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- W4366995972 abstract "To investigate the clinical characteristics, diagnosis, and treatment of one patient with primary adrenal natural killer/T-cell lymphoma (PANKTCL), and to strengthen the understanding of this rare type of lymphoma.The clinical manifestations, diagnosis and treatment process, and prognosis of the patient admitted in our hospital were retrospectively analyzed.Combined with pathology, imaging, bone marrow examination， etc, the patient was diagnosed with PANKTCL (CA stage, stage II; PINK-E score 3, high-risk group). Six cycles of P-GemOx+VP-16 regimen（gemcitabine 1 g/m2 d1 + oxaliplatin 100 mg/m2 d 1 + etoposide 60 mg/m2 d 2-4 + polyethylene glycol conjugated asparaginase 3 750 IU d 5） was performed, and complete response was assessed in 4 cycles. Maintenance therapy with sintilimab was administered after the completion of chemotherapy. Eight months after the complete response, the patient experienced disease recurrence and underwent a total of four courses of chemotherapy, during which hemophagocytic syndrome occurred. The patient died of disease progression 1 month later.PANKTCL is rare, relapses easily, and has a worse prognosis. The choice of the P-GemOx+VP-16 regimen combined with sintilimab help to improve the survival prognosis of patient with non-upper aerodigestive tract natural killer /T-cell lymphoma.原发性肾上腺NK/T细胞淋巴瘤临床分析.探讨1例原发性肾上腺NK/T细胞淋巴瘤（primary adrenal natural killer/T-cell lymphoma，PANKTCL）患者的临床特点及诊疗方案，加强对该罕见类型淋巴瘤的认识。.回顾性分析本院收治的1例PANKTCL患者的临床表现、诊疗过程及预后。.结合病理学、影像学及骨髓检查等，患者诊断为PANKTCL（CA分期, II期; PINK-E评分3分，高危组）。治疗上行P-GemOx+VP-16（吉西他滨1 g/m2 d 1+奥沙利铂100 mg/m2 d 1+依托泊苷60 mg/m2 d 2-4+培门冬酶3 750 IU d 5）方案6个周期治疗, 4个周期评估达完全缓解。化疗结束后予以信迪利单抗维持治疗。完全缓解后8个月患者出现疾病复发，共行4个疗程化学治疗，期间发生噬血细胞综合征，1个月后患者疾病进展死亡。.PANKTCL罕见，易复发且预后差，P-GemOx+VP-16 联合信迪利单抗方案治疗有助于改善非上呼吸道消化道NK/T细胞淋巴瘤患者的生存预后。." @default.
- W4366995972 created "2023-04-27" @default.
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- W4366995972 date "2023-04-01" @default.
- W4366995972 modified "2023-10-16" @default.
- W4366995972 title "[Clinical Anslysis of Primary Adrenal NK/T-Cell Lymphoma]." @default.
- W4366995972 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2023.02.013" @default.
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