Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367018628> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W4367018628 abstract "Introduction Stroke is a major cause of adult disability and death worldwide. The subsequent development of neuroinflammation dramatically increases the risks associated with stroke. Microglia are key immune cells that respond to microenvironmental changes during ischemic stroke. The M1 subtype of microglia is a proinflammatory phenotype that promotes neuroinflammation‐induced secondary brain damage. However, the mechanism of stroke‐induced microglia M1 polarization and the interaction between microglia and neuron within the stroke area remain unclear. Methods Using a murine middle cerebral artery occlusion (MCAO) model and chemogenetics, we manipulated neuronal activity to study whether neuronal activity modulates microglia polarization and whether manipulating this neuron‐immune axis prevents neuroinflammation after stroke. Results Our findings demonstrate that the abnormal neuronal activation and depolarization induced by brain ischemia drive microglial proinflammatory M1 polarization through neuron‐derived exosome secretion through activating the NF‐kB pathway. Inhibiting the ischemia‐induced neuronal activity reversed this microglial M1 polarization and decreased the pro‐inflammatory cytokines in the mouse brain. In addition, midazolam administration inhibited the abnormal neuronal activity and the microglia pro‐inflammatory polarization. Conclusions Together, these findings indicate that inhibiting abnormal neuronal activation triggered by ischemia prevents the microglia‐induced neuroinflammation that could protect the brain from secondary brain damage." @default.
- W4367018628 created "2023-04-27" @default.
- W4367018628 creator A5076044387 @default.
- W4367018628 date "2023-03-01" @default.
- W4367018628 modified "2023-10-18" @default.
- W4367018628 title "Abstract Number ‐ 62: Inhibiting neuron‐immune axis in acute stroke reverses microglia‐induced neuroinflammation" @default.
- W4367018628 doi "https://doi.org/10.1161/svin.03.suppl_1.062" @default.
- W4367018628 hasPublicationYear "2023" @default.
- W4367018628 type Work @default.
- W4367018628 citedByCount "0" @default.
- W4367018628 crossrefType "journal-article" @default.
- W4367018628 hasAuthorship W4367018628A5076044387 @default.
- W4367018628 hasBestOaLocation W43670186281 @default.
- W4367018628 hasConcept C127413603 @default.
- W4367018628 hasConcept C164027704 @default.
- W4367018628 hasConcept C169760540 @default.
- W4367018628 hasConcept C203014093 @default.
- W4367018628 hasConcept C2776914184 @default.
- W4367018628 hasConcept C2778794669 @default.
- W4367018628 hasConcept C2779830541 @default.
- W4367018628 hasConcept C2780645631 @default.
- W4367018628 hasConcept C71924100 @default.
- W4367018628 hasConcept C78519656 @default.
- W4367018628 hasConcept C86803240 @default.
- W4367018628 hasConcept C87753298 @default.
- W4367018628 hasConcept C8891405 @default.
- W4367018628 hasConceptScore W4367018628C127413603 @default.
- W4367018628 hasConceptScore W4367018628C164027704 @default.
- W4367018628 hasConceptScore W4367018628C169760540 @default.
- W4367018628 hasConceptScore W4367018628C203014093 @default.
- W4367018628 hasConceptScore W4367018628C2776914184 @default.
- W4367018628 hasConceptScore W4367018628C2778794669 @default.
- W4367018628 hasConceptScore W4367018628C2779830541 @default.
- W4367018628 hasConceptScore W4367018628C2780645631 @default.
- W4367018628 hasConceptScore W4367018628C71924100 @default.
- W4367018628 hasConceptScore W4367018628C78519656 @default.
- W4367018628 hasConceptScore W4367018628C86803240 @default.
- W4367018628 hasConceptScore W4367018628C87753298 @default.
- W4367018628 hasConceptScore W4367018628C8891405 @default.
- W4367018628 hasIssue "S1" @default.
- W4367018628 hasLocation W43670186281 @default.
- W4367018628 hasOpenAccess W4367018628 @default.
- W4367018628 hasPrimaryLocation W43670186281 @default.
- W4367018628 hasRelatedWork W129295582 @default.
- W4367018628 hasRelatedWork W2003556082 @default.
- W4367018628 hasRelatedWork W2016648239 @default.
- W4367018628 hasRelatedWork W2232520593 @default.
- W4367018628 hasRelatedWork W2735949591 @default.
- W4367018628 hasRelatedWork W2992532952 @default.
- W4367018628 hasRelatedWork W3212699394 @default.
- W4367018628 hasRelatedWork W3217065140 @default.
- W4367018628 hasRelatedWork W4312178155 @default.
- W4367018628 hasRelatedWork W4323364905 @default.
- W4367018628 hasVolume "3" @default.
- W4367018628 isParatext "false" @default.
- W4367018628 isRetracted "false" @default.
- W4367018628 workType "article" @default.