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- W4367024379 abstract "Stablix Therapeutics has launched with $63 million in funding to explore drugs that can rescue proteins otherwise destined for the cellular waste bin. The New York City–based biotech firm turns on its head the concept of targeted protein degradation , in which researchers design drugs that force bad-behaving proteins into the proteasome, the cell’s trash can. Typically, one end of those heterobifunctional small molecules binds to a protein of interest. The other binds to an E3 ligase, an enzyme that kicks off a chain of events that ends in the addition of a ubiquitin to the protein. The ubiquitin tags the protein to be broken down in the proteasome. Stablix wants to design molecules that pluck off that tag, restoring function to proteins otherwise destined for the trash. One end will bind to a protein of interest, while the other will tether to a deubiquitinase (DUB). About a hundred DUBs" @default.
- W4367024379 created "2023-04-27" @default.
- W4367024379 creator A5033782239 @default.
- W4367024379 date "2021-06-07" @default.
- W4367024379 modified "2023-09-28" @default.
- W4367024379 title "Stablix debuts to stabilize protein function" @default.
- W4367024379 doi "https://doi.org/10.1021/cen-09921-buscon4" @default.
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