FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366997833> ?p ?o ?g. }

• W4366997833 abstract "Abstract Malignant pleural mesothelioma (MPM), a rare cancer a long latency period (up to 40 years) between asbestos exposure and disease presentation. The mechanisms coupling asbestos to recurrent somatic alterations are poorly defined. Gene-fusions arising through genomic instability may create novel drivers during early MPM evolution. We explored the gene fusions that occurred early in the evolutionary history. We conducted multiregional whole exome sequencing (WES) of 106 samples from 20 patients undergoing pleurectomy decortication and identified 24 clonal non-recurrent fusions, three of which were novel ( FMO9P-OR2W5 , GBA3 and SP9 ). The number of early gene fusion events detected varied from zero to eight per tumour, and presence of gene fusions was associated with clonal SCNAs involving the Hippo pathway genes and homologous recombination DNA repair genes. Fusions involved known tumour suppressors BAP1 , MTAP , and LRP1B, and a clonal oncogenic fusion involving CACNA1D-ERC2, PARD3B - NT5DC2 and STAB2 - NT5DC2 fusions were also identified as clonal fusions. Gene fusions events occur early during MPM evolution. Individual fusions are rare as no recurrent truncal fusions event were found. This suggests the importance of early disruption of these pathways in generating genomic rearrangements resulting in potentially oncogenic gene fusions." @default.
• W4366997833 created "2023-04-27" @default.
• W4366997833 creator A5007473858 @default.
• W4366997833 creator A5011181919 @default.
• W4366997833 creator A5035399297 @default.
• W4366997833 creator A5036171216 @default.
• W4366997833 creator A5038892498 @default.
• W4366997833 creator A5046007245 @default.
• W4366997833 creator A5048187305 @default.
• W4366997833 creator A5053204257 @default.
• W4366997833 creator A5054800980 @default.
• W4366997833 creator A5072974790 @default.
• W4366997833 date "2023-04-25" @default.
• W4366997833 modified "2023-09-23" @default.
• W4366997833 title "Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways" @default.
• W4366997833 cites W1810761522 @default.
• W4366997833 cites W1982906652 @default.
• W4366997833 cites W1994830891 @default.
• W4366997833 cites W2006752813 @default.
• W4366997833 cites W2007265317 @default.
• W4366997833 cites W2041937775 @default.
• W4366997833 cites W2089483984 @default.
• W4366997833 cites W2102610315 @default.
• W4366997833 cites W2128505445 @default.
• W4366997833 cites W2139676849 @default.
• W4366997833 cites W2146005104 @default.
• W4366997833 cites W2156253686 @default.
• W4366997833 cites W2164749593 @default.
• W4366997833 cites W2169456326 @default.
• W4366997833 cites W2178562114 @default.
• W4366997833 cites W2257573908 @default.
• W4366997833 cites W2287840388 @default.
• W4366997833 cites W2291531085 @default.
• W4366997833 cites W2321587450 @default.
• W4366997833 cites W2329648702 @default.
• W4366997833 cites W2534952667 @default.
• W4366997833 cites W2606899662 @default.
• W4366997833 cites W2765185461 @default.
• W4366997833 cites W2765689414 @default.
• W4366997833 cites W2792186276 @default.
• W4366997833 cites W2796292093 @default.
• W4366997833 cites W2897299514 @default.
• W4366997833 cites W2915524647 @default.
• W4366997833 cites W2994357872 @default.
• W4366997833 cites W3003946104 @default.
• W4366997833 cites W3118238647 @default.
• W4366997833 cites W3121795734 @default.
• W4366997833 cites W3127551105 @default.
• W4366997833 cites W3136769797 @default.
• W4366997833 cites W3166968358 @default.
• W4366997833 cites W3192624751 @default.
• W4366997833 cites W4226287293 @default.
• W4366997833 cites W4281645037 @default.
• W4366997833 cites W4281756014 @default.
• W4366997833 doi "https://doi.org/10.1101/2023.04.20.23288867" @default.
• W4366997833 hasPublicationYear "2023" @default.
• W4366997833 type Work @default.
• W4366997833 citedByCount "0" @default.
• W4366997833 crossrefType "posted-content" @default.
• W4366997833 hasAuthorship W4366997833A5007473858 @default.
• W4366997833 hasAuthorship W4366997833A5011181919 @default.
• W4366997833 hasAuthorship W4366997833A5035399297 @default.
• W4366997833 hasAuthorship W4366997833A5036171216 @default.
• W4366997833 hasAuthorship W4366997833A5038892498 @default.
• W4366997833 hasAuthorship W4366997833A5046007245 @default.
• W4366997833 hasAuthorship W4366997833A5048187305 @default.
• W4366997833 hasAuthorship W4366997833A5053204257 @default.
• W4366997833 hasAuthorship W4366997833A5054800980 @default.
• W4366997833 hasAuthorship W4366997833A5072974790 @default.
• W4366997833 hasBestOaLocation W43669978331 @default.
• W4366997833 hasConcept C104317684 @default.
• W4366997833 hasConcept C111829193 @default.
• W4366997833 hasConcept C113968399 @default.
• W4366997833 hasConcept C143425029 @default.
• W4366997833 hasConcept C178169997 @default.
• W4366997833 hasConcept C37846818 @default.
• W4366997833 hasConcept C502942594 @default.
• W4366997833 hasConcept C54355233 @default.
• W4366997833 hasConcept C552990157 @default.
• W4366997833 hasConcept C86803240 @default.
• W4366997833 hasConcept C99983632 @default.
• W4366997833 hasConceptScore W4366997833C104317684 @default.
• W4366997833 hasConceptScore W4366997833C111829193 @default.
• W4366997833 hasConceptScore W4366997833C113968399 @default.
• W4366997833 hasConceptScore W4366997833C143425029 @default.
• W4366997833 hasConceptScore W4366997833C178169997 @default.
• W4366997833 hasConceptScore W4366997833C37846818 @default.
• W4366997833 hasConceptScore W4366997833C502942594 @default.
• W4366997833 hasConceptScore W4366997833C54355233 @default.
• W4366997833 hasConceptScore W4366997833C552990157 @default.
• W4366997833 hasConceptScore W4366997833C86803240 @default.
• W4366997833 hasConceptScore W4366997833C99983632 @default.
• W4366997833 hasLocation W43669978331 @default.
• W4366997833 hasOpenAccess W4366997833 @default.
• W4366997833 hasPrimaryLocation W43669978331 @default.
• W4366997833 hasRelatedWork W2035020647 @default.
• W4366997833 hasRelatedWork W2091055693 @default.
• W4366997833 hasRelatedWork W2093310335 @default.
• W4366997833 hasRelatedWork W2319371655 @default.
• W4366997833 hasRelatedWork W2478170669 @default.

• next