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- W4367048689 abstract "Despite improvements in treatment and diagnostics over the last two decades, invasive aspergillosis (IA) remains a devastating fungal disease. The number of immunocompromised patients and hence vulnerable hosts increases, which is paralleled by the emergence of a rise in IA cases. Increased frequencies of azole-resistant strains are reported from six continents, presenting a new challenge for the therapeutic management. Treatment options for IA currently consist of three classes of antifungals (azoles, polyenes, echinocandins) with distinctive advantages and shortcomings. Especially in settings of difficult to treat IA, comprising drug tolerance/resistance, limiting drug-drug interactions, and/or severe underlying organ dysfunction, novel approaches are urgently needed. Promising new drugs for the treatment of IA are in late-stage clinical development, including olorofim (a dihydroorotate dehydrogenase inhibitor), fosmanogepix (a Gwt1 enzyme inhibitor), ibrexafungerp (a triterpenoid), opelconazole (an azole optimized for inhalation) and rezafungin (an echinocandin with long half-life time). Further, new insights in the pathophysiology of IA yielding immunotherapy as a potential add-on therapy. Current investigations show encouraging results, so far mostly in preclinical settings. In this review we discuss current treatment strategies, give an outlook on possible new pharmaceutical therapeutic options, and, lastly, provide an overview of the ongoing research in immunotherapy for IA." @default.
- W4367048689 created "2023-04-27" @default.
- W4367048689 creator A5031263964 @default.
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- W4367048689 creator A5075997351 @default.
- W4367048689 creator A5080736786 @default.
- W4367048689 date "2023-04-26" @default.
- W4367048689 modified "2023-10-17" @default.
- W4367048689 title "Treatment of Invasive Aspergillosis: How It’s Going, Where It’s Heading" @default.
- W4367048689 cites W105031452 @default.
- W4367048689 cites W1490753351 @default.
- W4367048689 cites W1572283658 @default.
- W4367048689 cites W1593763878 @default.
- W4367048689 cites W1621851081 @default.
- W4367048689 cites W1637489882 @default.
- W4367048689 cites W1896572253 @default.
- W4367048689 cites W1939669701 @default.
- W4367048689 cites W1964720826 @default.
- W4367048689 cites W1978576737 @default.
- W4367048689 cites W1989268671 @default.
- W4367048689 cites W1991149656 @default.
- W4367048689 cites W2005803431 @default.
- W4367048689 cites W2008594793 @default.
- W4367048689 cites W2009001679 @default.
- W4367048689 cites W2019074697 @default.
- W4367048689 cites W2020036784 @default.
- W4367048689 cites W2025781394 @default.
- W4367048689 cites W2030566485 @default.
- W4367048689 cites W2030664045 @default.
- W4367048689 cites W2037676380 @default.
- W4367048689 cites W2043474036 @default.
- W4367048689 cites W2048092714 @default.
- W4367048689 cites W2055689496 @default.
- W4367048689 cites W2069914325 @default.
- W4367048689 cites W2076838229 @default.
- W4367048689 cites W2080468965 @default.
- W4367048689 cites W2082695689 @default.
- W4367048689 cites W2087231890 @default.
- W4367048689 cites W2087796927 @default.
- W4367048689 cites W2096734724 @default.
- W4367048689 cites W2107002415 @default.
- W4367048689 cites W2108675611 @default.
- W4367048689 cites W2114168745 @default.
- W4367048689 cites W2121779980 @default.
- W4367048689 cites W2123659189 @default.
- W4367048689 cites W2130529244 @default.
- W4367048689 cites W2130592554 @default.
- W4367048689 cites W2132582661 @default.
- W4367048689 cites W2137916005 @default.
- W4367048689 cites W2144677985 @default.
- W4367048689 cites W2150824761 @default.
- W4367048689 cites W2152568591 @default.
- W4367048689 cites W2155935143 @default.
- W4367048689 cites W2159713325 @default.
- W4367048689 cites W2162553756 @default.
- W4367048689 cites W2163206122 @default.
- W4367048689 cites W2163773890 @default.
- W4367048689 cites W2166822160 @default.
- W4367048689 cites W2166875045 @default.
- W4367048689 cites W2170566395 @default.
- W4367048689 cites W2189861011 @default.
- W4367048689 cites W2261554194 @default.
- W4367048689 cites W2287376080 @default.
- W4367048689 cites W2297563958 @default.
- W4367048689 cites W2299734421 @default.
- W4367048689 cites W2401975482 @default.
- W4367048689 cites W2409153255 @default.
- W4367048689 cites W2470291098 @default.
- W4367048689 cites W2483473788 @default.
- W4367048689 cites W2507731994 @default.
- W4367048689 cites W2550985426 @default.
- W4367048689 cites W2559853894 @default.
- W4367048689 cites W2560804544 @default.
- W4367048689 cites W2563079954 @default.
- W4367048689 cites W2767274740 @default.
- W4367048689 cites W2789752885 @default.
- W4367048689 cites W2792314560 @default.
- W4367048689 cites W2793884909 @default.
- W4367048689 cites W2799771305 @default.
- W4367048689 cites W2801469916 @default.
- W4367048689 cites W2802265538 @default.
- W4367048689 cites W2802474948 @default.
- W4367048689 cites W2806377687 @default.
- W4367048689 cites W2885501791 @default.
- W4367048689 cites W2886093859 @default.
- W4367048689 cites W2886222856 @default.
- W4367048689 cites W2903750794 @default.
- W4367048689 cites W2905667771 @default.
- W4367048689 cites W2913604562 @default.
- W4367048689 cites W2920115754 @default.
- W4367048689 cites W2923672192 @default.
- W4367048689 cites W2924814601 @default.
- W4367048689 cites W2944877455 @default.
- W4367048689 cites W2946571129 @default.
- W4367048689 cites W2953587523 @default.
- W4367048689 cites W2954710919 @default.
- W4367048689 cites W2961383660 @default.