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• W4366997938 abstract "Abstract Doxorubicin (Dox) is cardiotoxicity is established while chromium 6 + compound (Cr[VI]) could be cardiotoxic due to its bioaccumulation capacity. This study compared vehicle, dose, and duration-related oxidative, cardiotoxic, inflammatory and histologic responses of Cr[VI] and Dox intoxication in rats’ heart by standard protocols. The rats were respectively intoxicated with Cr [VI] and Dox in 3 different phases. In the first phase, sixty rats were assigned to six groups of ten each. Group 1 served as the Control while groups 2, 3, and 4 were treated with oral doses of 10, 20, and 30 mg/kg body weight (b.wt) of K 2 Cr 2 O 7 (Cr[VI]) solution while groups 5 and 6 received intraperitoneal administration of 15 and 20 mg/kg b.wt Dox for two days, respectively, before the sacrifice. The procedure was repeated in the second and third Phases, but for 60 days. Oxidative, cardiotoxic, inflammatory and histologic indices were determined in the rats’ heart. The results indicated that exposure to either Dox or Cr{VI] caused a significant ( P < 0.05) dose, vehicle and duration-dependent decrease in Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Catalase (CAT) activities and Nitric Oxide(NO) levels but an increase in Cardiac Troponin (CTnI) levels, Creatinine-kinase (CK-MB), C-reactive protein(CRP), Aspartate-transaminase(AST), Lactate-dehydrogenase (LDH) and Malondialdehyde (MDA) compared to the control. Heart histopathology of Dox- and Cr[VI] treated rats showed dose, vehicle and duration-dependent pulmonary oedema, hyaline necrosis and displacement of adjacent myocytes compared to control. Thus, Cr[VI] compared well with Dox in cardiotoxicity induction accompanied with oxidative stress, inflammatory and histo-hepatic responses in the rats’ heart." @default.
• W4366997938 created "2023-04-27" @default.
• W4366997938 creator A5027818399 @default.
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• W4366997938 date "2023-04-25" @default.
• W4366997938 modified "2023-10-04" @default.
• W4366997938 title "Comparative Evaluation of Vehicle, Dose, and Duration-related Oxidative, Cardiotoxic, Inflammatory and Histologic Responses of Chromium 6+ and Doxorubicin in Rats’ Heart" @default.
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• W4366997938 cites W1966630345 @default.
• W4366997938 cites W1981418692 @default.
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• W4366997938 cites W1997687927 @default.
• W4366997938 cites W2011734885 @default.
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• W4366997938 cites W2038807714 @default.
• W4366997938 cites W2049573968 @default.
• W4366997938 cites W2050150374 @default.
• W4366997938 cites W2054749622 @default.
• W4366997938 cites W2075493642 @default.
• W4366997938 cites W2083028740 @default.
• W4366997938 cites W2091732904 @default.
• W4366997938 cites W2096795975 @default.
• W4366997938 cites W2101149478 @default.
• W4366997938 cites W2102068176 @default.
• W4366997938 cites W2112027843 @default.
• W4366997938 cites W2122189144 @default.
• W4366997938 cites W2123474366 @default.
• W4366997938 cites W2127290454 @default.
• W4366997938 cites W2133042655 @default.
• W4366997938 cites W2138504069 @default.
• W4366997938 cites W2147582630 @default.
• W4366997938 cites W2154758118 @default.
• W4366997938 cites W2160099189 @default.
• W4366997938 cites W2160278112 @default.
• W4366997938 cites W2167251312 @default.
• W4366997938 cites W2263023695 @default.
• W4366997938 cites W2286748995 @default.
• W4366997938 cites W2309517590 @default.
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• W4366997938 cites W2755269296 @default.
• W4366997938 cites W2761685840 @default.
• W4366997938 cites W2765352371 @default.
• W4366997938 cites W2765729966 @default.
• W4366997938 cites W2791340070 @default.
• W4366997938 cites W2797157323 @default.
• W4366997938 cites W2799881750 @default.
• W4366997938 cites W2800942502 @default.
• W4366997938 cites W2801820093 @default.
• W4366997938 cites W2806021996 @default.
• W4366997938 cites W2889079772 @default.
• W4366997938 cites W2914973613 @default.
• W4366997938 cites W2929061705 @default.
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• W4366997938 cites W2946000104 @default.
• W4366997938 cites W2946185588 @default.
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• W4366997938 cites W2969128576 @default.
• W4366997938 cites W2970308936 @default.
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• W4366997938 cites W3007286864 @default.
• W4366997938 cites W3008977195 @default.
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• W4366997938 cites W3118583265 @default.
• W4366997938 cites W3133013600 @default.
• W4366997938 cites W3133749609 @default.
• W4366997938 cites W3154539815 @default.
• W4366997938 cites W3159835571 @default.
• W4366997938 cites W3161266816 @default.
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• W4366997938 cites W3198474179 @default.
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• W4366997938 cites W4214762586 @default.
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• W4366997938 cites W4231641807 @default.
• W4366997938 cites W4235115246 @default.
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• W4366997938 doi "https://doi.org/10.21203/rs.3.rs-2847266/v1" @default.
• W4366997938 hasPublicationYear "2023" @default.
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