FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366997681> ?p ?o ?g. }

• W4366997681 abstract "Abstract Background High drive and high effort during spontaneous breathing can generate potential patient self-inflicted lung injury (P-SILI), due to uncontrolled high transpulmonary and transvascular pressures, with relapse of respiratory failure. P-SILI has been demonstrated in experimental studies, and supported in recent computational models. Different treatment strategies have been proposed according to the phenotypes of elastance of the respiratory system (Ers) for patients with COVID-19. This study aimed to investigate the effect of different ventilatory strategies on the respiratory drive and muscle effort in the clinical practice, and its relationship with the different phenotypes, by obtaining respiratory signals and calculated muscle pressure. Design: Monocenter physiologic study of series cases. Setting: University medical-surgical ICU. Patients: Eleven mechanically ventilated patients COVID-19 pneumoniae at the initiation of spontaneous breathing were studied. Interventions: Three spontaneous ventilation modes were evaluated: Pressure support ventilation (PSV), airway pressure release ventilation (APRV), and CPAP double in each of the patients. Measurements and main results: The study is based on the calculation of muscle pressure (Pmus) through the equation of motion. For this purpose, we have acquired the respiratory signals of airway pressure (Paw), Flow (V´) and Volume (V) directly from the data transmission protocol of the ventilator (Dräger). The main physiological measurements have been calculation of the respiratory drive (P0.1), muscle effort through the ΔPmus, pressure-time product (PTP_pmus) and power of breathing considered as work of the patient J/min (WOBp). Our results show similar high drive and muscle effort in each of the spontaneous ventilatory modes tested, without significant differences between them. Median (IQR): P0.1 6.12 (4.43-7.21) cmH 2 O, ∆Pmus 13.48 (11.09-17.81) cmH 2 O, PTP 166,29 (124.02-253.33) cmH 2 O*sec/min; and WOBp 11.12 (5.91-17.51) J/min. High Drive and effort are found in patients even with low Ers. The relationship between respiratory drive and “power of breathing” versus Ers, although with a wide coefficient of variation, is significant. We have found a trend towards a worse prognosis in terms of survival and stay in the ICU, in patients with high drive and inspiratory effort. Conclusions : None of the spontaneous ventilatory methods tested succeeded in reducing the high respiratory drive or muscle effort, and thus potentially promoting P-SILI, regardless of the Ers." @default.
• W4366997681 created "2023-04-27" @default.
• W4366997681 creator A5018374900 @default.
• W4366997681 creator A5033998797 @default.
• W4366997681 creator A5040447853 @default.
• W4366997681 creator A5044873035 @default.
• W4366997681 creator A5049520235 @default.
• W4366997681 creator A5058208458 @default.
• W4366997681 creator A5060073561 @default.
• W4366997681 creator A5064313924 @default.
• W4366997681 creator A5079997314 @default.
• W4366997681 creator A5090640813 @default.
• W4366997681 date "2023-04-25" @default.
• W4366997681 modified "2023-10-18" @default.
• W4366997681 title "Physiological comparison of three spontaneous breathing trials in COVID-19 pneumoniae. Inspiratory effort, and relationship with the different phenotypes. Risk of patient self-inflicted lung injury." @default.
• W4366997681 cites W1968027319 @default.
• W4366997681 cites W2048851927 @default.
• W4366997681 cites W2072378922 @default.
• W4366997681 cites W2162001089 @default.
• W4366997681 cites W2519293880 @default.
• W4366997681 cites W2809044807 @default.
• W4366997681 cites W2811487963 @default.
• W4366997681 cites W2985798828 @default.
• W4366997681 cites W3006991244 @default.
• W4366997681 cites W3012811820 @default.
• W4366997681 cites W3015269808 @default.
• W4366997681 cites W3033237174 @default.
• W4366997681 cites W3080584196 @default.
• W4366997681 cites W3175986085 @default.
• W4366997681 cites W3178592321 @default.
• W4366997681 cites W4293463915 @default.
