Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367059319> ?p ?o ?g. }
- W4367059319 endingPage "e202201876" @default.
- W4367059319 startingPage "e202201876" @default.
- W4367059319 abstract "Although ubiquitin is found only in eukaryotes, several pathogenic bacteria and viruses possess proteins that hinder the host ubiquitin system. Legionella, a gram-negative intracellular bacterium, possesses an ovarian tumor (OTU) family of deubiquitinases (Lot DUBs). Herein, we describe the molecular characteristics of Lot DUBs. We elucidated the structure of the LotA OTU1 domain and revealed that entire Lot DUBs possess a characteristic extended helical lobe that is not found in other OTU-DUBs. The structural topology of an extended helical lobe is the same throughout the Lot family, and it provides an S1' ubiquitin-binding site. Moreover, the catalytic triads of Lot DUBs resemble those of the A20-type OTU-DUBs. Furthermore, we revealed a unique mechanism by which LotA OTU domains cooperate together to distinguish the length of the chain and preferentially cleave longer K48-linked polyubiquitin chains. The LotA OTU1 domain itself cleaves K6-linked ubiquitin chains, whereas it is also essential for assisting the cleavage of longer K48-linked polyubiquitin chains by the OTU2 domain. Thus, this study provides novel insights into the structure and mechanism of action of Lot DUBs." @default.
- W4367059319 created "2023-04-27" @default.
- W4367059319 creator A5038527469 @default.
- W4367059319 creator A5066046810 @default.
- W4367059319 creator A5069141743 @default.
- W4367059319 creator A5076278973 @default.
- W4367059319 creator A5079762603 @default.
- W4367059319 creator A5080047287 @default.
- W4367059319 creator A5085715323 @default.
- W4367059319 date "2023-04-26" @default.
- W4367059319 modified "2023-09-28" @default.
- W4367059319 title "Structural insights into ubiquitin chain cleavage by<i>Legionella</i>ovarian tumor deubiquitinases" @default.
- W4367059319 cites W1756259937 @default.
- W4367059319 cites W1971190621 @default.
- W4367059319 cites W1972002218 @default.
- W4367059319 cites W1976041483 @default.
- W4367059319 cites W1985169370 @default.
- W4367059319 cites W1999290683 @default.
- W4367059319 cites W2003123340 @default.
- W4367059319 cites W2011711371 @default.
- W4367059319 cites W2029526066 @default.
- W4367059319 cites W2032997281 @default.
- W4367059319 cites W2033627048 @default.
- W4367059319 cites W2037239543 @default.
- W4367059319 cites W2039753711 @default.
- W4367059319 cites W2046791391 @default.
- W4367059319 cites W2067340670 @default.
- W4367059319 cites W2072313716 @default.
- W4367059319 cites W2074704372 @default.
- W4367059319 cites W2080554514 @default.
- W4367059319 cites W2095803950 @default.
- W4367059319 cites W2097278543 @default.
- W4367059319 cites W2099598643 @default.
- W4367059319 cites W2101572186 @default.
- W4367059319 cites W2104234755 @default.
- W4367059319 cites W2110960544 @default.
- W4367059319 cites W2118225942 @default.
- W4367059319 cites W2121983892 @default.
- W4367059319 cites W2124026197 @default.
- W4367059319 cites W2125254321 @default.
- W4367059319 cites W2125596943 @default.
- W4367059319 cites W2133486297 @default.
- W4367059319 cites W2144795375 @default.
- W4367059319 cites W2145301886 @default.
- W4367059319 cites W2147917253 @default.
- W4367059319 cites W2152630268 @default.
- W4367059319 cites W2154197653 @default.
- W4367059319 cites W2158006209 @default.
- W4367059319 cites W2163341755 @default.
- W4367059319 cites W2318667448 @default.
- W4367059319 cites W2328753773 @default.
- W4367059319 cites W2342445885 @default.
- W4367059319 cites W2398731353 @default.
- W4367059319 cites W2409179396 @default.
- W4367059319 cites W2466579264 @default.
- W4367059319 cites W2530082208 @default.
- W4367059319 cites W2559315320 @default.
- W4367059319 cites W2576744143 @default.
- W4367059319 cites W2587625522 @default.
- W4367059319 cites W2611510717 @default.
- W4367059319 cites W2613065881 @default.
- W4367059319 cites W2734415948 @default.
- W4367059319 cites W2757317176 @default.
- W4367059319 cites W2768830479 @default.
- W4367059319 cites W2789777795 @default.
- W4367059319 cites W2790295680 @default.
- W4367059319 cites W2792227597 @default.
- W4367059319 cites W2793122718 @default.
- W4367059319 cites W2793198937 @default.
- W4367059319 cites W2803828311 @default.
- W4367059319 cites W2898232581 @default.
- W4367059319 cites W2899714098 @default.
- W4367059319 cites W2914591999 @default.
- W4367059319 cites W2944979483 @default.
- W4367059319 cites W2945860513 @default.
- W4367059319 cites W2953320394 @default.
- W4367059319 cites W2963986130 @default.
- W4367059319 cites W2983004433 @default.
- W4367059319 cites W3000089338 @default.
- W4367059319 cites W3035797211 @default.
- W4367059319 cites W3081431274 @default.
- W4367059319 cites W3088279627 @default.
- W4367059319 cites W3093295276 @default.
- W4367059319 cites W3095303497 @default.
- W4367059319 cites W3099444316 @default.
- W4367059319 cites W3119486354 @default.
- W4367059319 cites W3177086285 @default.
- W4367059319 cites W3177828909 @default.
- W4367059319 cites W3199005987 @default.
- W4367059319 cites W4205715916 @default.
- W4367059319 cites W4210757594 @default.
- W4367059319 cites W4210840673 @default.
- W4367059319 cites W4213071665 @default.
- W4367059319 cites W4255701985 @default.
- W4367059319 cites W4280583631 @default.
- W4367059319 cites W4281790889 @default.
- W4367059319 cites W4294970362 @default.
- W4367059319 cites W4307216811 @default.