FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367018575> ?p ?o ?g. }

• W4367018575 abstract "Introduction Cervical artery dissection (CAD) is a common cause of stroke in the young and carries a high risk of early recurrence. Traditionally, the treatment consisted of antithrombotic therapy for at least 3months. There is mixed evidence on whether antiplatelet therapy is as effective as anticoagulation in such patients, and prior studies are limited by small sample size due to the low incidence of CAD, as well as not investigating more modern treatment regimens such as direct oral anticoagulants (DOAC) and increasingly utilized dual antiplatelet therapy (DAPT) strategies. The Anti‐Thrombotic Therapy for Stroke Prevention in Cervical Artery Dissection (STOP‐CAD)studyaims to compare the safety and effectiveness of different antithrombotic regimens in patients with acute spontaneous CAD. We hypothesize thatdual antiplatelet therapy (DAPT) followed by a single agent has comparable safety and efficacy to anticoagulation in patients with CAD. Methods STOP‐CAD is amulticenter cross‐sectional international retrospective study.All patientsaged 18–89 years with imaging‐confirmed diagnosis of non‐traumatic CAD treated with antithrombotic therapy will be included. Imaging diagnosis will be adjudicated by the principal investigator from each individual site. Patients present with CAD in the setting of major trauma will be excluded. Baseline demographics, clinical, laboratory and imaging information will becollected. Outcomes include subsequent ischemic stroke, symptomatic intracranial hemorrhage, major hemorrhage, recanalization status, and death within 180 days. We will compare the clinical outcomes between antiplatelet and anticoagulation groups using Cox regression models, and the radiographic outcomes across the two groups using logistic regression models. We will use inverse probability of treatment weighting and adjust for prespecified variable as well as variables that differ between the two groups. We will use propensity score matching with and without replacement for the outcome analyses. Results Currently at least 40 international sites have agreed to contribute to this study. Multiple sites have already started the data input process, and more have started the IRB process. We expect the data collection to be completed by the end of December 2022, and the data analysis to be completed by the end of June 2023. Conclusions STOP‐CAD will provide real world data comparing the safety and efficacy of DAPT vs. anticoagulation in patients with cervical artery dissection. In addition, multiple sub‐studies will be conducted using the same database on topics such as efficacy of interventional treatment and predictors of poor outcomes." @default.
• W4367018575 created "2023-04-27" @default.
• W4367018575 creator A5010879728 @default.
• W4367018575 creator A5023431700 @default.
• W4367018575 creator A5035289770 @default.
• W4367018575 date "2023-03-01" @default.
• W4367018575 modified "2023-10-14" @default.
• W4367018575 title "Abstract Number ‐ 256: Anti‐Thrombotic Therapy for Stroke Prevention in Cervical Artery Dissection: protocol of a multicenter international study" @default.
• W4367018575 doi "https://doi.org/10.1161/svin.03.suppl_1.256" @default.
• W4367018575 hasPublicationYear "2023" @default.
• W4367018575 type Work @default.
• W4367018575 citedByCount "0" @default.
• W4367018575 crossrefType "journal-article" @default.
• W4367018575 hasAuthorship W4367018575A5010879728 @default.
• W4367018575 hasAuthorship W4367018575A5023431700 @default.
• W4367018575 hasAuthorship W4367018575A5035289770 @default.
• W4367018575 hasBestOaLocation W43670185751 @default.
• W4367018575 hasConcept C126322002 @default.
• W4367018575 hasConcept C127413603 @default.
• W4367018575 hasConcept C141071460 @default.
• W4367018575 hasConcept C2775862295 @default.
• W4367018575 hasConcept C2776629196 @default.
• W4367018575 hasConcept C2777015399 @default.
• W4367018575 hasConcept C2777094939 @default.
• W4367018575 hasConcept C2777736543 @default.
• W4367018575 hasConcept C2780645631 @default.
• W4367018575 hasConcept C2910348082 @default.
• W4367018575 hasConcept C71924100 @default.
• W4367018575 hasConcept C78519656 @default.
• W4367018575 hasConceptScore W4367018575C126322002 @default.
• W4367018575 hasConceptScore W4367018575C127413603 @default.
• W4367018575 hasConceptScore W4367018575C141071460 @default.
• W4367018575 hasConceptScore W4367018575C2775862295 @default.
• W4367018575 hasConceptScore W4367018575C2776629196 @default.
• W4367018575 hasConceptScore W4367018575C2777015399 @default.
• W4367018575 hasConceptScore W4367018575C2777094939 @default.
• W4367018575 hasConceptScore W4367018575C2777736543 @default.
• W4367018575 hasConceptScore W4367018575C2780645631 @default.
• W4367018575 hasConceptScore W4367018575C2910348082 @default.
• W4367018575 hasConceptScore W4367018575C71924100 @default.
• W4367018575 hasConceptScore W4367018575C78519656 @default.
• W4367018575 hasIssue "S1" @default.
• W4367018575 hasLocation W43670185751 @default.
• W4367018575 hasOpenAccess W4367018575 @default.
• W4367018575 hasPrimaryLocation W43670185751 @default.
• W4367018575 hasRelatedWork W1829587473 @default.
• W4367018575 hasRelatedWork W1965964445 @default.
• W4367018575 hasRelatedWork W2039293498 @default.
• W4367018575 hasRelatedWork W2062304047 @default.
• W4367018575 hasRelatedWork W2082252701 @default.
• W4367018575 hasRelatedWork W2130295322 @default.
• W4367018575 hasRelatedWork W2320433965 @default.
• W4367018575 hasRelatedWork W2396404771 @default.
• W4367018575 hasRelatedWork W2603982364 @default.
• W4367018575 hasRelatedWork W4237142930 @default.
• W4367018575 hasVolume "3" @default.
• W4367018575 isParatext "false" @default.
• W4367018575 isRetracted "false" @default.
• W4367018575 workType "article" @default.