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- W4367017680 abstract "Combining microscopy methods achieves superresolution imaging without fluorescent labels. Lu Wei and coworkers at the California Institute of Technology have combined stimulated Raman scattering (SRS) with expansion microscopy ( Nat. Commun. 2021, DOI: 10.1038/s41467-021-23951-x ). They call the approach vibrational imaging of swelled tissues and analysis (VISTA). It combines the molecular specificity of SRS with the spatial resolution of expansion microscopy. In VISTA, the researchers embed biological tissue samples in a polymer hydrogel, expand the hydrogel in water, and image the sample using CH 3 vibrations in proteins. When they followed conventional expansion microscopy protocols, which involves chemical cross-linking and protein digestion, a large fraction of the protein in the sample was lost. Instead of digesting the proteins, they denatured them, which preserved the Raman signal. The method achieved spatial resolution of 78 nm. The researchers used VISTA to image various biological samples, including cells undergoing division, zebrafish embryonic retinas," @default.
- W4367017680 created "2023-04-27" @default.
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- W4367017680 date "2021-06-28" @default.
- W4367017680 modified "2023-09-23" @default.
- W4367017680 title "Microscopy method achieves superresolution without labels" @default.
- W4367017680 doi "https://doi.org/10.1021/cen-09924-scicon2" @default.
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