FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366998168> ?p ?o ?g. }

• W4366998168 abstract "ABSTRACT Background and Aims Previous trials evaluating remote ischaemic preconditioning in children undergoing cardiac surgery showed mixed results. We sought to determine whether adequately delivered bilateral preconditioning is cardioprotective in young children, with or without cyanosis, undergoing surgery. Methods Prospective, double-blind, randomised controlled trial at two UK centres. Children aged 3-36 months undergoing tetralogy of Fallot repair or ventricular septal defect closure were randomised in a 1:1 ratio to receive either bilateral preconditioning or sham intervention. Participants were followed up until hospital discharge or 30 days. The primary outcome was area under the curve for high-sensitivity troponin-T in the first 24 hours after surgery, analysed by intention-to-treat. Right atrial biopsies were obtained in selected patients. Trial registration: ISRCTN12923441 . Results Between 24 October 2016 and 8 December 2020, 120 eligible children were randomised to receive either bilateral preconditioning (n=60) or sham intervention (n=60). Participants had a median age of 7 months and 42 (35%) were female. The primary outcome, area under the curve for hs-troponin-T was higher in the preconditioning group (mean: 70.0±50.9µg/L/hr, n=56) than in controls (mean: 55.6±30.1µg/L/hr, n=58), p=0.04. Sub-group analyses did not show a differential treatment effect by oxygen saturations (p interaction =0.25) but showed evidence of differential treatment effect by underlying defect (p interaction =0.04). Myocardial metabolism, quantified in atrial biopsies, and secondary outcomes were not different between randomised groups. Conclusions Bilateral remote ischemic preconditioning does not attenuate myocardial injury in children undergoing surgical repair for congenital heart defects, and there was evidence of potential harm in unstented tetralogy of Fallot." @default.
• W4366998168 created "2023-04-27" @default.
• W4366998168 creator A5009386761 @default.
• W4366998168 creator A5015056820 @default.
• W4366998168 creator A5018550930 @default.
• W4366998168 creator A5019715830 @default.
• W4366998168 creator A5021811898 @default.
• W4366998168 creator A5024877159 @default.
• W4366998168 creator A5025526658 @default.
• W4366998168 creator A5025554672 @default.
• W4366998168 creator A5028610354 @default.
• W4366998168 creator A5034447461 @default.
• W4366998168 creator A5035881203 @default.
• W4366998168 creator A5036736922 @default.
• W4366998168 creator A5037441894 @default.
• W4366998168 creator A5039644412 @default.
• W4366998168 creator A5040082126 @default.
• W4366998168 creator A5045453741 @default.
• W4366998168 creator A5047325459 @default.
• W4366998168 creator A5052903580 @default.
• W4366998168 creator A5056329957 @default.
• W4366998168 creator A5057189590 @default.
• W4366998168 creator A5057597018 @default.
• W4366998168 creator A5060272960 @default.
• W4366998168 creator A5069557561 @default.
• W4366998168 creator A5075922879 @default.
• W4366998168 creator A5077245272 @default.
• W4366998168 creator A5082395364 @default.
• W4366998168 creator A5088795321 @default.
• W4366998168 creator A5091024912 @default.
• W4366998168 date "2023-04-25" @default.
• W4366998168 modified "2023-10-16" @default.
• W4366998168 title "The Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery" @default.
• W4366998168 cites W125028120 @default.
• W4366998168 cites W1824177875 @default.
• W4366998168 cites W1969440085 @default.
• W4366998168 cites W1974196730 @default.
• W4366998168 cites W1992979550 @default.
• W4366998168 cites W1999126214 @default.
• W4366998168 cites W2002926363 @default.
• W4366998168 cites W2025756729 @default.
• W4366998168 cites W2028746004 @default.
• W4366998168 cites W2041960220 @default.
• W4366998168 cites W2043723333 @default.
• W4366998168 cites W2043759286 @default.
• W4366998168 cites W2044082115 @default.
• W4366998168 cites W2082327290 @default.
• W4366998168 cites W2085202365 @default.
• W4366998168 cites W2090146220 @default.
• W4366998168 cites W2099501766 @default.
• W4366998168 cites W2100175170 @default.
• W4366998168 cites W2103606060 @default.
• W4366998168 cites W2105443169 @default.
• W4366998168 cites W2109442907 @default.
• W4366998168 cites W2117094658 @default.
• W4366998168 cites W2119347502 @default.
• W4366998168 cites W2122091775 @default.
• W4366998168 cites W2122913928 @default.
• W4366998168 cites W2129561999 @default.
• W4366998168 cites W2130064493 @default.
• W4366998168 cites W2136272230 @default.
• W4366998168 cites W2151231511 @default.
• W4366998168 cites W2154381681 @default.
• W4366998168 cites W2266610498 @default.
• W4366998168 cites W2325867355 @default.
• W4366998168 cites W2330031690 @default.
• W4366998168 cites W2332389703 @default.
• W4366998168 cites W2346437601 @default.
• W4366998168 cites W2591478754 @default.
• W4366998168 cites W2768987876 @default.
• W4366998168 cites W2782093935 @default.
• W4366998168 cites W2888543854 @default.
• W4366998168 cites W2995726651 @default.
• W4366998168 cites W3023567691 @default.
• W4366998168 cites W3092233120 @default.
• W4366998168 cites W3117187956 @default.
• W4366998168 cites W4311118797 @default.
• W4366998168 doi "https://doi.org/10.1101/2023.04.21.23288646" @default.
• W4366998168 hasPublicationYear "2023" @default.
• W4366998168 type Work @default.
• W4366998168 citedByCount "0" @default.
• W4366998168 crossrefType "posted-content" @default.
• W4366998168 hasAuthorship W4366998168A5009386761 @default.
• W4366998168 hasAuthorship W4366998168A5015056820 @default.
• W4366998168 hasAuthorship W4366998168A5018550930 @default.
• W4366998168 hasAuthorship W4366998168A5019715830 @default.
• W4366998168 hasAuthorship W4366998168A5021811898 @default.
• W4366998168 hasAuthorship W4366998168A5024877159 @default.
• W4366998168 hasAuthorship W4366998168A5025526658 @default.
• W4366998168 hasAuthorship W4366998168A5025554672 @default.
• W4366998168 hasAuthorship W4366998168A5028610354 @default.
• W4366998168 hasAuthorship W4366998168A5034447461 @default.
• W4366998168 hasAuthorship W4366998168A5035881203 @default.
• W4366998168 hasAuthorship W4366998168A5036736922 @default.
• W4366998168 hasAuthorship W4366998168A5037441894 @default.
• W4366998168 hasAuthorship W4366998168A5039644412 @default.
• W4366998168 hasAuthorship W4366998168A5040082126 @default.
• W4366998168 hasAuthorship W4366998168A5045453741 @default.
• W4366998168 hasAuthorship W4366998168A5047325459 @default.
• W4366998168 hasAuthorship W4366998168A5052903580 @default.

• next