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• W4366998701 abstract "Abstract Pseudomonas aeruginosa is a leading cause of hospital-acquired infections, and the emergence of multi-drug resistant strains has prompted the search for alternative treatments such as phage therapy. In this study, we combined host range and genomic information to design a four-phage cocktail that effectively killed several clinical strains (79%, 23/29) of P. aeruginosa . We demonstrated that the cocktail, composed of three novel phages (PA_ZH1, PA_GL1, and PA_CQ9) and one previously characterized phage (PA_LZ7), was able to lyse P. aeruginosa both in planktonic cultures and in alginate microbeads (an in vivo-like biofilm model). Additionally, we showed that the phage cocktail administered intranasally or intraperitoneally effectively rescued mice from chronic lung infection with P. aeruginosa . Our work explores the potential use of phages as an alternative therapeutic agent against chronic lung infections caused by P. aeruginosa strains." @default.
• W4366998701 created "2023-04-27" @default.
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• W4366998701 date "2023-04-25" @default.
• W4366998701 modified "2023-09-23" @default.
• W4366998701 title "Efficacy of a phage cocktail preparation for chronic lung infection with<i>Pseudomonas aeruginosa</i>in mice" @default.
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• W4366998701 doi "https://doi.org/10.1101/2023.04.25.538306" @default.
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