FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367059216> ?p ?o ?g. }

• W4367059216 abstract "Abstract Background Metrnl is a new kind of adipokine, which is also known as meteorin-like because it is homologous to the neurotrophic factor meteorin (Metrn). Although the expression and function of Metrnl, including neurotrophic, immunomodulatory, and insulin resistance functions in different tissues, have been extensively studied, research on its role in sepsis has remained largely limited. Methods The present work analyzed the levels of Metrnl and cytokines in the circulation, such as tumor necrosis factor (TNF-α), interleukin (IL-1)β, IL-6, IL-8, together with IL-10 among septic adult patients. Clinical information was obtained from such patients, including sofa score, procalcitonin(PCT)count, and C-reactive count (CRP) at the time of entering the intensive care unit (ICU). We constructed a sepsis model in Metrnl-deficient or normal wild-type mice using cecal ligation and perforation to study its functions in bacterial burden, survival, cytokine/chemokine generation, peritoneal lavage fluid neutrophils, macrophage and lymphocyte recruitment, and Treg/Th17 immune cell balance after CLP-induced sepsis. Results The expression of Metrnl was remarkably elevated in the early phase of sepsis clinically. Its serum content in patients dying of sepsis slightly decreased relative to that in survivors. Furthermore, the concentration of Metrnl in septic cases when entering the ICU independently predicted the 28-day mortality. For septic patients who had low serum Metrnl content (≤ 359.40 pg/mL), the death risk increased by 2.3 folds relative to those who had a high serum content. It is reported that Metrnl is probably insufficient among patients dying of sepsis. Additionally, the content of Metrnl in the serum of septic patients when entering the ICU is markedly and negatively related to the levels of TNF-α, IL-1β, IL-6, IL-8, IL-17, PCT, and Sofa score. Collectively, Metrnl could be a potential therapeutic target for sepsis. A low-lethality non-severe sepsis (NSS) model was constructed, which suggested that Metrnl insufficiency elevated the death rate and reduced bacterial clearance during sepsis. For Metrnl-deficient mice, impaired sepsis immunity defense might be related to decreased macrophage recruitment and Treg/Th17 lymphocyte imbalance. Recombinant Metrnl administered to Metrnl-deficient mice abolished the immunity defense impairment following NSS while protecting the high-lethality severe sepsis (SS) model in wild-type (WT) mice. In addition, Metrnl-induced sepsis prevention was intricately associated with the increased recruitment of peritoneal macrophages and modulation of the Treg/TH17 immune cell balance. Furthermore, CCL3 exposure in Metrnl-deficient mice reduced peritoneal bacterial loads while improving survival during sepsis partially by promoting the recruitment of peritoneal macrophages. Furthermore, Metrnl regulated the polarization of M1 macrophages through the ROS signaling pathway and promoted macrophage phagocytosis, thereby killing Escherichia coli . Conclusions The present proof-of-concept work suggests that Metrnl-mediated recruitment of macrophages significantly affects sepsis defense in the host and modulates the Treg/Th17 immune cell balance. Findings in this work shed more light on the development of host-directed treatments that can be used to manipulate host immunity to treat sepsis." @default.
• W4367059216 created "2023-04-27" @default.
• W4367059216 creator A5008171524 @default.
• W4367059216 creator A5021637377 @default.
• W4367059216 creator A5051020682 @default.
• W4367059216 creator A5052729067 @default.
• W4367059216 creator A5058395349 @default.
• W4367059216 creator A5065418722 @default.
• W4367059216 creator A5077865669 @default.
• W4367059216 creator A5083265838 @default.
• W4367059216 date "2023-04-26" @default.
• W4367059216 modified "2023-09-30" @default.
• W4367059216 title "Protective Role of Metrnl in Host Immunity Defense during Sepsis by Promoting Macrophage Recruitment and Modulating Treg/Th17 Immune Cell Balance" @default.
• W4367059216 cites W1550733776 @default.
• W4367059216 cites W1714100872 @default.
• W4367059216 cites W1998427452 @default.
• W4367059216 cites W2023945291 @default.
• W4367059216 cites W2026170842 @default.
• W4367059216 cites W2121191508 @default.
• W4367059216 cites W2148101159 @default.
• W4367059216 cites W2161340995 @default.
• W4367059216 cites W2195240341 @default.
