FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367055936> ?p ?o ?g. }

• W4367055936 abstract "Abstract Viral inclusion bodies (IBs) commonly form during the replication of Ebola virus (EBOV) in infected cells, but their role in viral immune evasion has rarely been explored. Here, we found that interferon regulatory factor 3 (IRF3), but not TANK-binding kinase 1 (TBK-1) or IκB kinase epsilon (IKKε), was recruited and sequestered in viral IBs when the cells were infected by EBOV transcription- and replication-competent virus-like particles (trVLPs). NP/VP35-induced IBs formation was critical for IRF3 recruitment and sequestration, probably through interaction with STING. Consequently, the association of TBK1 and IRF3, which plays a vital role in type I interferon (IFN-I) induction, was blocked by EBOV trVLPs infection. Additionally, IRF3 phosphorylation and nuclear translocation induced by Sendai virus (SeV) or poly(I:C) stimulation were suppressed by EBOV trVLPs. Furthermore, downregulation of STING significantly attenuated VP35-induced IRF3 accumulation in IBs. Coexpression of the viral proteins by which IBs-like structures formed was much more potent in antagonizing IFN-I than expression of the IFN-I antagonist VP35 alone. These results suggested a novel immune evasion mechanism by which EBOV evades host innate immunity. Impact statement Ebola virus VP35 protein evades host antiviral immunity by interacting with STING to sequester IRF3 into inclusion bodies and inhibit type-I interferon production." @default.
• W4367055936 created "2023-04-27" @default.
• W4367055936 creator A5001366115 @default.
• W4367055936 creator A5027937292 @default.
• W4367055936 creator A5033245675 @default.
• W4367055936 creator A5039335131 @default.
• W4367055936 creator A5048345506 @default.
• W4367055936 creator A5056107013 @default.
• W4367055936 creator A5071396138 @default.
• W4367055936 creator A5072572836 @default.
• W4367055936 creator A5073070877 @default.
• W4367055936 creator A5077970115 @default.
• W4367055936 creator A5081093007 @default.
• W4367055936 creator A5082156574 @default.
• W4367055936 date "2023-04-26" @default.
• W4367055936 modified "2023-10-11" @default.
• W4367055936 title "Ebola Virus Sequesters IRF3 in Viral Inclusion Bodies to Evade Host Antiviral Immunity" @default.
• W4367055936 cites W1510487586 @default.
• W4367055936 cites W2002201547 @default.
• W4367055936 cites W2006635133 @default.
• W4367055936 cites W2017405972 @default.
• W4367055936 cites W2036436901 @default.
• W4367055936 cites W2040132891 @default.
• W4367055936 cites W2047365750 @default.
• W4367055936 cites W2052322746 @default.
• W4367055936 cites W2053804496 @default.
• W4367055936 cites W2057559854 @default.
• W4367055936 cites W2068551753 @default.
• W4367055936 cites W2069029008 @default.
• W4367055936 cites W2072510538 @default.
• W4367055936 cites W2076938612 @default.
• W4367055936 cites W2096009548 @default.
• W4367055936 cites W2099533608 @default.
• W4367055936 cites W2100827617 @default.
• W4367055936 cites W2107277218 @default.
• W4367055936 cites W2113449059 @default.
• W4367055936 cites W2122527653 @default.
• W4367055936 cites W2128293632 @default.
• W4367055936 cites W2131169185 @default.
• W4367055936 cites W2136920638 @default.
• W4367055936 cites W2144787399 @default.
• W4367055936 cites W2154187588 @default.
• W4367055936 cites W2160796054 @default.
• W4367055936 cites W2236504019 @default.
• W4367055936 cites W2238727653 @default.
• W4367055936 cites W2321213790 @default.
• W4367055936 cites W2586436691 @default.
• W4367055936 cites W2802974224 @default.
• W4367055936 cites W2906918014 @default.
• W4367055936 cites W2987719199 @default.
• W4367055936 cites W3118405239 @default.
• W4367055936 cites W3207688721 @default.
• W4367055936 cites W4220887281 @default.
• W4367055936 cites W4229439156 @default.
• W4367055936 doi "https://doi.org/10.1101/2023.04.20.537734" @default.
• W4367055936 hasPublicationYear "2023" @default.
• W4367055936 type Work @default.
• W4367055936 citedByCount "1" @default.
• W4367055936 countsByYear W43670559362023 @default.
• W4367055936 crossrefType "posted-content" @default.
• W4367055936 hasAuthorship W4367055936A5001366115 @default.
• W4367055936 hasAuthorship W4367055936A5027937292 @default.
• W4367055936 hasAuthorship W4367055936A5033245675 @default.
• W4367055936 hasAuthorship W4367055936A5039335131 @default.
• W4367055936 hasAuthorship W4367055936A5048345506 @default.
• W4367055936 hasAuthorship W4367055936A5056107013 @default.
• W4367055936 hasAuthorship W4367055936A5071396138 @default.
• W4367055936 hasAuthorship W4367055936A5072572836 @default.
• W4367055936 hasAuthorship W4367055936A5073070877 @default.
• W4367055936 hasAuthorship W4367055936A5077970115 @default.
• W4367055936 hasAuthorship W4367055936A5081093007 @default.
• W4367055936 hasAuthorship W4367055936A5082156574 @default.
• W4367055936 hasBestOaLocation W43670559361 @default.
• W4367055936 hasConcept C11960822 @default.
• W4367055936 hasConcept C136449434 @default.
• W4367055936 hasConcept C140704245 @default.
• W4367055936 hasConcept C156155473 @default.
• W4367055936 hasConcept C159047783 @default.
• W4367055936 hasConcept C203014093 @default.
• W4367055936 hasConcept C2522874641 @default.
• W4367055936 hasConcept C2776178377 @default.
• W4367055936 hasConcept C2777469322 @default.
• W4367055936 hasConcept C2779341262 @default.
• W4367055936 hasConcept C2780209191 @default.
• W4367055936 hasConcept C86803240 @default.
• W4367055936 hasConcept C8891405 @default.
• W4367055936 hasConcept C90934575 @default.
• W4367055936 hasConcept C9173399 @default.
• W4367055936 hasConcept C95444343 @default.
• W4367055936 hasConcept C97029542 @default.
• W4367055936 hasConceptScore W4367055936C11960822 @default.
• W4367055936 hasConceptScore W4367055936C136449434 @default.
• W4367055936 hasConceptScore W4367055936C140704245 @default.
• W4367055936 hasConceptScore W4367055936C156155473 @default.
• W4367055936 hasConceptScore W4367055936C159047783 @default.
• W4367055936 hasConceptScore W4367055936C203014093 @default.
• W4367055936 hasConceptScore W4367055936C2522874641 @default.
• W4367055936 hasConceptScore W4367055936C2776178377 @default.
• W4367055936 hasConceptScore W4367055936C2777469322 @default.
• W4367055936 hasConceptScore W4367055936C2779341262 @default.

• next