FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366998663> ?p ?o ?g. }

• W4366998663 abstract "Abstract Background Midodrine is occasionally used off-label to treat hypotension associated with advanced heart failure. Its association with changes in prescription of guideline-directed medical therapy (GDMT) has not previously been evaluated. Objectives We sought to evaluate the clinical characteristics and GDMT prescriptions of heart failure patients who were prescribed midodrine. Methods We performed a retrospective cohort study identifying all patients admitted to our hospital in 2020 with decompensated systolic heart failure who were prescribed midodrine upon discharge. They were compared to decompensated systolic heart failure patients who were not prescribed midodrine. Baseline characteristics, GDMT adjustments, and clinical outcomes were collected. Results 114 patients met inclusion criteria in the midodrine group and were compared to 358 patients in the control group. At baseline, the midodrine group had worse left ventricular function, more right ventricular dysfunction, and more severe heart failure symptoms. At 6-months, the midodrine group had more initiation or up-titration of beta blockers (24.6% vs.15.4%; p=0.035), renin-angiotensin-aldosterone system (RAAS) inhibitors (34.2% vs. 24.0%; p=0.043) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) (19.3% vs.10.6%; p=0.024) compared to the non-midodrine group, with a similar pattern for MRA (mineralocorticoid receptor antagonists) prescriptions (17.5% vs. 11.5%; p=0.126). Mortality was not statistically different between the two groups, but the midodrine group had more frequent re-hospitalization for heart failure (39.5% vs. 25.4%; p=0.006). Conclusions Midodrine is frequently prescribed to patients presenting with systolic heart failure; the patients given midodrine tended to have more advanced heart failure and worse 6-month clinical outcomes. However, the patients who were prescribed midodrine achieved better initiation and up-titration of GDMT at 6 months compared to those who were not prescribed midodrine. Future prospective clinical trials are warranted to confirm these findings and determine if this translates to improved clinical outcomes." @default.
• W4366998663 created "2023-04-27" @default.
• W4366998663 creator A5005735968 @default.
• W4366998663 creator A5022499631 @default.
• W4366998663 creator A5027772798 @default.
• W4366998663 creator A5037978449 @default.
• W4366998663 creator A5071472242 @default.
• W4366998663 creator A5081218583 @default.
• W4366998663 creator A5081928569 @default.
• W4366998663 date "2023-04-25" @default.
• W4366998663 modified "2023-09-26" @default.
• W4366998663 title "The Impact of Midodrine On Guideline-Directed Medical Therapy in Patients Admitted with Systolic Heart Failure" @default.
• W4366998663 cites W1972432424 @default.
• W4366998663 cites W2008805666 @default.
• W4366998663 cites W2039006773 @default.
• W4366998663 cites W2050856345 @default.
• W4366998663 cites W2769418908 @default.
• W4366998663 cites W2883756867 @default.
• W4366998663 cites W2944434778 @default.
• W4366998663 cites W3086163855 @default.
• W4366998663 cites W4206159607 @default.
• W4366998663 cites W4292022394 @default.
• W4366998663 cites W4304136684 @default.
• W4366998663 cites W4308471536 @default.
• W4366998663 doi "https://doi.org/10.1101/2023.04.21.23288945" @default.
• W4366998663 hasPublicationYear "2023" @default.
• W4366998663 type Work @default.
• W4366998663 citedByCount "0" @default.
• W4366998663 crossrefType "posted-content" @default.
• W4366998663 hasAuthorship W4366998663A5005735968 @default.
• W4366998663 hasAuthorship W4366998663A5022499631 @default.
• W4366998663 hasAuthorship W4366998663A5027772798 @default.
• W4366998663 hasAuthorship W4366998663A5037978449 @default.
• W4366998663 hasAuthorship W4366998663A5071472242 @default.
• W4366998663 hasAuthorship W4366998663A5081218583 @default.
• W4366998663 hasAuthorship W4366998663A5081928569 @default.
• W4366998663 hasBestOaLocation W43669986631 @default.
• W4366998663 hasConcept C126322002 @default.
• W4366998663 hasConcept C164705383 @default.
• W4366998663 hasConcept C2426938 @default.
• W4366998663 hasConcept C2777363265 @default.
• W4366998663 hasConcept C2778198053 @default.
• W4366998663 hasConcept C2780081974 @default.
• W4366998663 hasConcept C71924100 @default.
• W4366998663 hasConcept C73787029 @default.
• W4366998663 hasConcept C84393581 @default.
• W4366998663 hasConcept C98274493 @default.
• W4366998663 hasConceptScore W4366998663C126322002 @default.
• W4366998663 hasConceptScore W4366998663C164705383 @default.
• W4366998663 hasConceptScore W4366998663C2426938 @default.
• W4366998663 hasConceptScore W4366998663C2777363265 @default.
• W4366998663 hasConceptScore W4366998663C2778198053 @default.
• W4366998663 hasConceptScore W4366998663C2780081974 @default.
• W4366998663 hasConceptScore W4366998663C71924100 @default.
• W4366998663 hasConceptScore W4366998663C73787029 @default.
• W4366998663 hasConceptScore W4366998663C84393581 @default.
• W4366998663 hasConceptScore W4366998663C98274493 @default.
• W4366998663 hasLocation W43669986631 @default.
• W4366998663 hasOpenAccess W4366998663 @default.
• W4366998663 hasPrimaryLocation W43669986631 @default.
• W4366998663 hasRelatedWork W1998556240 @default.
• W4366998663 hasRelatedWork W2012241433 @default.
• W4366998663 hasRelatedWork W2125804349 @default.
• W4366998663 hasRelatedWork W2360360038 @default.
• W4366998663 hasRelatedWork W2369711294 @default.
• W4366998663 hasRelatedWork W2378416095 @default.
• W4366998663 hasRelatedWork W2389061016 @default.
• W4366998663 hasRelatedWork W2763805509 @default.
• W4366998663 hasRelatedWork W4247718175 @default.
• W4366998663 hasRelatedWork W4313444034 @default.
• W4366998663 isParatext "false" @default.
• W4366998663 isRetracted "false" @default.
• W4366998663 workType "article" @default.