• W4367059216 cites W2223946157 @default.
• W4367059216 cites W2280404143 @default.
• W4367059216 cites W2317947758 @default.
• W4367059216 cites W2513799135 @default.
• W4367059216 cites W2540365220 @default.
• W4367059216 cites W2608823051 @default.
• W4367059216 cites W2734654353 @default.
• W4367059216 cites W2739792624 @default.
• W4367059216 cites W2763449827 @default.
• W4367059216 cites W2801386335 @default.
• W4367059216 cites W2804155996 @default.
• W4367059216 cites W2808829764 @default.
• W4367059216 cites W2890101779 @default.
• W4367059216 cites W2890380917 @default.
• W4367059216 cites W2894456061 @default.
• W4367059216 cites W2900362176 @default.
• W4367059216 cites W2901130621 @default.
• W4367059216 cites W2901434239 @default.
• W4367059216 cites W2912636552 @default.
• W4367059216 cites W2929166201 @default.
• W4367059216 cites W2939772398 @default.
• W4367059216 cites W2945777288 @default.
• W4367059216 cites W2966577796 @default.
• W4367059216 cites W2979807405 @default.
• W4367059216 cites W2999517511 @default.
• W4367059216 cites W3005937827 @default.
• W4367059216 cites W3024841775 @default.
• W4367059216 cites W3090704294 @default.
• W4367059216 cites W3095088683 @default.
• W4367059216 cites W3096818982 @default.
• W4367059216 cites W3170294126 @default.
• W4367059216 cites W3185254581 @default.
• W4367059216 cites W3187418235 @default.
• W4367059216 cites W3201959609 @default.
• W4367059216 cites W4200070125 @default.
• W4367059216 cites W4206531965 @default.
• W4367059216 cites W4221015328 @default.
• W4367059216 cites W4221120087 @default.
• W4367059216 cites W4280533270 @default.
• W4367059216 cites W4285090764 @default.
• W4367059216 cites W4312959532 @default.
• W4367059216 cites W748993927 @default.
• W4367059216 doi "https://doi.org/10.21203/rs.3.rs-2851202/v1" @default.
• W4367059216 hasPublicationYear "2023" @default.
• W4367059216 type Work @default.
• W4367059216 citedByCount "0" @default.
• W4367059216 crossrefType "posted-content" @default.
• W4367059216 hasAuthorship W4367059216A5008171524 @default.
• W4367059216 hasAuthorship W4367059216A5021637377 @default.
• W4367059216 hasAuthorship W4367059216A5051020682 @default.
• W4367059216 hasAuthorship W4367059216A5052729067 @default.
• W4367059216 hasAuthorship W4367059216A5058395349 @default.
• W4367059216 hasAuthorship W4367059216A5065418722 @default.
• W4367059216 hasAuthorship W4367059216A5077865669 @default.
• W4367059216 hasAuthorship W4367059216A5083265838 @default.
• W4367059216 hasBestOaLocation W43670592161 @default.
• W4367059216 hasConcept C10936531 @default.
• W4367059216 hasConcept C126322002 @default.
• W4367059216 hasConcept C13373296 @default.
• W4367059216 hasConcept C17991360 @default.
• W4367059216 hasConcept C203014093 @default.
• W4367059216 hasConcept C2777465075 @default.
• W4367059216 hasConcept C2778384902 @default.
• W4367059216 hasConcept C71924100 @default.
• W4367059216 hasConcept C86803240 @default.
• W4367059216 hasConcept C8891405 @default.
• W4367059216 hasConceptScore W4367059216C10936531 @default.
• W4367059216 hasConceptScore W4367059216C126322002 @default.
• W4367059216 hasConceptScore W4367059216C13373296 @default.
• W4367059216 hasConceptScore W4367059216C17991360 @default.
• W4367059216 hasConceptScore W4367059216C203014093 @default.
• W4367059216 hasConceptScore W4367059216C2777465075 @default.
• W4367059216 hasConceptScore W4367059216C2778384902 @default.
• W4367059216 hasConceptScore W4367059216C71924100 @default.
• W4367059216 hasConceptScore W4367059216C86803240 @default.
• W4367059216 hasConceptScore W4367059216C8891405 @default.
• W4367059216 hasLocation W43670592161 @default.
• W4367059216 hasOpenAccess W4367059216 @default.

• next