Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366996814> ?p ?o ?g. }
- W4366996814 endingPage "e0277395" @default.
- W4366996814 startingPage "e0277395" @default.
- W4366996814 abstract "Background CD44 and CD133 are stem cell markers in colorectal cancer (CRC). CD44 has distinctive isoforms with different oncological properties like total CD44 (CD44T) and variant CD44 (CD44V) . Clinical significance of such markers remains elusive. Methods Sixty colon cancer were examined for CD44T/CD44V and CD133 at mRNA level in a quantitative PCR, and clarified for their association with clinicopathological factors. Results (1) Both CD44T and CD44V showed higher expression in primary colon tumors than in non-cancerous mucosas (p<0.0001), while CD133 was expressed even in non-cancerous mucosa and rather decreased in the tumors (p = 0.048). (2) CD44V expression was significantly associated with CD44T expression (R = 0.62, p<0.0001), while they were not correlated to CD133 at all in the primary tumors. (3) CD44V/CD44T expressions were significantly higher in right colon cancer than in left colon cancer (p = 0.035/p = 0.012, respectively), while CD133 expression were not (p = 0.20). (4) In primary tumors, unexpectedly, CD44V/CD44T/CD133 mRNA expressions were not correlated with aggressive phenotypes, but CD44V/CD44T rather significantly with less aggressive lymph node metastasis/distant metastasis (p = 0.040/p = 0.039, respectively). Moreover, both CD44V and CD133 expressions were significantly decreased in liver metastasis as compared to primary tumors (p = 0.0005 and p = 0.0006, respectively). Conclusion Our transcript expression analysis of cancer stem cell markers did not conclude that their expression could represent aggressive phenotypes of primary and metastatic tumors, and rather represented less demand on stem cell marker-positive cancer cells." @default.
- W4366996814 created "2023-04-27" @default.
- W4366996814 creator A5003263977 @default.
- W4366996814 creator A5003620734 @default.
- W4366996814 creator A5017282699 @default.
- W4366996814 creator A5018208537 @default.
- W4366996814 creator A5019725854 @default.
- W4366996814 creator A5029636017 @default.
- W4366996814 creator A5033951172 @default.
- W4366996814 creator A5037840856 @default.
- W4366996814 creator A5039666083 @default.
- W4366996814 creator A5044315890 @default.
- W4366996814 creator A5044971971 @default.
- W4366996814 creator A5048209241 @default.
- W4366996814 creator A5050436711 @default.
- W4366996814 creator A5057517062 @default.
- W4366996814 creator A5065968285 @default.
- W4366996814 creator A5070191441 @default.
- W4366996814 creator A5074085392 @default.
- W4366996814 creator A5076494729 @default.
- W4366996814 creator A5076620739 @default.
- W4366996814 creator A5078301182 @default.
- W4366996814 creator A5078925643 @default.
- W4366996814 creator A5081619973 @default.
- W4366996814 creator A5084329002 @default.
- W4366996814 creator A5087844371 @default.
- W4366996814 creator A5090718839 @default.
- W4366996814 date "2023-04-25" @default.
- W4366996814 modified "2023-10-18" @default.
- W4366996814 title "Less demand on stem cell marker-positive cancer cells may characterize metastasis of colon cancer" @default.
- W4366996814 cites W1673996441 @default.
- W4366996814 cites W1969245473 @default.
- W4366996814 cites W1974270860 @default.
- W4366996814 cites W1984645684 @default.
- W4366996814 cites W1989847140 @default.
- W4366996814 cites W1994292200 @default.
- W4366996814 cites W2000245494 @default.
- W4366996814 cites W2011217149 @default.
- W4366996814 cites W2014153470 @default.
- W4366996814 cites W2027737365 @default.
- W4366996814 cites W2029231546 @default.
- W4366996814 cites W2041399911 @default.
- W4366996814 cites W2041491387 @default.
- W4366996814 cites W2043453608 @default.
- W4366996814 cites W2053757573 @default.
- W4366996814 cites W2060551076 @default.
- W4366996814 cites W2061820966 @default.
- W4366996814 cites W2081447858 @default.
- W4366996814 cites W2082784408 @default.
- W4366996814 cites W2083479805 @default.
- W4366996814 cites W2083998563 @default.
- W4366996814 cites W2084343793 @default.
- W4366996814 cites W2107176012 @default.
- W4366996814 cites W2117767331 @default.
- W4366996814 cites W2117997562 @default.
- W4366996814 cites W2124715710 @default.
- W4366996814 cites W2126002765 @default.
- W4366996814 cites W2127330908 @default.
- W4366996814 cites W2129644533 @default.
- W4366996814 cites W2131170195 @default.
- W4366996814 cites W2143160415 @default.
- W4366996814 cites W2155311724 @default.
- W4366996814 cites W2186636893 @default.
- W4366996814 cites W2262414037 @default.
- W4366996814 cites W2415343213 @default.
- W4366996814 cites W2506489222 @default.
- W4366996814 cites W2600453489 @default.
- W4366996814 cites W2783494975 @default.
- W4366996814 cites W2790065991 @default.
- W4366996814 cites W2886372396 @default.
- W4366996814 cites W2888063818 @default.
- W4366996814 cites W2895926103 @default.
- W4366996814 cites W2912443613 @default.
- W4366996814 cites W2935324060 @default.
- W4366996814 cites W2949324159 @default.
- W4366996814 cites W2975032728 @default.
- W4366996814 cites W3002014546 @default.
- W4366996814 cites W3134870264 @default.
- W4366996814 cites W3165068907 @default.
- W4366996814 doi "https://doi.org/10.1371/journal.pone.0277395" @default.
- W4366996814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37098074" @default.
- W4366996814 hasPublicationYear "2023" @default.
- W4366996814 type Work @default.
- W4366996814 citedByCount "0" @default.
- W4366996814 crossrefType "journal-article" @default.
- W4366996814 hasAuthorship W4366996814A5003263977 @default.
- W4366996814 hasAuthorship W4366996814A5003620734 @default.
- W4366996814 hasAuthorship W4366996814A5017282699 @default.
- W4366996814 hasAuthorship W4366996814A5018208537 @default.
- W4366996814 hasAuthorship W4366996814A5019725854 @default.
- W4366996814 hasAuthorship W4366996814A5029636017 @default.
- W4366996814 hasAuthorship W4366996814A5033951172 @default.
- W4366996814 hasAuthorship W4366996814A5037840856 @default.
- W4366996814 hasAuthorship W4366996814A5039666083 @default.
- W4366996814 hasAuthorship W4366996814A5044315890 @default.
- W4366996814 hasAuthorship W4366996814A5044971971 @default.
- W4366996814 hasAuthorship W4366996814A5048209241 @default.
- W4366996814 hasAuthorship W4366996814A5050436711 @default.