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- W4366997916 abstract "Abstract Little is known about tissue specific changes that occur with aging in humans. Using the description of 33 million histological samples we extract thousands of age- and mortality-associated features from text narratives that we call The Human Pathome (pathoage.com). Notably, we can determine when pathological aging starts at the organism and tissue level, indicating a sexual dimorphism with females aging earlier but slower and males aging later but faster. We employ unsupervised topic-modelling to identify terms and themes that predict age and mortality. As a proof of principle, we cross reference these terms in PubMed to identify nintedanib as a potential aging intervention and show that nintedanib reduces markers of cellular senescence, reduces pro-fibrotic gene pathways in senescent cells and extends the lifespan of fruit flies. Our findings pave the way for expanded exploitation of population datasets towards discovery of novel aging interventions." @default.
- W4366997916 created "2023-04-27" @default.
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- W4366997916 date "2023-04-26" @default.
- W4366997916 modified "2023-10-14" @default.
- W4366997916 title "The human pathome shows sex and tissue specific aging patterns" @default.
- W4366997916 doi "https://doi.org/10.21203/rs.3.rs-2652110/v1" @default.
- W4366997916 hasPublicationYear "2023" @default.
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