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- W4367017551 abstract "The US Food and Drug Administration approved new drugs at a substantial clip last year, even as the agency continued to maneuver through other urgent business related to the continuing COVID-19 pandemic, including evaluating tests, vaccines for children, and antiviral compounds . The agency approved 50 new molecular entities in 2021, just three fewer than the number it cleared in 2020 . Among the new approvals were 31 small molecules, accounting for 62% of the new drug pipeline. Notable new small-molecule drugs include a long-acting HIV therapy , a novel antifungal , and an inhibitor of KRAS G12C—a cancer target that drugmakers have been pursuing for years . Larger molecular entities also had a strong year, with several antibodies and protein therapeutics getting the FDA’s nod. The agency also approved two anticancer antibody-drug conjugates , a cholesterol-lowering drug that works through RNA interference, and a controversial antibody treatment for Alzheimer’s" @default.
- W4367017551 created "2023-04-27" @default.
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- W4367017551 date "2022-01-17" @default.
- W4367017551 modified "2023-09-23" @default.
- W4367017551 title "New drug approvals held steady in 2021" @default.
- W4367017551 doi "https://doi.org/10.1021/cen-10002-feature1" @default.
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