FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4366998791> ?p ?o ?g. }

• W4366998791 abstract "Abstract Background: Malaria is a life-threatening parasitic disease typically transmitted through the bite of an infected Anopheles mosquito. There is ample evidence showing the potential of malaria infection to affect the counts of lymphocyte subpopulations in the peripheral blood, but the extent of alteration might not be consistent in all geographical locations, due to several local factors. Although Ghana is among the malaria endemic countries, there is currently no available data on the level of alterations that occur in the counts of lymphocyte subpopulations during Plasmodium falciparum malaria infection among adults. Aim: The study was to determine the immunophenotypic alterations in the level of peripheral blood lymphocytes and their subsets in adults with uncomplicated P. falciparum malaria infection and apparently healthy participants. Methods: The study was a cross-sectional comparative study conducted in two municipalities of the Volta region of Ghana. Blood samples were collected from study participants and taken through serology ( P. falciparum /Pan Rapid Diagnostic Kits), microscopy (Thick and thin blood films) and Haematological (Flow cytometric and Full blood count) analysis. Results: A total of 414 participants, comprising 214 patients with malaria (cases) and 200 apparently healthy individuals (controls) were recruited into this study. Parasite density of the malaria patients ranged from 75/µL to 84,364/µL, with a mean of 3,520/µL. It was also observed that the total lymphocytes slightly decreased in the P. falciparum infected individuals (Mean ± SD: 2.08 ± 4.93 × 10 9 /L) compared to the control group (Mean ± SD: 2.47 ± 0.80 × 10 9 /L). Again, there was a significant medium positive correlation between parasite density and haematocrit levels (r= 0.321, p < 0.001). Apart from CD45+ T-cells, more people in the control group had normal values for the lymphocyte subsets measured compared to the cases. Conclusions: From the results obtained, there was high parasite density among the malaria patients suggestive of high intensity of infection in the case group. The cases again showed considerable haematological alterations in lymphocyte sub-sets and the parasite density appeared to be strongly associated with CD4+ T-cell reduction. Also, the parasite density significantly associated with decreasing haematocrit levels." @default.
• W4366998791 created "2023-04-27" @default.
• W4366998791 creator A5006376833 @default.
• W4366998791 creator A5025291685 @default.
• W4366998791 creator A5031238173 @default.
• W4366998791 creator A5034702676 @default.
• W4366998791 creator A5052642514 @default.
• W4366998791 creator A5085309503 @default.
• W4366998791 date "2023-04-25" @default.
• W4366998791 modified "2023-09-23" @default.
• W4366998791 title "Evaluation of Immunophenotypic Alterations of Peripheral Blood Lymphocytes and their Sub-Sets in Uncomplicated P. Falciparum Infection" @default.
• W4366998791 cites W1836508298 @default.
• W4366998791 cites W1983520535 @default.
• W4366998791 cites W1989914829 @default.
• W4366998791 cites W2013114151 @default.
• W4366998791 cites W2020005421 @default.
• W4366998791 cites W2039113023 @default.
• W4366998791 cites W2042428379 @default.
• W4366998791 cites W2044186768 @default.
• W4366998791 cites W2059387693 @default.
• W4366998791 cites W2060961963 @default.
• W4366998791 cites W2073744746 @default.
• W4366998791 cites W2110243445 @default.
• W4366998791 cites W2113341236 @default.
• W4366998791 cites W2120626505 @default.
• W4366998791 cites W2123005998 @default.
• W4366998791 cites W2135802236 @default.
• W4366998791 cites W2151754909 @default.
• W4366998791 cites W2189035064 @default.
• W4366998791 cites W2331499765 @default.
• W4366998791 cites W2808210217 @default.
• W4366998791 doi "https://doi.org/10.21203/rs.3.rs-2845374/v1" @default.
• W4366998791 hasPublicationYear "2023" @default.
• W4366998791 type Work @default.
• W4366998791 citedByCount "0" @default.
• W4366998791 crossrefType "posted-content" @default.
• W4366998791 hasAuthorship W4366998791A5006376833 @default.
• W4366998791 hasAuthorship W4366998791A5025291685 @default.
• W4366998791 hasAuthorship W4366998791A5031238173 @default.
• W4366998791 hasAuthorship W4366998791A5034702676 @default.
• W4366998791 hasAuthorship W4366998791A5052642514 @default.
• W4366998791 hasAuthorship W4366998791A5085309503 @default.
• W4366998791 hasBestOaLocation W43669987911 @default.
• W4366998791 hasConcept C126322002 @default.
• W4366998791 hasConcept C159654299 @default.
• W4366998791 hasConcept C203014093 @default.
• W4366998791 hasConcept C2777761686 @default.
• W4366998791 hasConcept C2778048844 @default.
• W4366998791 hasConcept C2778371730 @default.
• W4366998791 hasConcept C45189115 @default.
• W4366998791 hasConcept C71924100 @default.
• W4366998791 hasConcept C86803240 @default.
• W4366998791 hasConceptScore W4366998791C126322002 @default.
• W4366998791 hasConceptScore W4366998791C159654299 @default.
• W4366998791 hasConceptScore W4366998791C203014093 @default.
• W4366998791 hasConceptScore W4366998791C2777761686 @default.
• W4366998791 hasConceptScore W4366998791C2778048844 @default.
• W4366998791 hasConceptScore W4366998791C2778371730 @default.
• W4366998791 hasConceptScore W4366998791C45189115 @default.
• W4366998791 hasConceptScore W4366998791C71924100 @default.
• W4366998791 hasConceptScore W4366998791C86803240 @default.
• W4366998791 hasLocation W43669987911 @default.
• W4366998791 hasOpenAccess W4366998791 @default.
• W4366998791 hasPrimaryLocation W43669987911 @default.
• W4366998791 hasRelatedWork W2096624589 @default.
• W4366998791 hasRelatedWork W2107457020 @default.
• W4366998791 hasRelatedWork W2108033231 @default.
• W4366998791 hasRelatedWork W2127166169 @default.
• W4366998791 hasRelatedWork W2144294054 @default.
• W4366998791 hasRelatedWork W2146245884 @default.
• W4366998791 hasRelatedWork W2803092263 @default.
• W4366998791 hasRelatedWork W3112431767 @default.
• W4366998791 hasRelatedWork W4205412555 @default.
• W4366998791 hasRelatedWork W69335772 @default.
• W4366998791 isParatext "false" @default.
• W4366998791 isRetracted "false" @default.
• W4366998791 workType "article" @default.