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• W4366998217 abstract "Abstract Background Caregiver burden is related to personal factors and patient characteristics and is greater when neuropsychiatric symptoms (NPSs) are present. Objective: Estimate the prevalence of burden among caregivers of dementia patients and its association with NPSs and identify NPSs causing greater caregiver distress according to dementia stage. Methods Cross-sectional observational study in caregivers of noninstitutionalized dementia patients. Caregiver variables: sociodemographic, time of care, NPS-associated distress based on the Neuropsychiatric Inventory Caregiver Distress Scale (NPI-D) and burden based on the Zarit Burden Interview (ZBI). Patient variables: time since disease onset, Global Deterioration Scale (GDS) disease stage, functional assessment and NPS presence and intensity according to the Neuropsychiatric Inventory (NPI). The mean ZBI score, prevalence of burden and NPI-D score with 95% CIs at each dementia stage were estimated. Factors associated with burden were identified by multivariate analysis. Results Of the 125 caregivers included, 77.6% were women, with a mean age of 60.7 (± 14.3) years; 78.4% (95% CI: 71.0; 86.0) experienced burden. The mean ZBI score was 12.3 (95% CI: 11.6; 12.9) and increased according to NPS number (p = 0.042). The NPSs causing the most burden were disinhibition (93.5%), irritability (87.3%) and agitation (86.1%). Agitation, apathy, and sleep disorders were the NPSs generating the greatest overall caregiver distress; depression (max NPI-D 1.9), hyperactivity (max NPI-D 2.1), and psychosis symptoms (max NPI-D 1.6) generated the greatest distress at stage GDS 3, stages GDS 4–5, and stages GDS 6–7, respectively. The NPI score (OR = 1.0, 95% CI 1.0; 1.1), intensity of irritability (OR = 1.3, 95% CI 1.0; 1.6), disinhibition (OR = 2.3, 95% CI 1.1; 5.2) and hyperactivity subsyndrome (OR = 1.1, 95% CI 1.0; 1.2) were associated with caregiver burden. Other associated factors were female gender (OR = 6.0, 95% CI 1.6; 22.8), ≥ 8 hours daily care (OR = 5.6, 95% CI 1.4; 22.8), working outside the home (OR = 7.6, 95% CI 1.8; 31.8), living with the patient (OR = 4.5, 95% CI 1.1; 19.6), kinship (OR = 5.4, 95% CI 1.0; 28.2) and lower patient education (OR = 8.3, 95% CI 2.3; 30.3). Conclusions The burden on caregivers of dementia patients is high and associated with NPS presence and intensity. Disinhibition and irritability caused the highest burden. Depression, hyperactivity and psychosis produce more distress in mild, mild-moderate and severe dementia, respectively." @default.
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• W4366998217 date "2023-04-25" @default.
• W4366998217 modified "2023-09-27" @default.
• W4366998217 title "Burden in caregivers of primary care patients with dementia: Influence of neuropsychiatric symptoms according to disease stage (NeDEM project)" @default.
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• W4366998217 doi "https://doi.org/10.21203/rs.3.rs-2804261/v1" @default.
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