FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367050307> ?p ?o ?g. }

• W4367050307 abstract "Mechanically activated (MA) ion channels confer somatosensory neurons with the ability to sense a wide range of mechanical stimuli. MA ion channel activity in somatosensory neurons is best described by the electrophysiological recordings of MA currents in cultured dorsal root ganglion (DRG) neurons. Biophysical and pharmacological characterization of DRG MA currents has guided the field in screening/confirming channel candidates that induce the currents and facilitate the mechanosensory response. But studies on DRG MA currents have relied mostly on whole-cell macroscopic current properties obtained by membrane indentation, and little is known about the underlying MA ion channels at the single-channel level. Here, by acquiring indentation-induced macroscopic currents as well as stretch-activated single-channel currents from the same cell, we associate macroscopic current properties with single-channel conductance. This analysis reveals the nature of the MA channel responsible for the ensemble response. We observe four different conductances in DRG neurons with no association with a specific type of macroscopic current. Applying this methodology to a Piezo2 expressing DRG neuronal subpopulation allows us to identify PIEZO2-dependent stretch-activated currents and conductance. Moreover, we demonstrate that upon Piezo2 deletion, the remaining macroscopic responses are predominantly mediated by three different single-channel conductances. Collectively, our data predict that at least two other MA ion channels exist in DRG neurons that remain to be discovered." @default.
• W4367050307 created "2023-04-27" @default.
• W4367050307 creator A5020755193 @default.
• W4367050307 date "2023-04-26" @default.
• W4367050307 modified "2023-09-30" @default.
• W4367050307 title "Deciphering mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons" @default.
• W4367050307 cites W1940488155 @default.
• W4367050307 cites W1991828413 @default.
• W4367050307 cites W1999720993 @default.
• W4367050307 cites W2035330601 @default.
• W4367050307 cites W2047012091 @default.
• W4367050307 cites W2066905281 @default.
• W4367050307 cites W2083824794 @default.
• W4367050307 cites W2092614177 @default.
• W4367050307 cites W2107462996 @default.
• W4367050307 cites W2107634021 @default.
• W4367050307 cites W2108039931 @default.
• W4367050307 cites W2111823524 @default.
• W4367050307 cites W2128490730 @default.
• W4367050307 cites W2129653669 @default.
• W4367050307 cites W2166599924 @default.
• W4367050307 cites W2184968222 @default.
• W4367050307 cites W2193068214 @default.
• W4367050307 cites W2256087259 @default.
• W4367050307 cites W2260991120 @default.
• W4367050307 cites W2286255985 @default.
• W4367050307 cites W2422180038 @default.
• W4367050307 cites W2525001998 @default.
• W4367050307 cites W2605554157 @default.
• W4367050307 cites W2773700017 @default.
• W4367050307 cites W2802857141 @default.
• W4367050307 cites W2896293926 @default.
• W4367050307 cites W2896504526 @default.
• W4367050307 cites W2950029213 @default.
• W4367050307 cites W2950162000 @default.
• W4367050307 cites W2950904949 @default.
• W4367050307 cites W2954202195 @default.
• W4367050307 cites W2999978880 @default.
• W4367050307 cites W3006898855 @default.
• W4367050307 cites W3009937536 @default.
• W4367050307 cites W3093018209 @default.
• W4367050307 cites W3102171959 @default.
• W4367050307 cites W3122474387 @default.
• W4367050307 cites W3175140089 @default.
• W4367050307 cites W3191221784 @default.
• W4367050307 cites W3195054032 @default.
• W4367050307 cites W3208512229 @default.
• W4367050307 cites W4211264697 @default.
• W4367050307 cites W4220903771 @default.
• W4367050307 cites W4283272302 @default.
• W4367050307 cites W4308294180 @default.
• W4367050307 doi "https://doi.org/10.1085/jgp.202213099" @default.
• W4367050307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37102984" @default.
• W4367050307 hasPublicationYear "2023" @default.
• W4367050307 type Work @default.
• W4367050307 citedByCount "1" @default.
• W4367050307 countsByYear W43670503072023 @default.
• W4367050307 crossrefType "journal-article" @default.
• W4367050307 hasAuthorship W4367050307A5020755193 @default.
• W4367050307 hasConcept C121332964 @default.
• W4367050307 hasConcept C121932024 @default.
• W4367050307 hasConcept C12554922 @default.
• W4367050307 hasConcept C147944092 @default.
• W4367050307 hasConcept C169760540 @default.
• W4367050307 hasConcept C170493617 @default.
• W4367050307 hasConcept C172497186 @default.
• W4367050307 hasConcept C181911157 @default.
• W4367050307 hasConcept C185263204 @default.
• W4367050307 hasConcept C185592680 @default.
• W4367050307 hasConcept C26873012 @default.
• W4367050307 hasConcept C2776281502 @default.
• W4367050307 hasConcept C50254741 @default.
• W4367050307 hasConcept C55493867 @default.
• W4367050307 hasConcept C86803240 @default.
• W4367050307 hasConcept C94487597 @default.
• W4367050307 hasConceptScore W4367050307C121332964 @default.
• W4367050307 hasConceptScore W4367050307C121932024 @default.
• W4367050307 hasConceptScore W4367050307C12554922 @default.
• W4367050307 hasConceptScore W4367050307C147944092 @default.
• W4367050307 hasConceptScore W4367050307C169760540 @default.
• W4367050307 hasConceptScore W4367050307C170493617 @default.
• W4367050307 hasConceptScore W4367050307C172497186 @default.
• W4367050307 hasConceptScore W4367050307C181911157 @default.
• W4367050307 hasConceptScore W4367050307C185263204 @default.
• W4367050307 hasConceptScore W4367050307C185592680 @default.
• W4367050307 hasConceptScore W4367050307C26873012 @default.
• W4367050307 hasConceptScore W4367050307C2776281502 @default.
• W4367050307 hasConceptScore W4367050307C50254741 @default.
• W4367050307 hasConceptScore W4367050307C55493867 @default.
• W4367050307 hasConceptScore W4367050307C86803240 @default.
• W4367050307 hasConceptScore W4367050307C94487597 @default.
• W4367050307 hasIssue "6" @default.
• W4367050307 hasLocation W43670503071 @default.
• W4367050307 hasLocation W43670503072 @default.
• W4367050307 hasOpenAccess W4367050307 @default.
• W4367050307 hasPrimaryLocation W43670503071 @default.
• W4367050307 hasRelatedWork W111279135 @default.
• W4367050307 hasRelatedWork W1971707504 @default.
• W4367050307 hasRelatedWork W1992055301 @default.
• W4367050307 hasRelatedWork W2016910868 @default.

• next