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- W4366996513 abstract "Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased adiposity and improved insulin sensitivity, are important for its broader health benefits; however, the extent and basis of sex differences in CR’s health benefits are unknown. We found that 30% CR in young (3-month-old) male mice decreased fat mass and improved glucose tolerance and insulin sensitivity, whereas these effects were blunted or absent in young females. Females’ resistance to fat loss was associated with decreased lipolysis, energy expenditure and fatty acid oxidation, and increased postprandial lipogenesis, compared to males. The sex differences in glucose homeostasis were not associated with differential glucose uptake but with altered hepatic ceramide content and substrate metabolism: compared to CR males, CR females had lower TCA cycle activity and higher blood ketone concentrations, a marker of hepatic acetyl-CoA content. This suggests that males use hepatic acetyl-CoA for the TCA cycle whereas in females it accumulates, stimulating gluconeogenesis and limiting hypoglycaemia during CR. In aged mice (18-months old), when females are anoestrus, CR decreased fat mass and improved glucose homeostasis similarly in both sexes. Finally, in a cohort of overweight and obese humans, CR-induced fat loss was also sex- and age-dependent: younger females (<45 years) resisted fat loss compared to younger males while in older subjects (>45 years) this sex difference was absent. Collectively, these studies identify age-dependent sex differences in the metabolic effects of CR and highlight adipose tissue, the liver and oestrogen as key determinants of CR’s metabolic benefits. These findings have important implications for understanding the interplay between diet and health, and for maximising the benefits of CR in humans." @default.
- W4366996513 created "2023-04-27" @default.
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- W4366996513 date "2023-04-25" @default.
- W4366996513 modified "2023-10-06" @default.
- W4366996513 title "The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent" @default.
- W4366996513 cites W1502228276 @default.
- W4366996513 cites W1586584121 @default.
- W4366996513 cites W1608774846 @default.
- W4366996513 cites W1635904172 @default.
- W4366996513 cites W1885291780 @default.
- W4366996513 cites W1933788686 @default.
- W4366996513 cites W1970922933 @default.
- W4366996513 cites W1973003238 @default.
- W4366996513 cites W1973246057 @default.
- W4366996513 cites W1980227770 @default.
- W4366996513 cites W1980825418 @default.
- W4366996513 cites W1982706208 @default.
- W4366996513 cites W1984422410 @default.
- W4366996513 cites W1998334471 @default.
- W4366996513 cites W2001854860 @default.
- W4366996513 cites W2005517492 @default.
- W4366996513 cites W2015668953 @default.
- W4366996513 cites W2016017768 @default.
- W4366996513 cites W2026879177 @default.
- W4366996513 cites W2027423883 @default.
- W4366996513 cites W2030068740 @default.
- W4366996513 cites W2033328379 @default.
- W4366996513 cites W2036140394 @default.
- W4366996513 cites W2039962741 @default.
- W4366996513 cites W2041089358 @default.
- W4366996513 cites W2044782198 @default.
- W4366996513 cites W2048747321 @default.
- W4366996513 cites W2063273990 @default.
- W4366996513 cites W2064841390 @default.
- W4366996513 cites W2067395327 @default.
- W4366996513 cites W2070050178 @default.
- W4366996513 cites W2073656642 @default.
- W4366996513 cites W2080155540 @default.
- W4366996513 cites W2082130856 @default.
- W4366996513 cites W2084946461 @default.
- W4366996513 cites W2086410640 @default.
- W4366996513 cites W2087518655 @default.
- W4366996513 cites W2091170123 @default.
- W4366996513 cites W2091359574 @default.
- W4366996513 cites W2095067561 @default.
- W4366996513 cites W2099579841 @default.
- W4366996513 cites W2100012264 @default.
- W4366996513 cites W2100332091 @default.
- W4366996513 cites W2101894113 @default.
- W4366996513 cites W2106882061 @default.
- W4366996513 cites W2107874132 @default.
- W4366996513 cites W2112429003 @default.
- W4366996513 cites W2116024161 @default.
- W4366996513 cites W2123106337 @default.
- W4366996513 cites W2128925208 @default.
- W4366996513 cites W2129345771 @default.
- W4366996513 cites W2130410032 @default.
- W4366996513 cites W2131193972 @default.
- W4366996513 cites W2132499198 @default.
- W4366996513 cites W2133795831 @default.
- W4366996513 cites W2138207763 @default.
- W4366996513 cites W2143004711 @default.
- W4366996513 cites W2149342749 @default.
- W4366996513 cites W2149635457 @default.
- W4366996513 cites W2156048764 @default.
- W4366996513 cites W2158292585 @default.
- W4366996513 cites W2160078193 @default.
- W4366996513 cites W2160234571 @default.
- W4366996513 cites W2168027139 @default.
- W4366996513 cites W2168227960 @default.
- W4366996513 cites W2168526937 @default.
- W4366996513 cites W2168705381 @default.
- W4366996513 cites W2169456326 @default.
- W4366996513 cites W2179438025 @default.
- W4366996513 cites W2210293160 @default.
- W4366996513 cites W2221677062 @default.
- W4366996513 cites W2231426164 @default.
- W4366996513 cites W2257185202 @default.
- W4366996513 cites W2291140334 @default.
- W4366996513 cites W2298723606 @default.