Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366997744> ?p ?o ?g. }
- W4366997744 abstract "Abstract Adhesive interactions between Staphylococcus aureus and the host rely on cell wall-anchored proteins such as fibronectin binding protein B (FnBPB). Recently we showed that the FnBPB protein expressed by clonal complex (CC) 1 isolates of S. aureus mediates bacterial adhesion to corneodesmosin. The proposed ligand binding region of CC1-type FnBPB shares just 60% amino acid identity with the archetypal FnBPB protein from CC8. Here we investigated ligand binding and biofilm formation by CC1-type FnBPB. We found that the A domain of FnBPB binds to fibrinogen and corneodesmosin and identified residues within the hydrophobic ligand trench in the A domain that are essential for the binding of CC1-type FnBPB to ligands and during biofilm formation. We further investigated the interplay between different ligands and the influence of ligand binding on biofilm formation. Overall, our study provides new insights into the requirements for CC1-type FnBPB-mediated adhesion to host proteins and FnBPB-mediated biofilm formation in S. aureus ." @default.
- W4366997744 created "2023-04-27" @default.
- W4366997744 creator A5008842209 @default.
- W4366997744 creator A5063522727 @default.
- W4366997744 date "2023-04-25" @default.
- W4366997744 modified "2023-09-29" @default.
- W4366997744 title "The A domain of clonal complex 1-type fibronectin binding protein B promotes adherence and biofilm formation in<i>Staphylococcus aureus</i>" @default.
- W4366997744 cites W1500769488 @default.
- W4366997744 cites W1501901006 @default.
- W4366997744 cites W1803102843 @default.
- W4366997744 cites W1936624937 @default.
- W4366997744 cites W1973323357 @default.
- W4366997744 cites W1973479917 @default.
- W4366997744 cites W1983957332 @default.
- W4366997744 cites W1997584741 @default.
- W4366997744 cites W2030904449 @default.
- W4366997744 cites W2033099498 @default.
- W4366997744 cites W2039128987 @default.
- W4366997744 cites W2040823934 @default.
- W4366997744 cites W2043839045 @default.
- W4366997744 cites W2048818416 @default.
- W4366997744 cites W2052620064 @default.
- W4366997744 cites W2054861016 @default.
- W4366997744 cites W2063609296 @default.
- W4366997744 cites W2071677554 @default.
- W4366997744 cites W2092614679 @default.
- W4366997744 cites W2106538205 @default.
- W4366997744 cites W2113996889 @default.
- W4366997744 cites W2122158062 @default.
- W4366997744 cites W2137010791 @default.
- W4366997744 cites W2138470479 @default.
- W4366997744 cites W2139877236 @default.
- W4366997744 cites W2460096060 @default.
- W4366997744 cites W2596742043 @default.
- W4366997744 cites W2757862367 @default.
- W4366997744 cites W2909387807 @default.
- W4366997744 cites W2910520458 @default.
- W4366997744 cites W3115370564 @default.
- W4366997744 cites W3177828909 @default.
- W4366997744 cites W3211795435 @default.
- W4366997744 cites W4229050413 @default.
- W4366997744 cites W4306721418 @default.
- W4366997744 doi "https://doi.org/10.1101/2023.04.25.538241" @default.
- W4366997744 hasPublicationYear "2023" @default.
- W4366997744 type Work @default.
- W4366997744 citedByCount "0" @default.
- W4366997744 crossrefType "posted-content" @default.
- W4366997744 hasAuthorship W4366997744A5008842209 @default.
- W4366997744 hasAuthorship W4366997744A5063522727 @default.
- W4366997744 hasBestOaLocation W43669977441 @default.
- W4366997744 hasConcept C107824862 @default.
- W4366997744 hasConcept C116569031 @default.
- W4366997744 hasConcept C1491633281 @default.
- W4366997744 hasConcept C170493617 @default.
- W4366997744 hasConcept C178790620 @default.
- W4366997744 hasConcept C185592680 @default.
- W4366997744 hasConcept C25166345 @default.
- W4366997744 hasConcept C2779489039 @default.
- W4366997744 hasConcept C51639874 @default.
- W4366997744 hasConcept C523546767 @default.
- W4366997744 hasConcept C54355233 @default.
- W4366997744 hasConcept C55493867 @default.
- W4366997744 hasConcept C58123911 @default.
- W4366997744 hasConcept C84416704 @default.
- W4366997744 hasConcept C85789140 @default.
- W4366997744 hasConcept C86492073 @default.
- W4366997744 hasConcept C86803240 @default.
- W4366997744 hasConcept C89423630 @default.
- W4366997744 hasConcept C95444343 @default.
- W4366997744 hasConceptScore W4366997744C107824862 @default.
- W4366997744 hasConceptScore W4366997744C116569031 @default.
- W4366997744 hasConceptScore W4366997744C1491633281 @default.
- W4366997744 hasConceptScore W4366997744C170493617 @default.
- W4366997744 hasConceptScore W4366997744C178790620 @default.
- W4366997744 hasConceptScore W4366997744C185592680 @default.
- W4366997744 hasConceptScore W4366997744C25166345 @default.
- W4366997744 hasConceptScore W4366997744C2779489039 @default.
- W4366997744 hasConceptScore W4366997744C51639874 @default.
- W4366997744 hasConceptScore W4366997744C523546767 @default.
- W4366997744 hasConceptScore W4366997744C54355233 @default.
- W4366997744 hasConceptScore W4366997744C55493867 @default.
- W4366997744 hasConceptScore W4366997744C58123911 @default.
- W4366997744 hasConceptScore W4366997744C84416704 @default.
- W4366997744 hasConceptScore W4366997744C85789140 @default.
- W4366997744 hasConceptScore W4366997744C86492073 @default.
- W4366997744 hasConceptScore W4366997744C86803240 @default.
- W4366997744 hasConceptScore W4366997744C89423630 @default.
- W4366997744 hasConceptScore W4366997744C95444343 @default.
- W4366997744 hasLocation W43669977441 @default.
- W4366997744 hasOpenAccess W4366997744 @default.
- W4366997744 hasPrimaryLocation W43669977441 @default.
- W4366997744 hasRelatedWork W105331437 @default.
- W4366997744 hasRelatedWork W1500769488 @default.
- W4366997744 hasRelatedWork W1987836606 @default.
- W4366997744 hasRelatedWork W2004072428 @default.
- W4366997744 hasRelatedWork W2022807117 @default.
- W4366997744 hasRelatedWork W2060765659 @default.
- W4366997744 hasRelatedWork W2133032561 @default.
- W4366997744 hasRelatedWork W2471751184 @default.
- W4366997744 hasRelatedWork W2895293826 @default.