Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366997585> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W4366997585 abstract "Abstract Background Antibodies to histone have been associated in the adult literature with systemic lupus erythematosus(SLE) and drug induced lupus(DILE). Little data is available regarding the spectrum of pathology that antibodies to histone encompass in the pediatric population. Prior studies suggest an association with SLE, juvenile idiopathic arthritis(JIA), uveitis and linear scleroderma. Methods Patient charts were reviewed that contained positive anti-histone antibody testing during a consecutive three year period. Patient diagnosis along with the presence of: anti-histone antibody titer, ANA, and the presence of other autoantibodies to SSA, SSB, Sm, RNP, dsDNA and chromatin were obtained. The frequency of SLE, JIA and DILE was further investigated in specific subsets. Results 139 individual charts were reviewed containing 41 different diagnoses. The most common diagnosis was hypermobility arthralgia with 22 patients. The most frequent rheumatologic diagnosis was JIA(nonsystemic) with 19. 13 patients in this study were diagnosed with SLE and 2 with DILE. 18 patients had other autoantibody production, of these, 11 had SLE or DILE. Only one of 62 patients with a weak antihistone antibody titer(1.0-1.5) was diagnosed with SLE. When strong titers are present(> 2.5), the antihistone antibody test was associated with a greater than 50% incidence of an underlying rheumatologic disease and ten times higher incidence of SLE than a weak titer. In regards to the frequency of SLE, there was a statistically significant difference between weak and moderate titers and between weak and strong titers. Conclusion The presence of anti-histone antibody was observed in a variety of diagnoses in the pediatric population. Overall, the presence of anti-histone antibodies appears to have poor diagnostic utility for any specific condition. However, diagnostic utility for SLE does appear to improve with higher titers, when combined with other autoantibody positivity. Strength of titer did not appear to be a factor for JIA, but was the most frequently observed rheumatologic disease in this study." @default.
- W4366997585 created "2023-04-27" @default.
- W4366997585 creator A5032274574 @default.
- W4366997585 creator A5060066036 @default.
- W4366997585 date "2023-04-25" @default.
- W4366997585 modified "2023-10-01" @default.
- W4366997585 title "Antibodies to histone in the pediatric population: a retrospective chart review" @default.
- W4366997585 cites W1891725501 @default.
- W4366997585 cites W1966022081 @default.
- W4366997585 cites W1973679061 @default.
- W4366997585 cites W1984739752 @default.
- W4366997585 cites W1991234669 @default.
- W4366997585 cites W2015438650 @default.
- W4366997585 cites W2089790873 @default.
- W4366997585 cites W2140684657 @default.
- W4366997585 cites W2155594196 @default.
- W4366997585 cites W2395220856 @default.
- W4366997585 cites W2418656523 @default.
- W4366997585 cites W2419597460 @default.
- W4366997585 cites W4365806197 @default.
- W4366997585 doi "https://doi.org/10.1186/s12969-023-00821-y" @default.
- W4366997585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37098546" @default.
- W4366997585 hasPublicationYear "2023" @default.
- W4366997585 type Work @default.
- W4366997585 citedByCount "0" @default.
- W4366997585 crossrefType "journal-article" @default.
- W4366997585 hasAuthorship W4366997585A5032274574 @default.
- W4366997585 hasAuthorship W4366997585A5060066036 @default.
- W4366997585 hasBestOaLocation W43669975851 @default.
- W4366997585 hasConcept C120665830 @default.
- W4366997585 hasConcept C121332964 @default.
- W4366997585 hasConcept C126322002 @default.
- W4366997585 hasConcept C159654299 @default.
- W4366997585 hasConcept C16005928 @default.
- W4366997585 hasConcept C163764329 @default.
- W4366997585 hasConcept C198451711 @default.
- W4366997585 hasConcept C203014093 @default.
- W4366997585 hasConcept C22889606 @default.
- W4366997585 hasConcept C2776912625 @default.
- W4366997585 hasConcept C2777077863 @default.
- W4366997585 hasConcept C2779134260 @default.
- W4366997585 hasConcept C2908647359 @default.
- W4366997585 hasConcept C32611913 @default.
- W4366997585 hasConcept C61511704 @default.
- W4366997585 hasConcept C71924100 @default.
- W4366997585 hasConcept C99454951 @default.
- W4366997585 hasConceptScore W4366997585C120665830 @default.
- W4366997585 hasConceptScore W4366997585C121332964 @default.
- W4366997585 hasConceptScore W4366997585C126322002 @default.
- W4366997585 hasConceptScore W4366997585C159654299 @default.
- W4366997585 hasConceptScore W4366997585C16005928 @default.
- W4366997585 hasConceptScore W4366997585C163764329 @default.
- W4366997585 hasConceptScore W4366997585C198451711 @default.
- W4366997585 hasConceptScore W4366997585C203014093 @default.
- W4366997585 hasConceptScore W4366997585C22889606 @default.
- W4366997585 hasConceptScore W4366997585C2776912625 @default.
- W4366997585 hasConceptScore W4366997585C2777077863 @default.
- W4366997585 hasConceptScore W4366997585C2779134260 @default.
- W4366997585 hasConceptScore W4366997585C2908647359 @default.
- W4366997585 hasConceptScore W4366997585C32611913 @default.
- W4366997585 hasConceptScore W4366997585C61511704 @default.
- W4366997585 hasConceptScore W4366997585C71924100 @default.
- W4366997585 hasConceptScore W4366997585C99454951 @default.
- W4366997585 hasIssue "1" @default.
- W4366997585 hasLocation W43669975851 @default.
- W4366997585 hasLocation W43669975852 @default.
- W4366997585 hasLocation W43669975853 @default.
- W4366997585 hasLocation W43669975854 @default.
- W4366997585 hasOpenAccess W4366997585 @default.
- W4366997585 hasPrimaryLocation W43669975851 @default.
- W4366997585 hasRelatedWork W1970898494 @default.
- W4366997585 hasRelatedWork W1974456976 @default.
- W4366997585 hasRelatedWork W2047056828 @default.
- W4366997585 hasRelatedWork W2101875571 @default.
- W4366997585 hasRelatedWork W2332869960 @default.
- W4366997585 hasRelatedWork W2365431450 @default.
- W4366997585 hasRelatedWork W2381991529 @default.
- W4366997585 hasRelatedWork W2384171498 @default.
- W4366997585 hasRelatedWork W2425255793 @default.
- W4366997585 hasRelatedWork W2547664563 @default.
- W4366997585 hasVolume "21" @default.
- W4366997585 isParatext "false" @default.
- W4366997585 isRetracted "false" @default.
- W4366997585 workType "article" @default.