Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367011699> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4367011699 endingPage "69" @default.
- W4367011699 startingPage "55" @default.
- W4367011699 abstract "Hydrotropes are the nontoxic small organic molecules that at certain concentrations result in solubility enhancement of poorly water-soluble compounds. In this study various hydrotropes including nicotinamide, sodium acetate and trisodium citrate were used at varying ratios to observe the effect on solubility enhancement of Ebastine. Various combinations of drug-hydrotrope complexes were prepared with each above mentioned hydrotropes using solvent evaporation technique. The resultant residues were subjected to various analytical and characterization techniques for verification of complexation and solubility enhancement. These techniques included Powder X-ray diffraction studies, FTIR and UV spectroscopy. Three different formulations were prepared using various hydrotrop-drug complexes and their stability studies along with in-vitro release were carried out using simulated environment in dissolution apparatus and then later UV spectrophotometric studies were conducted.Standard curve was constructed for UV Spectroscopic analysis and the UV analysis of %age drug release from final suspension dosage form revealed 67.56%, 55.04 % and 66.76 % for the complex containing drug-nicotinamide at ratio of 3:1, drug- sodium acetate at 2:2and drug-trisodium citrate at 2:2 respectively. This release profile clearly indicated the increment in water solubility of the said insoluble drug in the prepared suspension formulated from the drug-hydrotrope complex" @default.
- W4367011699 created "2023-04-27" @default.
- W4367011699 creator A5001114156 @default.
- W4367011699 creator A5002034215 @default.
- W4367011699 creator A5026336139 @default.
- W4367011699 creator A5040097882 @default.
- W4367011699 creator A5081492315 @default.
- W4367011699 creator A5090117299 @default.
- W4367011699 date "2022-12-31" @default.
- W4367011699 modified "2023-10-07" @default.
- W4367011699 title "Effects of Hydrotropic Phenomenon on Solubility Enhancement of Ebastine; Formulation and Characterization" @default.
- W4367011699 doi "https://doi.org/10.55627/pharma.001.001.0180" @default.
- W4367011699 hasPublicationYear "2022" @default.
- W4367011699 type Work @default.
- W4367011699 citedByCount "0" @default.
- W4367011699 crossrefType "journal-article" @default.
- W4367011699 hasAuthorship W4367011699A5001114156 @default.
- W4367011699 hasAuthorship W4367011699A5002034215 @default.
- W4367011699 hasAuthorship W4367011699A5026336139 @default.
- W4367011699 hasAuthorship W4367011699A5040097882 @default.
- W4367011699 hasAuthorship W4367011699A5081492315 @default.
- W4367011699 hasAuthorship W4367011699A5090117299 @default.
- W4367011699 hasBestOaLocation W43670116991 @default.
- W4367011699 hasConcept C13965031 @default.
- W4367011699 hasConcept C155574463 @default.
- W4367011699 hasConcept C178790620 @default.
- W4367011699 hasConcept C181199279 @default.
- W4367011699 hasConcept C185592680 @default.
- W4367011699 hasConcept C2779728014 @default.
- W4367011699 hasConcept C2780400767 @default.
- W4367011699 hasConcept C2780471494 @default.
- W4367011699 hasConcept C43617362 @default.
- W4367011699 hasConcept C88380143 @default.
- W4367011699 hasConceptScore W4367011699C13965031 @default.
- W4367011699 hasConceptScore W4367011699C155574463 @default.
- W4367011699 hasConceptScore W4367011699C178790620 @default.
- W4367011699 hasConceptScore W4367011699C181199279 @default.
- W4367011699 hasConceptScore W4367011699C185592680 @default.
- W4367011699 hasConceptScore W4367011699C2779728014 @default.
- W4367011699 hasConceptScore W4367011699C2780400767 @default.
- W4367011699 hasConceptScore W4367011699C2780471494 @default.
- W4367011699 hasConceptScore W4367011699C43617362 @default.
- W4367011699 hasConceptScore W4367011699C88380143 @default.
- W4367011699 hasIssue "01" @default.
- W4367011699 hasLocation W43670116991 @default.
- W4367011699 hasOpenAccess W4367011699 @default.
- W4367011699 hasPrimaryLocation W43670116991 @default.
- W4367011699 hasRelatedWork W1996145794 @default.
- W4367011699 hasRelatedWork W2133042250 @default.
- W4367011699 hasRelatedWork W2566736651 @default.
- W4367011699 hasRelatedWork W2891665593 @default.
- W4367011699 hasRelatedWork W2899139544 @default.
- W4367011699 hasRelatedWork W2974951231 @default.
- W4367011699 hasRelatedWork W3119883245 @default.
- W4367011699 hasRelatedWork W4285013605 @default.
- W4367011699 hasRelatedWork W1993329413 @default.
- W4367011699 hasRelatedWork W2925124106 @default.
- W4367011699 hasVolume "1" @default.
- W4367011699 isParatext "false" @default.
- W4367011699 isRetracted "false" @default.
- W4367011699 workType "article" @default.