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- W4367017550 abstract "Researchers have found a new molecular role for MeCP2, the protein that doesn’t work correctly in people with Rett syndrome. The findings could suggest new ways to treat the neurodevelopmental condition, the scientists say. Rett syndrome is a genetic condition that mainly affects girls, and usually becomes apparent in children 6–18 months old. Those children with the syndrome regress developmentally and lose motor control and the ability to speak. In 1999, Huda Zoghbi at the Baylor College of Medicine and colleagues determined that the disorder was caused by mutations in the gene coding for the protein MeCP2. Ali Hamiche at the Institute of Genetics and of Molecular and Cellular Biology in Strasbourg and his group found the new role for MeCP2 while investigating methylated and hydroxymethylated cytosine and adenosine repeats in DNA (CACACACA, and so on). The group was looking for proteins that bind or interact with these genetic elements" @default.
- W4367017550 created "2023-04-27" @default.
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- W4367017550 date "2021-06-28" @default.
- W4367017550 modified "2023-09-26" @default.
- W4367017550 title "Possible molecular mechanism of Rett syndrome identified" @default.
- W4367017550 doi "https://doi.org/10.1021/cen-09924-scicon1" @default.
- W4367017550 hasPublicationYear "2021" @default.
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