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- W4367017464 abstract "A two-step process inserts a carbon atom into the aromatic nitrogen–containing rings of pyrroles and indoles, expanding them and forming pyridines and quinolines, respectively. The technique broadens the tool kit for adding functional groups to pyridine or quinoline scaffolds, which are found in countless drugs and drug candidates ( J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c06287 ). Researchers led by Mark D. Levin of the University of Chicago updated a reaction first described in 1881 that produces six-membered pyridine rings by inserting a carbene into a five-membered pyrrole ring. Chemists typically generate the carbene by adding chloroform or similar trihalogenated compounds to the reaction, which limits the substituents on the resulting pyridine ring to halogens. Levin’s team instead replaced the chloroform reactants with chlorodiazirines, which break down to a carbynyl cation and nitrogen gas. Like a carbene, the carbynyl cation can add to pyrroles or indoles, expanding them into pyridines" @default.
- W4367017464 created "2023-04-27" @default.
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- W4367017464 date "2021-08-23" @default.
- W4367017464 modified "2023-09-23" @default.
- W4367017464 title "Reaction expands nitrogen-containing rings" @default.
- W4367017464 doi "https://doi.org/10.1021/cen-09930-scicon9" @default.
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