue- and stress-specific regulation of endothelial responses to interleukin-6 (IL-6), which tightly controls leukocyte trafficking in IL-6-inflamed and ischemic tissues. Genetic ablation of ADAR2 from vascular endothelial cells diminished myeloid cell rolling and adhesion on vascular walls and reduced immune cell infiltration within ischemic tissues. ADAR2 was required in the endothelium for the expression of the IL-6 receptor subunit, IL-6 signal transducer (IL6ST; gp130), and subsequently, for IL-6 trans-signaling responses. ADAR2-induced adenosine-to-inosine RNA editing suppressed the Drosha-dependent primary microRNA processing, thereby overwriting the default endothelial transcriptional program to safeguard gp130 expression. This work demonstrates a role for ADAR2 epitranscriptional activity as a checkpoint in IL-6 trans-signaling and immune cell trafficking to sites of tissue injury." @default.
- W4366993015 created "2023-04-27" @default.
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- W4366993015 date "2023-05-01" @default.
- W4366993015 modified "2023-10-03" @default.
- W4366993015 title "The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation" @default.
- W4366993015 cites W1487227918 @default.
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- W4366993015 cites W1880833927 @default.
- W4366993015 cites W1880849922 @default.
- W4366993015 cites W1965089560 @default.
- W4366993015 cites W1971308765 @default.
- W4366993015 cites W1980269624 @default.
- W4366993015 cites W1987530472 @default.
- W4366993015 cites W1989910375 @default.
- W4366993015 cites W1990868699 @default.
- W4366993015 cites W1996063915 @default.
- W4366993015 cites W2001416012 @default.
- W4366993015 cites W2006462446 @default.
- W4366993015 cites W2006708761 @default.
- W4366993015 cites W2008476211 @default.
- W4366993015 cites W2008575823 @default.
- W4366993015 cites W2011400811 @default.
- W4366993015 cites W2012800815 @default.
- W4366993015 cites W2014346055 @default.
- W4366993015 cites W2022192230 @default.
- W4366993015 cites W2034869545 @default.
- W4366993015 cites W2036897871 @default.
- W4366993015 cites W2038479043 @default.
- W4366993015 cites W2046641567 @default.
- W4366993015 cites W2047762573 @default.
- W4366993015 cites W2049384154 @default.
- W4366993015 cites W2051013988 @default.
- W4366993015 cites W2052581447 @default.
- W4366993015 cites W2056573404 @default.
- W4366993015 cites W2059439438 @default.
- W4366993015 cites W2059654418 @default.
- W4366993015 cites W2069284462 @default.
- W4366993015 cites W2072304718 @default.
- W4366993015 cites W2073300038 @default.
- W4366993015 cites W2077231697 @default.
- W4366993015 cites W2090513105 @default.
- W4366993015 cites W2091696306 @default.
- W4366993015 cites W2093076255 @default.
- W4366993015 cites W2099675490 @default.
- W4366993015 cites W2123265753 @default.
- W4366993015 cites W2127365846 @default.
- W4366993015 cites W2129209049 @default.
- W4366993015 cites W2134526812 @default.
- W4366993015 cites W2147736027 @default.
- W4366993015 cites W2151718718 @default.
- W4366993015 cites W2156891661 @default.
- W4366993015 cites W2157233685 @default.
- W4366993015 cites W2162143298 @default.
- W4366993015 cites W2165733162 @default.
- W4366993015 cites W2169456326 @default.
- W4366993015 cites W2169968676 @default.
- W4366993015 cites W2170276833 @default.
- W4366993015 cites W2171597027 @default.
- W4366993015 cites W2179438025 @default.