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- W4366997639 abstract "Review question / Objective: The Fragility of Statistically Significant Findings from Depression Randomized Controlled Trials. Condition being studied: Depression is a mental disorder characterized by a range of symptoms, including loss of memory and sleep, decreased energy, feelings of guilt or low mood, disturbed appetite, poor concentration, and an increased risk of suicide. According to a systematic analysis of the Global Burden of Disease Study 2019, depression is recognized as the leading cause of disease burden for mental disorders, accounting for the largest proportion of disability-adjusted life years (DALYs) at 37.3%. The fragility index (FI), which is the minimum number of changes from events to non-events resulting in loss of statistical significance, has been suggested as a means to aid the interpretation of trial results, as the potential inadequacy about robustness of threshold P-value as a tool for reporting binary outcomes in clinical trials. In this systematic review, we want to calculate the FI of randomized controlled trials (RCTs) in depression." @default.
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- W4366997639 date "2023-04-25" @default.
- W4366997639 modified "2023-09-29" @default.
- W4366997639 title "The Fragility of Statistically Significant Findings from Depression Randomized Controlled Trials" @default.
- W4366997639 doi "https://doi.org/10.37766/inplasy2023.4.0086" @default.
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