• W4366997681 doi "https://doi.org/10.21203/rs.3.rs-2814255/v1" @default.
• W4366997681 hasPublicationYear "2023" @default.
• W4366997681 type Work @default.
• W4366997681 citedByCount "0" @default.
• W4366997681 crossrefType "posted-content" @default.
• W4366997681 hasAuthorship W4366997681A5018374900 @default.
• W4366997681 hasAuthorship W4366997681A5033998797 @default.
• W4366997681 hasAuthorship W4366997681A5040447853 @default.
• W4366997681 hasAuthorship W4366997681A5044873035 @default.
• W4366997681 hasAuthorship W4366997681A5049520235 @default.
• W4366997681 hasAuthorship W4366997681A5058208458 @default.
• W4366997681 hasAuthorship W4366997681A5060073561 @default.
• W4366997681 hasAuthorship W4366997681A5064313924 @default.
• W4366997681 hasAuthorship W4366997681A5079997314 @default.
• W4366997681 hasAuthorship W4366997681A5090640813 @default.
• W4366997681 hasBestOaLocation W43669976811 @default.
• W4366997681 hasConcept C126322002 @default.
• W4366997681 hasConcept C127413603 @default.
• W4366997681 hasConcept C200457457 @default.
• W4366997681 hasConcept C27101514 @default.
• W4366997681 hasConcept C2776888751 @default.
• W4366997681 hasConcept C2776924770 @default.
• W4366997681 hasConcept C2777080012 @default.
• W4366997681 hasConcept C2777257755 @default.
• W4366997681 hasConcept C2777421782 @default.
• W4366997681 hasConcept C2777714996 @default.
• W4366997681 hasConcept C2777785262 @default.
• W4366997681 hasConcept C39300077 @default.
• W4366997681 hasConcept C42219234 @default.
• W4366997681 hasConcept C534529494 @default.
• W4366997681 hasConcept C71924100 @default.
• W4366997681 hasConcept C78519656 @default.
• W4366997681 hasConceptScore W4366997681C126322002 @default.
• W4366997681 hasConceptScore W4366997681C127413603 @default.
• W4366997681 hasConceptScore W4366997681C200457457 @default.
• W4366997681 hasConceptScore W4366997681C27101514 @default.
• W4366997681 hasConceptScore W4366997681C2776888751 @default.
• W4366997681 hasConceptScore W4366997681C2776924770 @default.
• W4366997681 hasConceptScore W4366997681C2777080012 @default.
• W4366997681 hasConceptScore W4366997681C2777257755 @default.
• W4366997681 hasConceptScore W4366997681C2777421782 @default.
• W4366997681 hasConceptScore W4366997681C2777714996 @default.
• W4366997681 hasConceptScore W4366997681C2777785262 @default.
• W4366997681 hasConceptScore W4366997681C39300077 @default.
• W4366997681 hasConceptScore W4366997681C42219234 @default.
• W4366997681 hasConceptScore W4366997681C534529494 @default.
• W4366997681 hasConceptScore W4366997681C71924100 @default.
• W4366997681 hasConceptScore W4366997681C78519656 @default.
• W4366997681 hasLocation W43669976811 @default.
• W4366997681 hasOpenAccess W4366997681 @default.
• W4366997681 hasPrimaryLocation W43669976811 @default.
• W4366997681 hasRelatedWork W1486338868 @default.
• W4366997681 hasRelatedWork W2062430808 @default.
• W4366997681 hasRelatedWork W2066163264 @default.
• W4366997681 hasRelatedWork W2078267441 @default.
• W4366997681 hasRelatedWork W2103668181 @default.
• W4366997681 hasRelatedWork W2229361031 @default.
• W4366997681 hasRelatedWork W2377146980 @default.
• W4366997681 hasRelatedWork W2377739500 @default.
• W4366997681 hasRelatedWork W2986305892 @default.
• W4366997681 hasRelatedWork W3085997565 @default.
• W4366997681 isParatext "false" @default.
• W4366997681 isRetracted "false" @default.
• W4366997681 workType "article" @default.