Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367051857> ?p ?o ?g. }
- W4367051857 endingPage "3981" @default.
- W4367051857 startingPage "3964" @default.
- W4367051857 abstract "Abstract Doxorubicin (DOX), an effective chemotherapeutic drug, has been used to treat various cancers; however, its cardiotoxic side effects restrict its therapeutic efficacy. Fisetin, a flavonoid phytoestrogen derived from a range of fruits and vegetables, has been reported to exert cardioprotective effects against DOX‐induced cardiotoxicity; however, the underlying mechanisms remain unclear. This study investigated fisetin's cardioprotective role and mechanism against DOX‐induced cardiotoxicity in H9c2 cardiomyoblasts and ovariectomized (OVX) rat models. MTT assay revealed that fisetin treatment noticeably rescued DOX‐induced cell death in a dose‐dependent manner. Moreover, western blotting and TUNEL‐DAPI staining showed that fisetin significantly attenuated DOX‐induced cardiotoxicity in vitro and in vivo by inhibiting the insulin‐like growth factor II receptor (IGF‐IIR) apoptotic pathway through estrogen receptor (ER)‐α/‐β activation. The echocardiography, biochemical assay, and H&E staining results demonstrated that fisetin reduced DOX‐induced cardiotoxicity by alleviating cardiac dysfunction, myocardial injury, oxidative stress, and histopathological damage. These findings imply that fisetin has a significant therapeutic potential against DOX‐induced cardiotoxicity." @default.
- W4367051857 created "2023-04-27" @default.
- W4367051857 creator A5006212022 @default.
- W4367051857 creator A5006883314 @default.
- W4367051857 creator A5016501260 @default.
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- W4367051857 creator A5025617602 @default.
- W4367051857 creator A5048538551 @default.
- W4367051857 creator A5079367503 @default.
- W4367051857 creator A5085006271 @default.
- W4367051857 creator A5087584598 @default.
- W4367051857 creator A5089695874 @default.
- W4367051857 date "2023-04-26" @default.
- W4367051857 modified "2023-10-17" @default.
- W4367051857 title "Fisetin attenuates doxorubicin‐induced cardiotoxicity by inhibiting the insulin‐like growth factor <scp>II</scp> receptor apoptotic pathway through estrogen receptor‐α/‐β activation" @default.
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