FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366998698> ?p ?o ?g. }

• W4366998698 abstract "Abstract Humans, more than all other species, skillfully flex and extend their fingers to perform delicate motor tasks. This unique dexterous ability is a product of the complex anatomical properties of the human hand and the neural mechanisms that control it. Yet, the neural basis that underlies human dexterous hand movement remains unclear. Here we characterized individuation (fine control) and strength (gross control) during flexion and extension finger movements, isolated the peripheral passive mechanical coupling component from the central neuromuscular activity involved in dexterity and then applied voxel-based lesion mapping in first-event sub-acute stroke patients to investigate the causal link between the neural substrates and the behavioral aspects of finger dexterity. We found substantial differences in dexterous behavior, favoring finger flexion over extension. These differences were not caused by peripheral factors but were rather driven by central origins. Lesion-symptom mapping identified a critical brain region for finger individuation within the primary sensory-motor cortex (M1, S1), the premotor cortex (PMC), and the corticospinal (CST) fibers that descend from them. Although there was a great deal of overlap between individuated flexion and extension, we were able to identify distinct areas within this region that were associated exclusively with finger flexion. This flexion-biased differential premotor and motor cortical organization was associated with the finger individuation component, but not with finger strength. Conversely, lesion mapping revealed slight extension-biases in finger strength within descending tracts of M1. From these results we propose a model that summarizes the distinctions between individuation and strength and between finger movement in flexion and extension, revealed in human manual dexterity." @default.
• W4366998698 created "2023-04-27" @default.
• W4366998698 creator A5002797766 @default.
• W4366998698 creator A5009936419 @default.
• W4366998698 creator A5012186065 @default.
• W4366998698 creator A5014154314 @default.
• W4366998698 creator A5036767078 @default.
• W4366998698 creator A5049209092 @default.
• W4366998698 creator A5049845557 @default.
• W4366998698 creator A5051342198 @default.
• W4366998698 creator A5069232355 @default.
• W4366998698 creator A5080881487 @default.
• W4366998698 date "2023-04-25" @default.
• W4366998698 modified "2023-09-23" @default.
• W4366998698 title "Direction-dependent neural control of finger dexterity in humans" @default.
• W4366998698 cites W1219677739 @default.
• W4366998698 cites W126354016 @default.
• W4366998698 cites W1963493066 @default.
• W4366998698 cites W1970928383 @default.
• W4366998698 cites W1973409739 @default.
• W4366998698 cites W1976686479 @default.
• W4366998698 cites W1979947358 @default.
• W4366998698 cites W1982750178 @default.
• W4366998698 cites W1990729767 @default.
• W4366998698 cites W1991396150 @default.
• W4366998698 cites W1995957606 @default.
• W4366998698 cites W2006428502 @default.
• W4366998698 cites W2010414061 @default.
• W4366998698 cites W2019370496 @default.
• W4366998698 cites W2038321648 @default.
• W4366998698 cites W2038514344 @default.
• W4366998698 cites W2044890387 @default.
• W4366998698 cites W2050666996 @default.
• W4366998698 cites W2052025479 @default.
• W4366998698 cites W2052129348 @default.
• W4366998698 cites W2058046532 @default.
• W4366998698 cites W2060497537 @default.
• W4366998698 cites W2082085086 @default.
• W4366998698 cites W2082742078 @default.
• W4366998698 cites W2089840643 @default.
• W4366998698 cites W2100647998 @default.
• W4366998698 cites W2105826831 @default.
• W4366998698 cites W2105921885 @default.
• W4366998698 cites W2116966235 @default.
• W4366998698 cites W2118660285 @default.
• W4366998698 cites W2119432914 @default.
• W4366998698 cites W2124088053 @default.
• W4366998698 cites W2125050249 @default.
• W4366998698 cites W2126213396 @default.
• W4366998698 cites W2126224104 @default.
• W4366998698 cites W2136145485 @default.
• W4366998698 cites W2145025818 @default.
• W4366998698 cites W2146393272 @default.
• W4366998698 cites W2152940329 @default.
• W4366998698 cites W2153813326 @default.
• W4366998698 cites W2153857579 @default.
• W4366998698 cites W2160863556 @default.
• W4366998698 cites W2162891965 @default.
• W4366998698 cites W2189979991 @default.
• W4366998698 cites W2208197718 @default.
• W4366998698 cites W2273050185 @default.
• W4366998698 cites W2340192219 @default.
• W4366998698 cites W2402346616 @default.
• W4366998698 cites W2562633466 @default.
• W4366998698 cites W2566614742 @default.
• W4366998698 cites W2620479743 @default.
• W4366998698 cites W2707928724 @default.
• W4366998698 cites W2738335006 @default.
• W4366998698 cites W2756276408 @default.
• W4366998698 cites W2766418257 @default.
• W4366998698 cites W2914392855 @default.
• W4366998698 cites W2918004658 @default.
• W4366998698 cites W2931013484 @default.
• W4366998698 cites W2955453891 @default.
• W4366998698 cites W2963476908 @default.
• W4366998698 cites W2987981382 @default.
• W4366998698 cites W3024238787 @default.
• W4366998698 cites W3043327830 @default.
• W4366998698 cites W3080288124 @default.
• W4366998698 cites W3081722916 @default.
• W4366998698 cites W3093887186 @default.
• W4366998698 cites W3128010551 @default.
• W4366998698 cites W3200733181 @default.
• W4366998698 cites W3206612219 @default.
• W4366998698 cites W4233041262 @default.
• W4366998698 cites W4324134915 @default.
• W4366998698 cites W829327176 @default.
• W4366998698 doi "https://doi.org/10.1101/2023.04.25.538234" @default.
• W4366998698 hasPublicationYear "2023" @default.
• W4366998698 type Work @default.
• W4366998698 citedByCount "0" @default.
• W4366998698 crossrefType "posted-content" @default.
• W4366998698 hasAuthorship W4366998698A5002797766 @default.
• W4366998698 hasAuthorship W4366998698A5009936419 @default.
• W4366998698 hasAuthorship W4366998698A5012186065 @default.
• W4366998698 hasAuthorship W4366998698A5014154314 @default.
• W4366998698 hasAuthorship W4366998698A5036767078 @default.
• W4366998698 hasAuthorship W4366998698A5049209092 @default.
• W4366998698 hasAuthorship W4366998698A5049845557 @default.
• W4366998698 hasAuthorship W4366998698A5051342198 @default.

• next