Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367042676> ?p ?o ?g. }
- W4367042676 endingPage "3435" @default.
- W4367042676 startingPage "3429" @default.
- W4367042676 abstract "An increased risk of chorioamnionitis in people receiving tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine during pregnancy has been reported. The importance of this association is unclear as additional study has not demonstrated increased adverse infant outcomes associated with Tdap vaccination in pregnancy.We conducted a retrospective observational cohort study of pregnant people ages 15-49 years with singleton pregnancies ending in live birth who were members of 8 Vaccine Safety Datalink (VSD) sites during October 2016-September 2018. We used a time-dependent covariate Cox model with stabilized inverse probability weights applied to evaluate associations between Tdap vaccination during pregnancy and chorioamnionitis and preterm birth outcomes. We used Poisson regression with robust variance with stabilized inverse probability weights applied to evaluate the association of Tdap vaccination with adverse infant outcomes. We performed medical record reviews on a random sample of patients with ICD-10-CM-diagnosed chorioamnionitis to determine positive predictive values (PPV) of coded chorioamnionitisfor probable clinical chorioamnionitis, possible clinical chorioamnionitis, or histologic chorioamnionitis.We included 118,211 pregnant people; 103,258 (87%) received Tdap vaccine during pregnancy; 8098 (7%) were diagnosed with chorioamnionitis. The adjusted hazard ratio for chorioamnionitis in the Tdap vaccine-exposed group compared to unexposed was 0.96 (95% CI 0.90-1.03). There was no association between Tdap vaccine and preterm birth or adverse infant outcomes associated with chorioamnionitis. Chart reviews were performed for 528 pregnant people with chorioamnionitis. The PPV for clinical (probable or possible clinical chorioamnionitis) was 48% and 59% for histologic chorioamnionitis. The PPV for the combined outcome of clinical or histologic chorioamnionitis was 81%.Tdap vaccine exposure during pregnancy was not associated with chorioamnionitis, preterm birth, or adverse infant outcomes. ICD-10 codes for chorioamnionitis lack specificity for clinical chorioamnionitis and should be a recognized limitation when interpreting results." @default.
- W4367042676 created "2023-04-27" @default.
- W4367042676 creator A5000635762 @default.
- W4367042676 creator A5006755486 @default.
- W4367042676 creator A5011431528 @default.
- W4367042676 creator A5020891630 @default.
- W4367042676 creator A5030551838 @default.
- W4367042676 creator A5034478332 @default.
- W4367042676 creator A5038160777 @default.
- W4367042676 creator A5043890496 @default.
- W4367042676 creator A5053590091 @default.
- W4367042676 creator A5059710500 @default.
- W4367042676 creator A5071176605 @default.
- W4367042676 creator A5087679354 @default.
- W4367042676 creator A5090765456 @default.
- W4367042676 date "2023-05-01" @default.
- W4367042676 modified "2023-10-14" @default.
- W4367042676 title "Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes" @default.
- W4367042676 cites W1994673004 @default.
- W4367042676 cites W1997057722 @default.
- W4367042676 cites W2003445750 @default.
- W4367042676 cites W2009582968 @default.
- W4367042676 cites W2010608085 @default.
- W4367042676 cites W2031618098 @default.
- W4367042676 cites W2033901501 @default.
- W4367042676 cites W2047311368 @default.
- W4367042676 cites W2066477655 @default.
- W4367042676 cites W2073808955 @default.
- W4367042676 cites W2078082208 @default.
- W4367042676 cites W2088154311 @default.
- W4367042676 cites W2092077411 @default.
- W4367042676 cites W2116249372 @default.
- W4367042676 cites W2166992661 @default.
- W4367042676 cites W2304812563 @default.
- W4367042676 cites W2409275834 @default.
- W4367042676 cites W2497107473 @default.
- W4367042676 cites W2546937923 @default.
- W4367042676 cites W2619343341 @default.
- W4367042676 cites W2731631449 @default.
- W4367042676 cites W2766006906 @default.
- W4367042676 cites W2801445501 @default.
- W4367042676 cites W2915065822 @default.
- W4367042676 cites W2945764563 @default.
- W4367042676 cites W2966062113 @default.
- W4367042676 cites W2990504287 @default.
- W4367042676 cites W3006399024 @default.
- W4367042676 cites W3167507776 @default.
- W4367042676 cites W3186245845 @default.
- W4367042676 cites W4205144101 @default.
- W4367042676 cites W4206784734 @default.
- W4367042676 cites W4221082915 @default.
- W4367042676 cites W4238580821 @default.
- W4367042676 cites W4300867520 @default.
- W4367042676 cites W3022943829 @default.
- W4367042676 doi "https://doi.org/10.1016/j.vaccine.2023.04.043" @default.
- W4367042676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37117057" @default.
- W4367042676 hasPublicationYear "2023" @default.
- W4367042676 type Work @default.
- W4367042676 citedByCount "2" @default.
- W4367042676 countsByYear W43670426762023 @default.
- W4367042676 crossrefType "journal-article" @default.
- W4367042676 hasAuthorship W4367042676A5000635762 @default.
- W4367042676 hasAuthorship W4367042676A5006755486 @default.
- W4367042676 hasAuthorship W4367042676A5011431528 @default.
- W4367042676 hasAuthorship W4367042676A5020891630 @default.
- W4367042676 hasAuthorship W4367042676A5030551838 @default.
- W4367042676 hasAuthorship W4367042676A5034478332 @default.
- W4367042676 hasAuthorship W4367042676A5038160777 @default.
- W4367042676 hasAuthorship W4367042676A5043890496 @default.
- W4367042676 hasAuthorship W4367042676A5053590091 @default.
- W4367042676 hasAuthorship W4367042676A5059710500 @default.
- W4367042676 hasAuthorship W4367042676A5071176605 @default.
- W4367042676 hasAuthorship W4367042676A5087679354 @default.
- W4367042676 hasAuthorship W4367042676A5090765456 @default.
- W4367042676 hasBestOaLocation W43670426761 @default.
- W4367042676 hasConcept C126322002 @default.
- W4367042676 hasConcept C131872663 @default.
- W4367042676 hasConcept C167135981 @default.
- W4367042676 hasConcept C187212893 @default.
- W4367042676 hasConcept C201903717 @default.
- W4367042676 hasConcept C203014093 @default.
- W4367042676 hasConcept C22070199 @default.
- W4367042676 hasConcept C2777102558 @default.
- W4367042676 hasConcept C2777629866 @default.
- W4367042676 hasConcept C2778376644 @default.
- W4367042676 hasConcept C2779234561 @default.
- W4367042676 hasConcept C54355233 @default.
- W4367042676 hasConcept C71924100 @default.
- W4367042676 hasConcept C72563966 @default.
- W4367042676 hasConcept C86803240 @default.
- W4367042676 hasConceptScore W4367042676C126322002 @default.
- W4367042676 hasConceptScore W4367042676C131872663 @default.
- W4367042676 hasConceptScore W4367042676C167135981 @default.
- W4367042676 hasConceptScore W4367042676C187212893 @default.
- W4367042676 hasConceptScore W4367042676C201903717 @default.
- W4367042676 hasConceptScore W4367042676C203014093 @default.
- W4367042676 hasConceptScore W4367042676C22070199 @default.
- W4367042676 hasConceptScore W4367042676C2777102558 @default.