FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366993103> ?p ?o ?g. }

• W4366993103 endingPage "e4954" @default.
• W4366993103 startingPage "e4954" @default.
• W4366993103 abstract "One factor that can contribute to the development of hypertrophic scar contracture is mechanical stress. Mechanical cyclic stretch stimuli enhance the secretion of endothelin-1 (ET-1) from keratinocyte. Cyclical stretching of fibroblasts also increases the expression level of the transient receptor potential ion channel (TRPC3), which is known to couple with the endothelin receptor and induce intracellular Ca2+ signaling via the calcineurin/nuclear factor of activated T cells (NFAT) pathway. The aim of this study was to investigate the relationship between keratinocytes and fibroblasts when they are stretched.The conditioned medium from stretched keratinocyte was added to the fibroblast populated collagen lattice. Then, we analyzed the levels of endothelin receptor in the human hypertrophic scar tissue and stretched fibroblasts. To address the function of TRPC3, we have used an overexpression system with the collagen lattice. Finally, the TRPC3 overexpressing fibroblasts were transplanted to mouse dorsal skin, and the rate of skin wound contraction was assessed.Conditioned medium from stretched keratinocytes increased the rate of contraction of fibroblast populated collagen lattice. In human hypertrophic scar and stretched fibroblasts, endothelin receptor type B was increased. Cyclic stretching of TRPC3 overexpressing fibroblasts activated NFATc4, and stretched human fibroblasts showed more activation of NFATc4 in response to ET-1. The wound treated with TRPC3 overexpressing fibroblasts showed more contraction than control wound.These findings suggest that cyclical stretching of wounds have an effect on both keratinocytes and fibroblasts, where keratinocytes secret more ET-1, and fibroblasts develop more sensitivity to ET-1 by expressing more endothelin receptors and TRPC3." @default.
• W4366993103 created "2023-04-27" @default.
• W4366993103 creator A5005777376 @default.
• W4366993103 creator A5013779617 @default.
• W4366993103 creator A5017609595 @default.
• W4366993103 creator A5043599826 @default.
• W4366993103 creator A5047102381 @default.
• W4366993103 creator A5062721853 @default.
• W4366993103 creator A5075739577 @default.
• W4366993103 date "2023-04-01" @default.
• W4366993103 modified "2023-10-18" @default.
• W4366993103 title "Stretching Promotes Wound Contraction Through Enhanced Expression of Endothelin Receptor B and TRPC3 in Fibroblasts" @default.
• W4366993103 cites W1777009995 @default.
• W4366993103 cites W1894472884 @default.
• W4366993103 cites W1963560035 @default.
• W4366993103 cites W1966085709 @default.
• W4366993103 cites W1966686696 @default.
• W4366993103 cites W1967860295 @default.
• W4366993103 cites W1970801772 @default.
• W4366993103 cites W1972209970 @default.
• W4366993103 cites W1975221601 @default.
• W4366993103 cites W1986081870 @default.
• W4366993103 cites W1992686988 @default.
• W4366993103 cites W1993536160 @default.
• W4366993103 cites W2013072739 @default.
• W4366993103 cites W2018721364 @default.
• W4366993103 cites W2047935705 @default.
• W4366993103 cites W2048935156 @default.
• W4366993103 cites W2051788770 @default.
• W4366993103 cites W2061869453 @default.
• W4366993103 cites W2068592712 @default.
• W4366993103 cites W2073786795 @default.
• W4366993103 cites W2085293124 @default.
• W4366993103 cites W2095604082 @default.
• W4366993103 cites W2100575239 @default.
• W4366993103 cites W2114372528 @default.
• W4366993103 cites W2142605112 @default.
• W4366993103 cites W2153639272 @default.
• W4366993103 cites W2157476080 @default.
• W4366993103 cites W2159193579 @default.
• W4366993103 cites W2170650344 @default.
• W4366993103 cites W2253619901 @default.
• W4366993103 cites W2403907460 @default.
• W4366993103 cites W2415183088 @default.
• W4366993103 cites W2558098634 @default.
• W4366993103 cites W4237747603 @default.
• W4366993103 doi "https://doi.org/10.1097/gox.0000000000004954" @default.
• W4366993103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37113309" @default.
• W4366993103 hasPublicationYear "2023" @default.
• W4366993103 type Work @default.
• W4366993103 citedByCount "2" @default.
• W4366993103 countsByYear W43669931032023 @default.
• W4366993103 crossrefType "journal-article" @default.
• W4366993103 hasAuthorship W4366993103A5005777376 @default.
• W4366993103 hasAuthorship W4366993103A5013779617 @default.
• W4366993103 hasAuthorship W4366993103A5017609595 @default.
• W4366993103 hasAuthorship W4366993103A5043599826 @default.
• W4366993103 hasAuthorship W4366993103A5047102381 @default.
• W4366993103 hasAuthorship W4366993103A5062721853 @default.
• W4366993103 hasAuthorship W4366993103A5075739577 @default.
• W4366993103 hasBestOaLocation W43669931031 @default.
• W4366993103 hasConcept C105702510 @default.
• W4366993103 hasConcept C126322002 @default.
• W4366993103 hasConcept C134018914 @default.
• W4366993103 hasConcept C149601957 @default.
• W4366993103 hasConcept C155164980 @default.
• W4366993103 hasConcept C163415756 @default.
• W4366993103 hasConcept C170488646 @default.
• W4366993103 hasConcept C170493617 @default.
• W4366993103 hasConcept C185592680 @default.
• W4366993103 hasConcept C202751555 @default.
• W4366993103 hasConcept C203014093 @default.
• W4366993103 hasConcept C2777074287 @default.
• W4366993103 hasConcept C2778698245 @default.
• W4366993103 hasConcept C2780269544 @default.
• W4366993103 hasConcept C2780381497 @default.
• W4366993103 hasConcept C2780383360 @default.
• W4366993103 hasConcept C55493867 @default.
• W4366993103 hasConcept C71924100 @default.
• W4366993103 hasConcept C86803240 @default.
• W4366993103 hasConcept C95444343 @default.
• W4366993103 hasConceptScore W4366993103C105702510 @default.
• W4366993103 hasConceptScore W4366993103C126322002 @default.
• W4366993103 hasConceptScore W4366993103C134018914 @default.
• W4366993103 hasConceptScore W4366993103C149601957 @default.
• W4366993103 hasConceptScore W4366993103C155164980 @default.
• W4366993103 hasConceptScore W4366993103C163415756 @default.
• W4366993103 hasConceptScore W4366993103C170488646 @default.
• W4366993103 hasConceptScore W4366993103C170493617 @default.
• W4366993103 hasConceptScore W4366993103C185592680 @default.
• W4366993103 hasConceptScore W4366993103C202751555 @default.
• W4366993103 hasConceptScore W4366993103C203014093 @default.
• W4366993103 hasConceptScore W4366993103C2777074287 @default.
• W4366993103 hasConceptScore W4366993103C2778698245 @default.
• W4366993103 hasConceptScore W4366993103C2780269544 @default.
• W4366993103 hasConceptScore W4366993103C2780381497 @default.
• W4366993103 hasConceptScore W4366993103C2780383360 @default.
• W4366993103 hasConceptScore W4366993103C55493867 @default.

• next