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- W4366997838 abstract "Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome inheritance. CENP-E (kinesin 7) and Dynein-Dynactin (DD), microtubule motors with opposite polarity, promote biorientation from the kinetochore corona, a polymeric structure whose assembly requires MPS1 kinase. The corona’s building block consists of ROD, Zwilch, ZW10, and the DD adaptor Spindly (RZZS). How CENP-E and DD are scaffolded and mutually coordinated in the corona remains unclear. Here, we report near-complete depletion of RZZS and DD from kinetochores after depletion of CENP-E and the outer kinetochore protein KNL1. With inhibited MPS1, CENP-E, which we show binds directly to RZZS, is required to retain kinetochore RZZS. An RZZS phosphomimetic mutant bypasses this requirement. With active MPS1, CENP-E is dispensable for corona expansion, but strictly required for physiological kinetochore accumulation of DD. Thus, we identify the corona as an integrated scaffold where CENP-E kinesin controls DD kinetochore loading for coordinated bidirectional transport of chromosome cargo." @default.
- W4366997838 created "2023-04-27" @default.
- W4366997838 creator A5006549305 @default.
- W4366997838 creator A5020601579 @default.
- W4366997838 creator A5020711185 @default.
- W4366997838 creator A5021703500 @default.
- W4366997838 creator A5027221424 @default.
- W4366997838 creator A5073374028 @default.
- W4366997838 creator A5073503402 @default.
- W4366997838 date "2023-04-25" @default.
- W4366997838 modified "2023-10-01" @default.
- W4366997838 title "A mechanism that integrates microtubule motors of opposite polarity at the kinetochore corona" @default.
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