Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366998066> ?p ?o ?g. }
- W4366998066 abstract "Abstract We sought to investigate the utility of ebastine (EBA), a second-generation antihistamine with potent anti-metastatic properties, in the context of breast cancer stem cell (BCSC)-suppression in triple-negative breast cancer (TNBC). EBA binds to the tyrosine kinase domain of focal adhesion kinase (FAK), blocking phosphorylation at the Y397 and Y576/577 residues. FAK-mediated JAK2/STAT3 and MEK/ERK signaling was attenuated after EBA challenge in vitro and in vivo. EBA treatment induced apoptosis and a sharp decline in the expression of the BCSC markers ALDH1, CD44 and CD49f, suggesting that EBA targets BCSC-like cell populations while reducing tumor bulk. EBA administration significantly impeded BCSC-enriched tumor burden, angiogenesis and distant metastasis while reducing MMP-2/-9 levels in circulating blood in vivo. Our findings suggest that EBA may represent an effective therapeutic for the simultaneous targeting of JAK2/STAT3 and MEK/ERK for the treatment of molecularly heterogeneous TNBC with divergent profiles. Further investigation of EBA as an anti-metastatic agent for the treatment of TNBC is warranted." @default.
- W4366998066 created "2023-04-27" @default.
- W4366998066 creator A5003116915 @default.
- W4366998066 creator A5016426539 @default.
- W4366998066 creator A5021861062 @default.
- W4366998066 creator A5023349445 @default.
- W4366998066 creator A5030853463 @default.
- W4366998066 creator A5036528705 @default.
- W4366998066 creator A5042162830 @default.
- W4366998066 creator A5045481754 @default.
- W4366998066 creator A5049616576 @default.
- W4366998066 creator A5058015319 @default.
- W4366998066 creator A5072548045 @default.
- W4366998066 creator A5075425803 @default.
- W4366998066 creator A5075920991 @default.
- W4366998066 creator A5089793438 @default.
- W4366998066 date "2023-04-25" @default.
- W4366998066 modified "2023-10-15" @default.
- W4366998066 title "Ebastine impairs metastatic spread in triple-negative breast cancer by targeting focal adhesion kinase" @default.
- W4366998066 cites W1161159 @default.
- W4366998066 cites W1857266517 @default.
- W4366998066 cites W1931245889 @default.
- W4366998066 cites W1964020745 @default.
- W4366998066 cites W1971303929 @default.
- W4366998066 cites W1975113490 @default.
- W4366998066 cites W1999435920 @default.
- W4366998066 cites W2003298858 @default.
- W4366998066 cites W2014540164 @default.
- W4366998066 cites W2016512775 @default.
- W4366998066 cites W2023316892 @default.
- W4366998066 cites W2023427658 @default.
- W4366998066 cites W2029606710 @default.
- W4366998066 cites W2037015024 @default.
- W4366998066 cites W2043740205 @default.
- W4366998066 cites W2044423100 @default.
- W4366998066 cites W2053431943 @default.
- W4366998066 cites W2064177371 @default.
- W4366998066 cites W2100996687 @default.
- W4366998066 cites W2137586381 @default.
- W4366998066 cites W2170602872 @default.
- W4366998066 cites W2310034942 @default.
- W4366998066 cites W2402636472 @default.
- W4366998066 cites W2418763476 @default.
- W4366998066 cites W2800784043 @default.
- W4366998066 cites W2891572542 @default.
- W4366998066 cites W2919016311 @default.
- W4366998066 cites W3025903676 @default.
- W4366998066 cites W3039977092 @default.
- W4366998066 cites W3043199384 @default.
- W4366998066 cites W3082619021 @default.
- W4366998066 cites W3147142721 @default.
- W4366998066 cites W3165869767 @default.
- W4366998066 cites W3196491434 @default.
- W4366998066 cites W4220752582 @default.
- W4366998066 cites W4223515068 @default.
- W4366998066 cites W4225277224 @default.
- W4366998066 cites W4307703882 @default.
- W4366998066 doi "https://doi.org/10.1007/s00018-023-04760-5" @default.
- W4366998066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37185776" @default.
- W4366998066 hasPublicationYear "2023" @default.
- W4366998066 type Work @default.
- W4366998066 citedByCount "1" @default.
- W4366998066 countsByYear W43669980662023 @default.
- W4366998066 crossrefType "journal-article" @default.
- W4366998066 hasAuthorship W4366998066A5003116915 @default.
- W4366998066 hasAuthorship W4366998066A5016426539 @default.
- W4366998066 hasAuthorship W4366998066A5021861062 @default.
- W4366998066 hasAuthorship W4366998066A5023349445 @default.
- W4366998066 hasAuthorship W4366998066A5030853463 @default.
- W4366998066 hasAuthorship W4366998066A5036528705 @default.
- W4366998066 hasAuthorship W4366998066A5042162830 @default.
- W4366998066 hasAuthorship W4366998066A5045481754 @default.
- W4366998066 hasAuthorship W4366998066A5049616576 @default.
- W4366998066 hasAuthorship W4366998066A5058015319 @default.
- W4366998066 hasAuthorship W4366998066A5072548045 @default.
- W4366998066 hasAuthorship W4366998066A5075425803 @default.
- W4366998066 hasAuthorship W4366998066A5075920991 @default.
- W4366998066 hasAuthorship W4366998066A5089793438 @default.
- W4366998066 hasBestOaLocation W43669980661 @default.
- W4366998066 hasConcept C121608353 @default.
- W4366998066 hasConcept C126322002 @default.
- W4366998066 hasConcept C1491633281 @default.
- W4366998066 hasConcept C150903083 @default.
- W4366998066 hasConcept C151166631 @default.
- W4366998066 hasConcept C184235292 @default.
- W4366998066 hasConcept C207001950 @default.
- W4366998066 hasConcept C2779013556 @default.
- W4366998066 hasConcept C2780110267 @default.
- W4366998066 hasConcept C2780394083 @default.
- W4366998066 hasConcept C2780932548 @default.
- W4366998066 hasConcept C2781230642 @default.
- W4366998066 hasConcept C2781249067 @default.
- W4366998066 hasConcept C42362537 @default.
- W4366998066 hasConcept C502942594 @default.
- W4366998066 hasConcept C530470458 @default.
- W4366998066 hasConcept C55493867 @default.
- W4366998066 hasConcept C57074206 @default.
- W4366998066 hasConcept C62478195 @default.
- W4366998066 hasConcept C71924100 @default.
- W4366998066 hasConcept C86803240 @default.