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- W4366997716 abstract "Abstract Cryptococcus spp. are environmental fungi that first must adapt to the host environment before they can cause life-threatening meningitis in immunocompromised patients. Host CO 2 concentrations are 100-fold higher than the external environment and strains unable to grow at host CO 2 concentrations are not pathogenic. Using a genetic screening and transcriptional profiling approach, we found that the TOR pathway is critical for C. neoformans adaptation to host CO 2 partly through Ypk1-dependent remodeling of phosphatidylserine asymmetry at the plasma membrane. We also identified a candidate C. neoformans floppase (Lat1) that is highly expressed in CO 2 -sensitive environmental strains and suppresses CO 2 -induced phosphatidylserine remodeling. Interestingly, regulation of plasma membrane lipid asymmetry by the TOR-Ypk1 axis is distinct in C. neoformans compared to S. cerevisiae . Finally, host CO 2 concentrations suppress the C. neoformans pathways that respond to host temperature (Mpk1) and pH (Rim101), indicating that host adaptation requires a stringent balance among distinct stress responses." @default.
- W4366997716 created "2023-04-27" @default.
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- W4366997716 date "2023-04-25" @default.
- W4366997716 modified "2023-09-23" @default.
- W4366997716 title "The fungal pathogen Cryptococcus neoformans adapts to the host environment through TOR-mediated remodeling of phospholipid asymmetry" @default.
- W4366997716 doi "https://doi.org/10.21203/rs.3.rs-2828872/v1" @default.
- W4366997716 hasPublicationYear "2023" @default.
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