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- W4367016986 endingPage "202" @default.
- W4367016986 startingPage "202" @default.
- W4367016986 abstract "Bladder cancer ranks as the 10th most common cancer type globally, and muscle-invasive disease accounts for approximately 25% of newly diagnosed bladder cancers. Despite definitive treatment, 50% of patients with muscle-invasive bladder cancer (MIBC) develop metastasis within 2 years, leading to death. Perioperative systemic therapy is generally recommended to control local relapse or distant metastasis after surgical resection for patients with MIBC. Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is the current standard treatment to improve oncologic control and survival outcomes. Adjuvant chemotherapy is recommended for patients with pathological T3-4 or positive lymph nodes after radical cystectomy if no neoadjuvant chemotherapy was given. Nonetheless, perioperative systemic therapy is not applied widely because of its toxicity, and less than 25% of patients receive cisplatin-based neoadjuvant chemotherapy. Therefore, the development of predictive biomarkers for neoadjuvant chemotherapy efficacy and alternative effective regimens for cisplatin-ineligible patients are important. Furthermore, recently, novel anticancer agents such as immune checkpoint inhibitors and antibody-drug conjugates have proven survival benefits in the metastatic setting, thereby expanding their therapeutic applications to the perioperative setting for non-metastatic MIBC. Herein, we discuss the current status and future perspectives of perioperative systemic strategies for MIBC." @default.
- W4367016986 created "2023-04-27" @default.
- W4367016986 creator A5001951032 @default.
- W4367016986 creator A5040364316 @default.
- W4367016986 creator A5065817845 @default.
- W4367016986 creator A5066079868 @default.
- W4367016986 date "2023-01-01" @default.
- W4367016986 modified "2023-10-14" @default.
- W4367016986 title "Perioperative systemic therapy in muscle invasive bladder cancer: Current standard method, biomarkers and emerging strategies" @default.
- W4367016986 cites W1426844501 @default.
- W4367016986 cites W1506319576 @default.
- W4367016986 cites W1558385747 @default.
- W4367016986 cites W1576738591 @default.
- W4367016986 cites W1828448189 @default.
- W4367016986 cites W1893588230 @default.
- W4367016986 cites W1975918912 @default.
- W4367016986 cites W1982048464 @default.
- W4367016986 cites W1997623036 @default.
- W4367016986 cites W2010464208 @default.
- W4367016986 cites W2024783386 @default.
- W4367016986 cites W2025390735 @default.
- W4367016986 cites W2051691358 @default.
- W4367016986 cites W2051793847 @default.
- W4367016986 cites W2072065123 @default.
- W4367016986 cites W2073804272 @default.
- W4367016986 cites W2076569046 @default.
- W4367016986 cites W2101562875 @default.
- W4367016986 cites W2103257412 @default.
- W4367016986 cites W2103561213 @default.
- W4367016986 cites W2107539543 @default.
- W4367016986 cites W2113156769 @default.
- W4367016986 cites W2118503880 @default.
- W4367016986 cites W2130894756 @default.
- W4367016986 cites W2131178190 @default.
- W4367016986 cites W2137937825 @default.
- W4367016986 cites W2148132746 @default.
- W4367016986 cites W2152762320 @default.
- W4367016986 cites W2160107406 @default.
- W4367016986 cites W2160658069 @default.
- W4367016986 cites W2162130153 @default.
- W4367016986 cites W2164791945 @default.
- W4367016986 cites W2166453367 @default.
- W4367016986 cites W2288702137 @default.
- W4367016986 cites W2301685087 @default.
- W4367016986 cites W2329076941 @default.
- W4367016986 cites W2332342311 @default.
- W4367016986 cites W2417067932 @default.
- W4367016986 cites W2432541865 @default.
- W4367016986 cites W2515716590 @default.
- W4367016986 cites W2582671354 @default.
- W4367016986 cites W2588916311 @default.
- W4367016986 cites W2604441970 @default.
- W4367016986 cites W2605502219 @default.
- W4367016986 cites W2607031352 @default.
- W4367016986 cites W2737546054 @default.
- W4367016986 cites W2756190798 @default.
- W4367016986 cites W2802899563 @default.
- W4367016986 cites W2888969259 @default.
- W4367016986 cites W2893208123 @default.
- W4367016986 cites W2895579856 @default.
- W4367016986 cites W2897581535 @default.
- W4367016986 cites W2904555583 @default.
- W4367016986 cites W2910754226 @default.
- W4367016986 cites W2912226299 @default.
- W4367016986 cites W2947225585 @default.
- W4367016986 cites W2957073922 @default.
- W4367016986 cites W2958203556 @default.
- W4367016986 cites W2966500633 @default.
- W4367016986 cites W2983607390 @default.
- W4367016986 cites W2987436342 @default.
- W4367016986 cites W2989407408 @default.
- W4367016986 cites W2995899912 @default.
- W4367016986 cites W3001752792 @default.
- W4367016986 cites W3007839305 @default.
- W4367016986 cites W3008870350 @default.
- W4367016986 cites W3016992845 @default.
- W4367016986 cites W3026086919 @default.
- W4367016986 cites W3030130251 @default.
- W4367016986 cites W3032403184 @default.
- W4367016986 cites W3035230667 @default.
- W4367016986 cites W3047618013 @default.
- W4367016986 cites W3048767892 @default.
- W4367016986 cites W3081754656 @default.
- W4367016986 cites W3088018720 @default.
- W4367016986 cites W3092138236 @default.
- W4367016986 cites W3118434887 @default.
- W4367016986 cites W3123935228 @default.
- W4367016986 cites W3126799484 @default.
- W4367016986 cites W3127912627 @default.
- W4367016986 cites W3128646645 @default.
- W4367016986 cites W3135321607 @default.
- W4367016986 cites W3138703636 @default.
- W4367016986 cites W3144473405 @default.
- W4367016986 cites W3154268497 @default.
- W4367016986 cites W3157692800 @default.
- W4367016986 cites W3163995648 @default.
- W4367016986 cites W3164582383 @default.
- W4367016986 cites W3191658268 @default.