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• W4366998401 abstract "Abstract BACKGROUND: Previous studies have suggested that nucleus pulposus degeneration is accompanied by neutrophil infiltration and that inflammatory factors released by neutrophils play an important role in the process of nucleus pulposus degeneration. A study to characterize neutrophils in degenerating myeloid tissue is lacking. METHODS: We downloaded a single cell sequencing data of degenerated nucleus pulposus from a public database. The single-cell expression profile of the degenerated nucleus pulposus was constructed by software analysis for cell filtering, data normalization, cell subcluster analysis, and cell type identification procedures, and marker genes for cell subclusters were obtained. The functions of different cell subclusters in the degeneration process were then further explored by using gene function analysis, signaling pathway analysis, and pseudo time analysis. Finally, we characterized the neutrophils in the degenerative nucleus pulposus tissue. RESULTS: A single-cell atlas of 4774 cells was constructed by transcriptome sequencing of the degenerated nucleus pulposus tissue. All cells were classified into cell types, and two major cell types, nucleus pulposus chondrocytes and neutrophils, were identified in the degenerated nucleus pulposus tissue, and the functions of different subclusters were enriched and analyzed, and key genes were extracted for biological function analysis. A pseudo time analysis was performed on the degenerated nucleus pulposus chondrocytes, and key nodes were selected for the study to analyze the changing relationships among the three chondrocyte subclusters. The infiltration of neutrophils in the degenerated nucleus pulposus was revealed from a single cell dimension. Key genes were extracted from neutrophils in degenerated nucleus pulposus tissue to characterize the biological functions of neutrophils. CONCLUSIONS: Three subclusters of nucleus pulposus chondrocytes and neutrophils were identified. The different functions of the 3 types of nucleus pulposus chondrocytes were also derived. Among them, calcification-inhibited nucleus pulposus chondrocytes were the main responsible cell cluster for nucleus pulposus degeneration, and the steady-state cells still performed the normal nucleus pulposus chondrocyte function. The phenomenon of neutrophil infiltration in intervertebral disc tissue was revealed for the first time from a single cell dimension, and key genes were extracted to investigate the cellular functions of infiltrating neutrophils in degenerated nucleus pulposus tissue." @default.
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• W4366998401 date "2023-04-25" @default.
• W4366998401 modified "2023-09-23" @default.
• W4366998401 title "Single-cell transcriptome sequencing reveals neutrophil infiltration in degenerative nucleus pulposus tissue" @default.
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• W4366998401 doi "https://doi.org/10.21203/rs.3.rs-2823429/v1" @default.
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