Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367051907> ?p ?o ?g. }
- W4367051907 endingPage "647" @default.
- W4367051907 startingPage "647" @default.
- W4367051907 abstract "Diabetic retinopathy (DR) primarily progresses into retinal degeneration caused by microvascular dysfunction. The pathophysiology of DR progression is still uncertain. This study investigates the function of beta-carotene (PBC) originating from palm oil mill effluent in the treatment of diabetes in mice. An intraperitoneal injection of streptozotocin (35 mg/kg) was used to induce diabetes, which was then accelerated by an intravitreal (i.vit.) injection of STZ (20 µL on day 7). PBC (50 and 100 mg/kg) and dexamethasone (DEX: 10 mg/kg) were also administered orally (p.o.) for 21 days. At various time intervals, the optomotor response (OMR) and visual-cue function test (VCFT) responses were evaluated. Biomarkers, such as reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARSs), and catalase activity were determined in retinal tissue samples. DR significantly lowers the spatial frequency threshold (SFT) and time spent in the target quadrant (TSTQ), increases the reaching time in the visual-cue platform (RVCP), lowers retinal GSH and catalase activity levels, and elevates TBARS levels. The treatments of PBC and DEX also ameliorate STZ-induced DR alterations. The potential ameliorative activity of PBC in DR is attributed to its anti-diabetic, anti-oxidative, and control of blood-retinal barrier layer properties." @default.
- W4367051907 created "2023-04-27" @default.
- W4367051907 creator A5009764179 @default.
- W4367051907 creator A5010802824 @default.
- W4367051907 creator A5052794537 @default.
- W4367051907 creator A5074474140 @default.
- W4367051907 creator A5078736850 @default.
- W4367051907 date "2023-04-26" @default.
- W4367051907 modified "2023-10-06" @default.
- W4367051907 title "Therapeutic Investigation of Palm Oil Mill Effluent-Derived Beta-Carotene in Streptozotocin-Induced Diabetic Retinopathy via the Regulation of Blood–Retina Barrier Functions" @default.
- W4367051907 cites W1537575246 @default.
- W4367051907 cites W1775749144 @default.
- W4367051907 cites W1865091000 @default.
- W4367051907 cites W1966588348 @default.
- W4367051907 cites W1968435325 @default.
- W4367051907 cites W1968525077 @default.
- W4367051907 cites W1980190852 @default.
- W4367051907 cites W1983310681 @default.
- W4367051907 cites W1985813071 @default.
- W4367051907 cites W1991309591 @default.
- W4367051907 cites W1991594237 @default.
- W4367051907 cites W1993100066 @default.
- W4367051907 cites W1999607568 @default.
- W4367051907 cites W2000937182 @default.
- W4367051907 cites W2004849647 @default.
- W4367051907 cites W2004937100 @default.
- W4367051907 cites W2006370393 @default.
- W4367051907 cites W2012669528 @default.
- W4367051907 cites W2034370648 @default.
- W4367051907 cites W2047351575 @default.
- W4367051907 cites W2060707314 @default.
- W4367051907 cites W2062246841 @default.
- W4367051907 cites W2062955140 @default.
- W4367051907 cites W2063285178 @default.
- W4367051907 cites W2079088704 @default.
- W4367051907 cites W2085808294 @default.
- W4367051907 cites W2086678739 @default.
- W4367051907 cites W2092846427 @default.
- W4367051907 cites W2094450831 @default.
- W4367051907 cites W2105869050 @default.
- W4367051907 cites W2116491662 @default.
- W4367051907 cites W2123307497 @default.
- W4367051907 cites W2145107163 @default.
- W4367051907 cites W2151143109 @default.
- W4367051907 cites W2510187337 @default.
- W4367051907 cites W2624988283 @default.
- W4367051907 cites W2625793869 @default.
- W4367051907 cites W2776801524 @default.
- W4367051907 cites W2781859544 @default.
- W4367051907 cites W2804460380 @default.
- W4367051907 cites W2806063230 @default.
- W4367051907 cites W2807823845 @default.
- W4367051907 cites W2885891351 @default.
- W4367051907 cites W2887768426 @default.
- W4367051907 cites W2912666599 @default.
- W4367051907 cites W2914059200 @default.
- W4367051907 cites W2934270146 @default.
- W4367051907 cites W2936260138 @default.
- W4367051907 cites W2944475952 @default.
- W4367051907 cites W2970939855 @default.
- W4367051907 cites W2977927188 @default.
- W4367051907 cites W2987300210 @default.
- W4367051907 cites W3002512709 @default.
- W4367051907 cites W3006862907 @default.
- W4367051907 cites W3036918539 @default.
- W4367051907 cites W3048414723 @default.
- W4367051907 cites W3083627720 @default.
- W4367051907 cites W3087984092 @default.
- W4367051907 cites W3093746978 @default.
- W4367051907 cites W3119618794 @default.
- W4367051907 cites W3133435951 @default.
- W4367051907 cites W3150040141 @default.
- W4367051907 cites W3157032742 @default.
- W4367051907 cites W3185112837 @default.
- W4367051907 cites W3189087951 @default.
- W4367051907 cites W4205499850 @default.
- W4367051907 cites W4210401989 @default.
- W4367051907 cites W4213126062 @default.
- W4367051907 cites W4220890602 @default.
- W4367051907 cites W4220949142 @default.
- W4367051907 cites W4221033034 @default.
- W4367051907 cites W4283396599 @default.
- W4367051907 cites W4283818688 @default.
- W4367051907 cites W4292120595 @default.
- W4367051907 cites W4307972935 @default.
- W4367051907 cites W4308782133 @default.
- W4367051907 cites W4317812667 @default.
- W4367051907 cites W4318672948 @default.
- W4367051907 cites W4324054826 @default.
- W4367051907 doi "https://doi.org/10.3390/ph16050647" @default.
- W4367051907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37242430" @default.
- W4367051907 hasPublicationYear "2023" @default.
- W4367051907 type Work @default.
- W4367051907 citedByCount "2" @default.
- W4367051907 countsByYear W43670519072023 @default.
- W4367051907 crossrefType "journal-article" @default.
- W4367051907 hasAuthorship W4367051907A5009764179 @default.
- W4367051907 hasAuthorship W4367051907A5010802824 @default.