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• W4366996140 abstract "<italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Objective:</i> The purpose of this study was to quantitatively characterize the shape of the sub-retinal pigment epithelium (sub-RPE, i.e., space bounded by RPE and Bruch's membrane) compartment on SD-OCT using fractal dimension (FD) features and evaluate their impact on risk of subfoveal geographic atrophy (sfGA) progression. <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Methods:</i> This was an IRB-approved retrospective study of 137 subjects with dry age-related macular degeneration (AMD) with subfoveal GA. Based on sfGA status at year five, eyes were categorized as “Progressors” and “Non-progressors”. FD analysis allows quantification of the degree of shape complexity and architectural disorder associated with a structure. To characterize the structural irregularities along the sub-RPE surface between the two groups of patients, a total of 15 shape descriptors of FD were extracted from the sub-RPE compartment of baseline OCT scans. The top four features were identified using minimum Redundancy maximum Relevance (mRmR) feature selection method and evaluated with Random Forest (RF) classifier using three-fold cross validation from the training set (N=90). Classifier performance was subsequently validated on the independent test set (N=47). <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Results:</i> Using the top four FD features, a RF classifier yielded an AUC of 0.85 on the independent test set. Mean fractal entropy (p-value=4.8e-05) was identified as the most significant biomarker; higher values of entropy being associated with greater shape disorder and risk for sfGA progression. <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Conclusions:</i> FD assessment holds promise for identifying high-risk eyes for GA progression. <italic xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>Significance:</i> With further validation, FD features could be potentially used for clinical trial enrichment and assessments for therapeutic response in dry AMD patients." @default.
• W4366996140 created "2023-04-27" @default.
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• W4366996140 date "2023-10-01" @default.
• W4366996140 modified "2023-10-13" @default.
• W4366996140 title "Novel Fractal-based Sub-RPE Compartment OCT Radiomics Biomarkers are Associated with Subfoveal Geographic Atrophy in Dry AMD" @default.
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• W4366996140 doi "https://doi.org/10.1109/tbme.2023.3270201" @default.
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